DLL3 Recombinant Monoclonal Antibody
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中文名稱：DLL3重組抗體
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貨號：CSB-RA882142A1HU
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規格：￥1320
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圖片：
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Untransfected HEK293 cells surface (green line) and transfected Human DLL3 HEK293 stable cells surface (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μl/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry. -
The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP3536MOV) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.625-2.702 ng/mL. -
The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP882142HU) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL. -
The purity of DLL3 was greater than 95% as determined by SEC-HPLC
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其他：
產品詳情
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產品描述：DLL3重組單克隆抗體（CSB-RA882142A1HU）是針對Delta樣配體3（DLL3）靶點開發的高特異性科研用抗體。DLL3作為Notch信號通路的關鍵調控分子，在細胞分化、組織發育及腫瘤發生中發揮重要作用，尤其在神經內分泌腫瘤和小細胞肺癌等疾病中呈現異常表達特征。本產品采用重組表達技術制備，經ELISA和流式細胞術（FC）嚴格驗證，在FC應用中表現出優異的靈敏度和重復性，推薦使用稀釋比例為1:50-1:200，可精準識別天然構象的DLL3蛋白。其均一的單克隆特性確保了實驗數據的穩定性和可重復性，適用于細胞表面蛋白定量分析、腫瘤細胞亞群分選、信號通路調控機制研究等領域?？蒲腥藛T可通過該抗體開展DLL3相關分子機制研究、體外藥物靶點篩選及腫瘤標志物檢測等實驗，為腫瘤生物學研究和抗腫瘤藥物開發提供可靠工具。本品嚴格遵循質量控制標準，適用于體外實驗體系，不涉及活體診斷或治療用途。
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Uniprot No.：
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基因名：
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別名：Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3), DLL3
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反應種屬：Human
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免疫原：Recombinant Human DLL3 protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：hIgG1
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純化方式：Affinity-chromatography
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克隆號：7B7
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, FC
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推薦稀釋比：
Application Recommended Dilution FC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
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基因功能參考文獻：
- these results reveal that DLL3 is expressed in tumor specimens from most patients with small cell lung cancer PMID: 29290251
- Results indicated that DLL3 expression was silenced in hepatocellular carcinoma (HCC) cells by DNA methylation and was more readily affected by histone acetylation than histone methylation (H3K9me2 or H3K27me3). PMID: 29512761
- our results indicated epidermal growth factor-like domain multiple 7 protein participates in growth hormone-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 signaling pathway. These findings raised the possibility that epidermal growth factor-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone-secreting pituitary adenoma invasion and prognosis PMID: 28705113
- The Dll3 was rarely detectable in the para-carcinoma tissues, but positive in 82.1% of non-small cell cancer tissues. PMID: 28007595
- Both global haplotype and individual haplotype analyses showed that the haplotypes of SNP1/SNP2/SNP3/SNP4/SNP5 did not correlate with the disease (P >0.05). Together, these data suggest that genetic variants of the DLL3 gene are not associated with CS in the Chinese Han population. PMID: 27472720
- DLL3 was silenced by methylation in human human hepatocellular carcinoma and it negatively regulates the growth of human hepatocellular carcinoma cells. PMID: 23337976
- We suggest that the three human DLL3 mutations associated with spondylocostal dysplasia are also functionally equivalent to the Dll3(neo) null allele in mice. PMID: 11923214
- mutations in DLL3 cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis PMID: 12746394
- no novel or previously described mutations are present in our cohort, indicating that DLL3 mutations may not be a major cause of congenital scoliosis. PMID: 15717203
- The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity PMID: 18676613
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相關疾病：Spondylocostal dysostosis 1, autosomal recessive (SCDO1)
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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數據庫鏈接：
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