DRD4
DRD4，即多巴胺受體D4，別名D(4 dopamine receptor、D(2C dopamine receptor、Dopamine D4 receptor。它是一種G蛋白偶聯(lián)受體，屬于多巴胺受體家族成員之一，由人體細(xì)胞自身的DRD4基因編碼。DRD4在大腦的邊緣系統(tǒng)中表達(dá)，特別是與情緒和復(fù)雜行為調(diào)節(jié)相關(guān)的區(qū)域。其作用機(jī)制是通過與多巴胺等配體結(jié)合，激活G蛋白，進(jìn)而抑制腺苷酸環(huán)化酶的活性，影響細(xì)胞內(nèi)的信號傳遞。DRD4參與調(diào)節(jié)情緒、認(rèn)知功能、注意力以及成癮行為等。研究表明，DRD4的多態(tài)性與多種心理和神經(jīng)發(fā)育障礙有關(guān)，例如注意缺陷多動障礙(ADHD)、精神分裂癥、肥胖和吸煙成癮等。此外，DRD4的活性還與晝夜節(jié)律的調(diào)節(jié)有關(guān)，它通過調(diào)節(jié)視網(wǎng)膜神經(jīng)節(jié)細(xì)胞中NPAS2的節(jié)律性表達(dá)，影響對比敏感度的晝夜節(jié)律。因此，DRD4是神經(jīng)科學(xué)研究和相關(guān)疾病治療中的一個潛在靶點。
熱銷產(chǎn)品
驗證數(shù)據(jù)
Western Blot analysis of K562 cells using D4DR Polyclonal Antibody
Western Blot analysis of K562 cells using D4DR Polyclonal Antibody
DRD4 Antibodies
DRD4 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002055 | DRD4 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA967891 | DRD4 Antibody | Human | ELISA,WB,IHC |
| CSB-PA695604 | DRD4 Antibody | Human,Mouse | ELISA,WB,IHC |
DRD4 Proteins
DRD4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007181HU1 CSB-EP007181HU1 CSB-BP007181HU1 CSB-MP007181HU1 CSB-EP007181HU1-B |
Recombinant Human D (4) dopamine receptor (DRD4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007181HU | Recombinant Human D (4) dopamine receptor (DRD4) | in vitro E.coli expression system |
DRD4 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007181RA1 CSB-EP007181RA1 CSB-BP007181RA1 CSB-MP007181RA1 CSB-EP007181RA1-B |
Recombinant Rat D (4) dopamine receptor (Drd4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007181RA | Recombinant Rat D (4) dopamine receptor (Drd4) | in vitro E.coli expression system |
DRD4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007181MO1 CSB-EP007181MO1 CSB-BP007181MO1 CSB-MP007181MO1 CSB-EP007181MO1-B |
Recombinant Mouse D (4) dopamine receptor (Drd4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007181MO | Recombinant Mouse D (4) dopamine receptor (Drd4) | in vitro E.coli expression system |
DRD4 Proteins for Mustela putorius furo (European domestic ferret) (Mustela furo)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP754376MOH1 CSB-EP754376MOH1 CSB-BP754376MOH1 CSB-MP754376MOH1 CSB-EP754376MOH1-B |
Recombinant Mustela putorius furo D (4) dopamine receptor (DRD4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF754376MOH | Recombinant Mustela putorius furo D (4) dopamine receptor (DRD4) | in vitro E.coli expression system |
