MUC1
MUC1，即黏蛋白1，別名MAM6、EMA等。它是一種高度糖基化的I型跨膜蛋白，由MUC1基因編碼，該基因位于染色體1q22上，通過(guò)選擇性剪接可產(chǎn)生多種亞型。MUC1蛋白主要包括細(xì)胞外區(qū)域、跨膜區(qū)和細(xì)胞質(zhì)區(qū)，其中細(xì)胞外區(qū)域包含大量可發(fā)生O-糖基化的絲氨酸和蘇氨酸殘基，這些糖基化對(duì)于MUC1的生物學(xué)功能至關(guān)重要 。MUC1在生物學(xué)上的意義非常廣泛，它在正常上皮細(xì)胞中作為保護(hù)性屏障，防止外界環(huán)境及微生物的侵害。然而，在腫瘤細(xì)胞中，MUC1的表達(dá)量通常會(huì)增高，并且其結(jié)構(gòu)和糖基化水平也會(huì)發(fā)生改變。這些改變可能導(dǎo)致新的抗原表位的暴露，為腫瘤的診斷和治療提供了潛在的靶點(diǎn)。MUC1還參與了多種信號(hào)通路的調(diào)控，包括MAPK、PI3K/Akt和Wnt路徑，這些信號(hào)通路在腫瘤細(xì)胞代謝、細(xì)胞凋亡、上皮間質(zhì)轉(zhuǎn)化和遠(yuǎn)處轉(zhuǎn)移中發(fā)揮重要作用 。MUC1的異常表達(dá)與腫瘤的侵襲性和轉(zhuǎn)移能力密切相關(guān)，使其成為腫瘤治療和診斷中的一個(gè)重要靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Mucin-1 (MUC1) (CSB-EP015215HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MUC1 Antibody (CSB-PA11319A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA11319A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA11319A0Rb at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA11319A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
MUC1 Antibodies
MUC1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA11319A0Rb | MUC1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA11319C0Rb | MUC1 Antibody, FITC conjugated | Human | |
| CSB-PA015215GA01HU | MUC1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA11319B0Rb | MUC1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA11319D0Rb | MUC1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA150023 | Phospho-MUC1 (Tyr1229) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA003334 | MUC1 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA006277 | MUC1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA010263 | Phospho-MUC1 (Y1229) Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA010272 | Phospho-MUC1 (Y1243) Antibody | Human,Mouse | IHC, ELISA |
| CSB-PA010274 | Phospho-MUC1 (S1227) Antibody | Human | IHC, ELISA |
| CSB-PA010276 | MUC1 Antibody | Human | IHC, ELISA |
| CSB-PA010277 | MUC1 Antibody | Human | IHC, IF, ELISA |
| CSB-PA010279 | MUC1 Antibody | Human,Mouse | IHC, IF, ELISA |
| CSB-PA141385 | MUC1 Antibody | Human | ELISA,IHC |
| CSB-PA114224 | MUC1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA692815 | MUC1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA583379 | MUC1 Antibody | Human,Mouse | ELISA,IHC |
MUC1 Proteins
MUC1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-BP312543MO CSB-MP312543MO CSB-EP312543MO-B |
Recombinant Mouse Mucin-1 (Muc1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MUC1 Proteins for Hylobates lar (Common gibbon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP645848HXW CSB-EP645848HXW CSB-BP645848HXW CSB-MP645848HXW CSB-EP645848HXW-B |
Recombinant Hylobates lar Mucin-1 (MUC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MUC1 Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP726652MRG CSB-EP726652MRG CSB-BP726652MRG CSB-MP726652MRG CSB-EP726652MRG-B |
Recombinant Mesocricetus auratus Mucin-1 (MUC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MUC1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP848794BO CSB-EP848794BO CSB-BP848794BO CSB-MP848794BO CSB-EP848794BO-B |
Recombinant Bovine Mucin-1 (MUC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MUC1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-MP015215HU3-B | Recombinant Human Mucin-1(MUC1),partial,Biotinylated | Mammalian cell |
| CSB-MP015215HU2 | Recombinant Human Mucin-1 (MUC1), partial | Mammalian cell |
MUC1 ELISA Kit
MUC1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04772h | Human mammary carcinoma marker CA15-3 (CA15-3) ELISA kit | serum | 3.8 U/mL |
