FOLR1
FOLR1（葉酸受體1）是一種成人葉酸受體，也稱為葉酸結合蛋白（FBP），由FOLR1基因編碼。這種膜結合糖蛋白對葉酸和幾種還原葉酸衍生物具有高親和力，主要功能是介導5-甲基四氫葉酸的細胞內運輸，對細胞生長和增殖至關重要。FOLR1的結構包括跨膜結構域，并存在膜結合和可溶性兩種形式。 除了在葉酸轉運中的基本作用外，FOLR1還參與了多種信號通路，包括JAK-STAT3、ERK1/2信號通路，并可能作為轉錄因子參與基因表達調控。FOLR1在Wnt和ERK信號通路中發揮作用，通過增加活性β-catenin、磷酸化ERK以及Wnt和ERK調控基因的表達。此外，FOLR1還可能參與Wnt和TGFβ信號通路。 FOLR1的異常表達與多種癌癥的發生、發展密切相關，其在腫瘤細胞中的高表達通常與癌癥進展加快和患者預后不良有關。因此，FOLR1不僅是癌癥治療研究中的潛在靶點，而且在葉酸受體靶向治療領域具有重要的應用前景。
熱銷產品
Recombinant Human Folate receptor alpha(FOLR1),partial (Active) (CSB-MP008784HU1)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized human FOLR1 at 2 μg/ml can bind Anti-FOLR1 recombinant antibody(CSB-RA008784MA1HU). The EC50 is 6.893-7.883 ng/mL.
The purity of FOLR1 was greater than 95% as determined by SEC-HPLC
Recombinant Macaca fascicularis Folate receptor alpha(FOLR1),partial (Active) (CSB-MP5002MOV)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus FOLR1 at 2 μg/ml can bind Anti-FOLR1 recombinant antibody(CSB-RA008784MA1HU). The EC50 is 2.900-3.544 ng/mL.
FOLR1 Antibodies
FOLR1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA008378 | FOLR1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008784LA01HU | FOLR1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA008784LB01HU | FOLR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008784LC01HU | FOLR1 Antibody, FITC conjugated | Human | |
| CSB-PA008784LD01HU | FOLR1 Antibody, Biotin conjugated | Human | ELISA |
FOLR1 Proteins
FOLR1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008784HU CSB-EP008784HU CSB-MP008784HU CSB-EP008784HU-B |
Recombinant Human Folate receptor alpha (FOLR1) | Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP008784HU1 | Recombinant Human Folate receptor alpha(FOLR1),partial (Active) | Mammalian cell |
FOLR1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008784MO CSB-EP008784MO CSB-BP008784MO CSB-MP008784MO CSB-EP008784MO-B |
Recombinant Mouse Folate receptor alpha (Folr1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOLR1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008784BO CSB-EP008784BO CSB-BP008784BO CSB-MP008784BO CSB-EP008784BO-B |
Recombinant Bovine Folate receptor alpha (FOLR1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOLR1 ELISA Kit
FOLR1 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL008784HU | Human Folate receptor alpha(FOLR1) ELISA kit | serum, plasma, tissue homogenates | 0.09 ng/ml |
