DLL3 Recombinant Monoclonal Antibody
-
中文名稱：DLL3重組抗體
-
貨號(hào)：CSB-RA882142A1HU
-
規(guī)格：￥1320
-
圖片：
-
Untransfected HEK293 cells surface (green line) and transfected Human DLL3 HEK293 stable cells surface (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μl/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry. -
The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP3536MOV) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.625-2.702 ng/mL. -
The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP882142HU) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL. -
The purity of DLL3 was greater than 95% as determined by SEC-HPLC
-
-
其他：
產(chǎn)品詳情
-
產(chǎn)品描述：DLL3重組單克隆抗體（CSB-RA882142A1HU）是針對(duì)Delta樣配體3（DLL3）靶點(diǎn)開發(fā)的高特異性科研用抗體。DLL3作為Notch信號(hào)通路的關(guān)鍵調(diào)控分子，在細(xì)胞分化、組織發(fā)育及腫瘤發(fā)生中發(fā)揮重要作用，尤其在神經(jīng)內(nèi)分泌腫瘤和小細(xì)胞肺癌等疾病中呈現(xiàn)異常表達(dá)特征。本產(chǎn)品采用重組表達(dá)技術(shù)制備，經(jīng)ELISA和流式細(xì)胞術(shù)（FC）嚴(yán)格驗(yàn)證，在FC應(yīng)用中表現(xiàn)出優(yōu)異的靈敏度和重復(fù)性，推薦使用稀釋比例為1:50-1:200，可精準(zhǔn)識(shí)別天然構(gòu)象的DLL3蛋白。其均一的單克隆特性確保了實(shí)驗(yàn)數(shù)據(jù)的穩(wěn)定性和可重復(fù)性，適用于細(xì)胞表面蛋白定量分析、腫瘤細(xì)胞亞群分選、信號(hào)通路調(diào)控機(jī)制研究等領(lǐng)域。科研人員可通過(guò)該抗體開展DLL3相關(guān)分子機(jī)制研究、體外藥物靶點(diǎn)篩選及腫瘤標(biāo)志物檢測(cè)等實(shí)驗(yàn)，為腫瘤生物學(xué)研究和抗腫瘤藥物開發(fā)提供可靠工具。本品嚴(yán)格遵循質(zhì)量控制標(biāo)準(zhǔn)，適用于體外實(shí)驗(yàn)體系，不涉及活體診斷或治療用途。
-
Uniprot No.：
-
基因名：
-
別名：Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3), DLL3
-
反應(yīng)種屬：Human
-
免疫原：Recombinant Human DLL3 protein
-
免疫原種屬：Homo sapiens (Human)
-
標(biāo)記方式：Non-conjugated
-
克隆類型：Monoclonal
-
抗體亞型：hIgG1
-
純化方式：Affinity-chromatography
-
克隆號(hào)：7B7
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
-
應(yīng)用范圍：ELISA, FC
-
推薦稀釋比：
Application Recommended Dilution FC 1:50-1:200 -
Protocols：
-
儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能：Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
-
基因功能參考文獻(xiàn)：
- these results reveal that DLL3 is expressed in tumor specimens from most patients with small cell lung cancer PMID: 29290251
- Results indicated that DLL3 expression was silenced in hepatocellular carcinoma (HCC) cells by DNA methylation and was more readily affected by histone acetylation than histone methylation (H3K9me2 or H3K27me3). PMID: 29512761
- our results indicated epidermal growth factor-like domain multiple 7 protein participates in growth hormone-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 signaling pathway. These findings raised the possibility that epidermal growth factor-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone-secreting pituitary adenoma invasion and prognosis PMID: 28705113
- The Dll3 was rarely detectable in the para-carcinoma tissues, but positive in 82.1% of non-small cell cancer tissues. PMID: 28007595
- Both global haplotype and individual haplotype analyses showed that the haplotypes of SNP1/SNP2/SNP3/SNP4/SNP5 did not correlate with the disease (P >0.05). Together, these data suggest that genetic variants of the DLL3 gene are not associated with CS in the Chinese Han population. PMID: 27472720
- DLL3 was silenced by methylation in human human hepatocellular carcinoma and it negatively regulates the growth of human hepatocellular carcinoma cells. PMID: 23337976
- We suggest that the three human DLL3 mutations associated with spondylocostal dysplasia are also functionally equivalent to the Dll3(neo) null allele in mice. PMID: 11923214
- mutations in DLL3 cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis PMID: 12746394
- no novel or previously described mutations are present in our cohort, indicating that DLL3 mutations may not be a major cause of congenital scoliosis. PMID: 15717203
- The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity PMID: 18676613
顯示更多
收起更多
-
相關(guān)疾病：Spondylocostal dysostosis 1, autosomal recessive (SCDO1)
-
亞細(xì)胞定位：Membrane; Single-pass type I membrane protein.
-
數(shù)據(jù)庫(kù)鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
