呼吸道疾病

呼吸道疾病是涉及從鼻腔到肺部的呼吸系統(tǒng)的多種疾病群。常見的類型包括感冒和流感（由病毒引起）、支氣管炎（支氣管的炎癥）、哮喘（慢性炎癥性肺病）、慢性阻塞性肺?。–OPD，包括慢性支氣管炎和肺氣腫）、肺炎（肺部感染）、肺結(jié)核（由結(jié)核桿菌引起的傳染性疾病）以及肺癌（肺部惡性腫瘤）。這些疾病可能由病毒、細(xì)菌、過敏原、污染物、吸煙和其他環(huán)境因素引起。

目前，針對(duì)呼吸道疾病的藥物開發(fā)主要集中在以下幾個(gè)方面：

炎癥介質(zhì)：即抗炎藥物，目的是減少哮喘和COPD等炎癥性肺病的癥狀。同時(shí)，針對(duì)特定炎癥介質(zhì)的生物制劑正在開發(fā)，如抗IL-5和抗IL-13，用于治療嚴(yán)重的哮喘。
抗菌藥物：針對(duì)耐藥性細(xì)菌的新型抗菌藥物對(duì)于治療肺炎等呼吸道感染至關(guān)重要。
免疫檢查點(diǎn)：如PD-1/PD-L1抑制劑等免疫療法，用于治療肺癌。
基因治療：針對(duì)遺傳性呼吸系統(tǒng)疾病，如囊性纖維化的基因治療正在研究中。
腫瘤標(biāo)志物：靶向治療，如EGFR抑制劑，正在非小細(xì)胞肺癌的治療中發(fā)揮作用。
疫苗：流感疫苗和肺炎球菌疫苗等針對(duì)呼吸道疾病的疫苗不斷更新以適應(yīng)病原體的變異。

呼吸道疾病藥物靶點(diǎn)

呼吸道疾病靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

EGFR
CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

ACE2
CSB-MP866317HU

SARS-CoV-2 Spike protein RBD his/sumostar tag (CSB-YP3324GMY1) captured on COOH chip can bind Human ACE2 protein Fc tag (CSB-MP866317HU) with an affinity constant of 100 nM as detected by LSPR Assay.

TACSTD2(TROP2)
CSB-MP023072HU1

Measured in cell activity assay using U937 cells, the EC₅₀ for this effect is 190.2-298.6 ng/ml.

CTLA4
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

IL4R
CSB-MP011661HU2-B

Measured by its binding ability in a functional ELISA. Immobilized Human IL4 (CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R，the EC₅₀ is 12.68-14.23 ng/mL.

ERBB2
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	來源	蛋白標(biāo)簽
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial (Active)	CSB-AP005671HU	ACE2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial, Biotinylated (Active)	CSB-MP866317HU-B	ACE2	Mammalian cell	C-terminal mFc-Avi-tagged
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial (Active)	CSB-MP866317HU	ACE2	Mammalian cell	C-terminal hFc-tagged
Recombinant Macaca fascicularis Angiotensin-converting enzyme (ACE2), partial (Active)	CSB-MP3414MOV	ACE2	Mammalian cell	C-terminal hFc-tagged
Recombinant Paguma larvata Angiotensin-converting enzyme 2 (ACE2), partial (Active)	CSB-MP684964PAL	ACE2	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Basigin (BSG), partial (Active)	CSB-MP002831HU1	BSG	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active)	CSB-MP733578HU	CD276	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active)	CSB-AP005161HU	CD86	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active)	CSB-MP005165HU	CEACAM5	Mammalian cell	C-terminal?10xHis-tagged
Recombinant Human Claudin-6 (CLDN6)-VLPs (Active)	CSB-MP005508HU(A4)	CLDN6	Mammalian cell	C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active)	CSB-MP005508HU(A4)f4	CLDN6	Mammalian cell	C-terminal GFP-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003581HU	CSF2	E.coli	Tag-Free
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003601HU	CSF2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active)	CSB-AP003651MO	Csf2	Mammalian cell	C-terminal 6xHis-tagged

● 穩(wěn)定細(xì)胞株

HEK293T/Human CLDN6 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

HEK293F/Human DLL3 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293 cells (green line) and transfected Human DLL3 HEK293 stable cells (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.

● 重組抗體

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	反應(yīng)種屬	應(yīng)用范圍
ALB Recombinant Monoclonal Antibody	CSB-RA264109A0HU	ALB	Human	ELISA, FC
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD27 Recombinant Monoclonal Antibody	CSB-RA953976A0HU	CD27	Human	ELISA, WB
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD4 Recombinant Monoclonal Antibody	CSB-RA004935A0HU	CD4	Human	ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CD86 Recombinant Monoclonal Antibody	CSB-RA004965A0HU	CD86	Human	ELISA, WB
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA3HU	CEACAM5	Human	ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA1HU	CEACAM5	Human	ELISA
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
DLL3 Recombinant Monoclonal Antibody	CSB-RA882142A1HU	DLL3	Human	ELISA, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC
ELANE Recombinant Monoclonal Antibody	CSB-RA200985A0HU	ELANE	Human	ELISA, IHC, FC

● ELISA試劑盒

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	檢測范圍	靈敏度
Rat Angiotensin converting enzyme 2, ACE2 ELISA Kit	CSB-E14308r	ACE2	0.02 ng/ml - 20 ng/ml	0.02 ng/ml
Human Angiotensin converting enzyme 2, ACE2 ELISA Kit	CSB-E04489h	ACE2	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Mouse Angiotensin converting enzyme 2(ACE2)ELISA Kit	CSB-E17204m	ACE2	6.25 pg/mL-400 pg/mL	1.56 pg/mL
Bovine Albumin(Alb) ELISA kit	CSB-E08664b	ALB	0.313 μg/mL-80 μg/mL	0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit	CSB-E13878m	ALB	0.781 μg/mL-200 μg/mL	0.110 μg/mL
Dog Albumin(Alb) ELISA Kit	CSB-E15757c	ALB	0.273 μg/mL-35 μg/mL	0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit	CSB-E15839Sh	ALB	350 μg/mL-21.88 μg/mL	5.5 μg/mL
Horse Albumin(Alb) ELISA Kit	CSB-E16205Hs	ALB	1.25 μg/mL-80 μg/mL	1.247 μg/mL
Pig Albumin (Alb) ELISA Kit	CSB-E16207p	ALB	0.03 μg/mL-7000 μg/mL	0.03 μg/mL
Goat Albumin (Alb)ELISA Kit	CSB-E15758G	ALB	0.17 μg/mL-350 μg/mL	0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit	CSB-E15765Gp	ALB	0.156 μg/mL-10 μg/mL	0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit	CSB-E16204Rb	ALB	0.273 μg/mL-70 μg/mL	0.117 μg/mL
Bovine Angiopoietin-1(ANGPT1) ELISA kit	CSB-EL001706BO	ANGPT1	12.5 ng/mL-800 ng/mL	1.384 ng/mL
Human Angiopoietin-1(ANGPT1) ELISA kit	CSB-EL001706HU	ANGPT1	1.25 ng/mL-80 ng/mL	0.091 ng/mL
Mouse Angiopoietin 1,ANG-1 ELISA Kit	CSB-E07302m	ANGPT1	1.25 ng/mL-80 ng/mL	0.312 ng/mL
Rat Angiopoietin 1,ANG-1 ELISA Kit	CSB-E07303r	ANGPT1	6.25 ng/mL-400 ng/mL	1.56 ng/mL
Pig Angiopoietin 1,ANG-1 ELISA Kit	CSB-E08457p	ANGPT1	6 ng/mL-200 ng/mL	6 ng/mL
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit	CSB-EL002476HU	AXL	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit	CSB-EL002476MO	AXL	31.25 pg/ml-2000 pg/ml	7.81 pg/ml
Human Cluster of differentiation 147,CD147 Elisa Kit	CSB-E12994h	BSG	12.5 pg/mL-800 pg/mL	3.12 pg/mL