IFNAR1
IFNAR1，即干擾素α和β受體亞單位1，別名Interferon beta receptor 1、interferon receptor 1、Interferon-alpha receptor、Type I interferon receptor 1。它是一種I型干擾素受體的組成部分，由人體細(xì)胞自身的基因編碼。IFNAR1的作用機(jī)制主要是與IFNAR2亞單位形成異二聚體受體，與干擾素α和β結(jié)合后，激活Janus激酶(JAK)，進(jìn)而激活信號(hào)轉(zhuǎn)導(dǎo)及轉(zhuǎn)錄激活因子(STAT)信號(hào)通路，尤其是通過(guò)磷酸化STAT1和STAT2，形成ISGF3復(fù)合體，促進(jìn)干擾素刺激基因(ISGs)的表達(dá)。在生物學(xué)意義上，IFNAR1在機(jī)體的抗病毒反應(yīng)和免疫調(diào)節(jié)中發(fā)揮關(guān)鍵作用。它不僅參與了對(duì)病毒感染的防御機(jī)制，還與腫瘤免疫、自身免疫性疾病的發(fā)生發(fā)展有關(guān)。例如，IFNAR1介導(dǎo)的信號(hào)通路可以增強(qiáng)NK細(xì)胞的活性，促進(jìn)單核細(xì)胞和巨噬細(xì)胞的功能，以及刺激樹(shù)突狀細(xì)胞的成熟和遷移。此外，IFNAR1的功能異常可能與某些病毒性疾病的發(fā)病機(jī)制相關(guān)，使其成為抗病毒治療和免疫調(diào)節(jié)治療的潛在靶點(diǎn) 。
熱銷產(chǎn)品
IFNAR1 Antibody (CSB-PA107635)
驗(yàn)證數(shù)據(jù)
Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200
IFNAR1 Antibodies
IFNAR1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011046GA01HU | IFNAR1 Antibody | Human | ELISA,WB |
| CSB-PA009471 | Phospho-IFNAR1 (Y466) Antibody | Human | WB, IHC, ELISA |
| CSB-PA009473 | IFNAR1 Antibody | Human | IHC, IF, ELISA |
| CSB-PA107635 | IFNAR1 Antibody | Human | IHC,ELISA |
| CSB-RA011046A0HU | IFNAR1 Recombinant Monoclonal Antibody | Human | ELISA |
IFNAR1 Proteins
IFNAR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011046HU1 CSB-EP011046HU CSB-BP011046HU CSB-MP011046HU CSB-EP011046HU1-B |
Recombinant Human Interferon alpha/beta receptor 1 (IFNAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011046HU | Recombinant Human Interferon alpha/beta receptor 1 (IFNAR1) | in vitro E.coli expression system |
IFNAR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011046MO1 CSB-EP011046MO1 CSB-BP011046MO1 CSB-MP011046MO1 CSB-EP011046MO1-B |
Recombinant Mouse Interferon alpha/beta receptor 1 (Ifnar1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011046MO | Recombinant Mouse Interferon alpha/beta receptor 1 (Ifnar1) | in vitro E.coli expression system |
IFNAR1 Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP636729SH CSB-EP636729SH CSB-BP636729SH CSB-MP636729SH CSB-EP636729SH-B |
Recombinant Sheep Interferon alpha/beta receptor 1 (IFNAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNAR1 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP758824PI CSB-EP758824PI CSB-BP758824PI CSB-MP758824PI CSB-EP758824PI-B |
Recombinant Pig Interferon alpha/beta receptor 1 (IFNAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
