血液和淋巴疾病

非腫瘤性血液和淋巴疾病包括一系列影響血液成分和淋巴系統功能的狀況，如貧血、凝血障礙、血小板異常、骨髓增生異常綜合征等。這些疾病的治療方法多樣，包括藥物治療、輸血、骨髓移植等。近年來，針對這些非腫瘤性血液和淋巴疾病的藥物研發也取得了顯著進展。

貧血：貧血是血液中紅細胞數量或血紅蛋白含量低于正常水平的疾病。治療貧血的新藥物研發主要集中在刺激紅細胞生成的藥物，如紅細胞生成素（erythropoiesis-stimulating agents, ESAs）。ESAs通過模擬內源性紅細胞生成素的作用，促進紅細胞的產生，用于治療慢性腎臟病引起的貧血。
凝血障礙：凝血障礙是指血液凝固過程受到影響的疾病，如血友病。在這一領域，新藥物的研發主要集中在替代療法和基因療法。例如，重組凝血因子的開發為血友病患者提供了有效的替代治療。此外，基因療法的研究也在不斷進展，旨在通過修復或替換有缺陷的基因來治療凝血障礙。
血小板異常：血小板異常疾病包括血小板數量減少或功能異常，如免疫性血小板減少性紫癜（ITP）。治療ITP的新藥物，如血小板生成素受體激動劑（thrombopoietin receptor agonists, TPO-RAs），通過模擬血小板生成素的作用，增加血小板的產生，從而減少出血風險。
骨髓增生異常綜合征：骨髓增生異常綜合征是一組骨髓細胞異常增生的疾病，可能導致貧血、出血傾向和感染風險增加。目前，治療這些疾病的新藥物研發包括免疫調節劑和靶向治療藥物。例如，免疫抑制劑如環孢素和他克莫司可用于治療某些類型的骨髓增生異常綜合征。

血液和淋巴疾病藥物靶點

血液和淋巴疾病靶點相關產品推薦

● 靶點蛋白

MS4A1 (CD20)
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL

TNFRSF17
CSB-MP023974HU1

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

CD22
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC₅₀ of human CD22 protein is 4.034-4.800 ng/ml.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CD47
CSB-MP004940HU

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CD33
CSB-MP004925HU

Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC₅₀ of human CD33 protein is 4.289- 5.312 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

TNFRSF8
CSB-MP023983HU1

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC₅₀ is 14.96-20.25 ng/ml

產品名稱	貨號	靶點	來源	蛋白標簽
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	CSB-AP005061HU	CD19	Mammalian cell	C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active)	CSB-MP004900HU	CD22	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active)	CSB-MP004925HU	CD33	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-AP005191HU	CD40LG	E.coli	Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-MP004937HU3	CD40LG	Mammalian cell	N-terminal hFc-Flag-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human T-cell antigen CD7 (CD7), partial (Active)	CSB-MP004953HU	CD7	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active)	CSB-MP004954HU1	CD70	Mammalian cell	N-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003581HU	CSF2	E.coli	Tag-Free
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003601HU	CSF2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active)	CSB-AP003651MO	Csf2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active)	CSB-AP003661MO	Csf2	E.coli	Tag-Free
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active)	CSB-AP003591HU	CSF2RA	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged

● 穩定細胞株

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

ALB Recombinant Monoclonal Antibody
CSB-RA264109A0HU

Overlay Peak curve showing HepG2 cells stained with CSB-RA264109A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD3E Recombinant Monoclonal Antibody
CSB-RA004931MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.

TOP1 Recombinant Monoclonal Antibody
CSB-RA792129A0HU

Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.

產品名稱	貨號	靶點	反應種屬	應用范圍
ALB Recombinant Monoclonal Antibody	CSB-RA264109A0HU	ALB	Human	ELISA, FC
C3 Recombinant Monoclonal Antibody	CSB-RA303909A0HU	C3	Human	ELISA, WB, IHC, FC
C3 Recombinant Monoclonal Antibody	CSB-RA699863A0HU	C3	Human	ELISA, IHC
C5 Recombinant Monoclonal Antibody	CSB-RA003995MA1HU	C5	Human	ELISA, FC
CD19 Recombinant Monoclonal Antibody	CSB-RA004888A0HU	CD19	Human	ELISA
CD19 Recombinant Monoclonal Antibody	CSB-RA780821A0HU	CD19	Human	ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody	CSB-RA004888MA1HU	CD19	Human, Mouse	ELISA, WB
CD22 Recombinant Monoclonal Antibody	CSB-RA962691A0HU	CD22	Human	ELISA, IHC
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD34 Recombinant Monoclonal Antibody	CSB-RA004926A0HU	CD34	Human	ELISA, IHC
CD38 Recombinant Monoclonal Antibody	CSB-RA796695A0HU	CD38	Human	ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody	CSB-RA004931MA1HU	CD3E	Human	ELISA, FC
CD4 Recombinant Monoclonal Antibody	CSB-RA004935A0HU	CD4	Human	ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody	CSB-RA004954MA1HU	CD70	Human	ELISA
CD80 Recombinant Monoclonal Antibody	CSB-RA246383A0HU	CD80	Human	ELISA, WB, IHC, IP
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC

● ELISA試劑盒

產品名稱	貨號	靶點	檢測范圍	靈敏度
Bovine Albumin(Alb) ELISA kit	CSB-E08664b	ALB	0.313 μg/mL-80 μg/mL	0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit	CSB-E13878m	ALB	0.781 μg/mL-200 μg/mL	0.110 μg/mL
Dog Albumin(Alb) ELISA Kit	CSB-E15757c	ALB	0.273 μg/mL-35 μg/mL	0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit	CSB-E15839Sh	ALB	350 μg/mL-21.88 μg/mL	5.5 μg/mL
Horse Albumin(Alb) ELISA Kit	CSB-E16205Hs	ALB	1.25 μg/mL-80 μg/mL	1.247 μg/mL
Pig Albumin (Alb) ELISA Kit	CSB-E16207p	ALB	0.03 μg/mL-7000 μg/mL	0.03 μg/mL
Goat Albumin (Alb)ELISA Kit	CSB-E15758G	ALB	0.17 μg/mL-350 μg/mL	0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit	CSB-E15765Gp	ALB	0.156 μg/mL-10 μg/mL	0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit	CSB-E16204Rb	ALB	0.273 μg/mL-70 μg/mL	0.117 μg/mL
Human Complement 3,C3 ELISA Kit	CSB-E08665h	C3	4.7 ng/mL-300 ng/mL	4.031 ng/mL
Pig Complement 3,C3 ELISA Kit	CSB-E06920p	C3	0.625 μg/mL-10 μg/mL	0.625 μg/mL
Rat Complement 3,C3 ELISA Kit	CSB-E08666r	C3	0.625 μg/mL-40 μg/mL	0.156 μg/mL
Mouse Complement 3,C3 ELISA Kit	CSB-E08667m	C3	93.75 ng/mL-6000 ng/mL	23.44 ng/mL
Rabbit Complement 3,C3 ELISA Kit	CSB-E08668Rb	C3	27.3 ng/mL-7000 ng/mL	27.3 ng/mL
Fish Complement 3,C3 ELISA Kit	CSB-E09727s	C3	12.5 μg/mL-500 μg/mL	12.5 μg/mL
Monkey Complement 3(C3)ELISA Kit	CSB-E16528Mk	C3	4.68 ng/mL-300 ng/mL	1.17 ng/mL
Dog Complement 3(C3)ELISA Kit	CSB-EL003888DO	C3	0.78 μg/mL-50 μg/mL	0.195 μg/mL
Mouse Complement 5,C5 ELISA Kit	CSB-E13802m	C5	0.25 ng/mL-16 ng/mL	0.06 ng/mL
Rat Complement fragment 5,C5 ELISA Kit	CSB-E14363r	C5	9.38 ng/mL-600 ng/mL	2.34 ng/mL
Monkey complement C5 (C5) ELISA kit	CSB-EL003995MK	C5	0.625 ng/mL-40 ng/mL	0.156 ng/mL