CSF1R
Csf1r，全稱是集落刺激因子1受體（Colony-Stimulating Factor 1 Receptor），常見別名包括M-CSFR、CSF-1R、CD115和FMS。該蛋白主要存在于單核吞噬細胞，特別是巨噬細胞和單核細胞中，參與多種生物過程。Csf1r蛋白能夠響應IL34和CSF1的誘導，促進促炎趨化因子的釋放，對先天免疫和炎癥起到重要作用。此外，Csf1r蛋白還在調節破骨細胞的增殖和分化、骨吸收、正常骨骼和牙齒發育方面發揮著關鍵作用，并且對男性和女性的正常生育能力以及懷孕期間乳腺中乳管和腺泡結構的發育至關重要。
近年來，Csf1r蛋白已成為藥物研發的重要靶點。由于高水平的CSF1和Csf1r蛋白在多種癌癥中被報道，且與不良預后相關，因此針對Csf1r蛋白的小分子抑制劑和抗體正在臨床開發中，顯示出抗腫瘤活性。例如，Incyte和Syndax Pharmaceuticals公司開發的Axatilimab，以及羅氏制藥和Celleron Therapeutics共同開發的Emactuzumab，都是針對Csf1r蛋白的抑制劑，分別用于治療慢性移植物抗宿主病和腱鞘巨細胞瘤等疾病。這些藥物在臨床試驗中展現出良好的療效，為Csf1r蛋白靶點藥物的研發提供了新的希望。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Mouse Csf1(CSB-MP006043MO) at 2 μg/ml can bind Mouse Csf1r. The EC50 is 3.226-4.264 ng/mL.
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
①Measured by its binding ability in a functional ELISA. Immobilized Human CSF1R at 2 μg/ml can bind Anti-CSF1R recombinant antibody (CSB-RA006044MA1HU). The EC50 is 1.800-2.218 ng/mL.
Activity
②Measured by its binding ability in a functional ELISA. Immobilized Human CSF1R at 2 μg/ml can bind Human CSF1 (CSB-MP006043HU1). The EC50 is 22.53-25.44 ng/mL.
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數據
Western Blot analysis of COLO cells using c-Fms Polyclonal Antibody
Western Blot analysis of HEPG2 using c-Fms Polyclonal Antibody
Human Macrophage Colony-Stimulating Factor Receptor,M-CSFR ELISA Kit (CSB-E10012h)
驗證數據
貨號：CSB-E10012h
規格：96T/48T
靈敏度：0.039 ng/mL
檢測范圍：0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CSF1R Antibodies
CSF1R for Felis silvestris catus
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006044LA01CA | CSF1R Antibody | Felis silvestris catus | ELISA |
CSF1R for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA084386 | Phospho-CSF1R (Tyr809) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA924224 | Phospho-CSF1R (Tyr561) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA202220 | Phospho-CSF1R (Tyr708) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA696464 | CSF1R (Ab-809) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA152912 | Phospho-CSF1R (Tyr699) Antibody | Human | ELISA,WB |
| CSB-PA940519 | Phospho-CSF1R (Tyr809) Antibody | Human | ELISA,IHC |
| CSB-PA001596 | CSF1R Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA001597 | CSF1R Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA007328 | Phospho-CSF1R (Y809) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007329 | Phospho-CSF1R (Y699) Antibody | Human | WB, ELISA |
| CSB-PA007330 | Phospho-CSF1R (Y708) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007331 | Phospho-CSF1R (Y723) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007332 | Phospho-CSF1R (Y561) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007333 | Phospho-CSF1R (Y809) Antibody | Human | IHC, ELISA |
| CSB-PA007334 | CSF1R Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA007335 | CSF1R Antibody | Human | WB, ELISA |
| CSB-PA007337 | CSF1R Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA300271 | CSF1R Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA678661 | CSF1R Antibody | Human,Mouse,Rat | ELISA,WB |
CSF1R Proteins
CSF1R Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006044CA CSB-BP006044CA CSB-MP006044CA CSB-EP006044CA-B |
Recombinant Cat Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006044CA | Recombinant Cat Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | E.coli |
CSF1R Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006044HU CSB-EP006044HU CSB-BP006044HU CSB-EP006044HU-B |
Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP006044HU | Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Mammalian cell |
| CSB-MP006044HUi10 | Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Mammalian cell |
| CSB-MP006044HUd7 | Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial (Active) | Mammalian cell |
CSF1R Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006044MO CSB-EP006044MO CSB-BP006044MO CSB-EP006044MO-B |
Recombinant Mouse Macrophage colony-stimulating factor 1 receptor (Csf1r), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSF1R Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP888246DIL CSB-EP888246DIL CSB-BP888246DIL CSB-MP888246DIL CSB-EP888246DIL-B |
Recombinant Danio rerio Macrophage colony-stimulating factor 1 receptor (csf1r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF1R ELISA Kit
CSF1R ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E10012h | Human Macrophage Colony-Stimulating Factor Receptor,M-CSFR ELISA Kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
CSF1R ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006044RA | Rat Macrophage colony-stimulating factor 1 receptor(CSF1R) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
