白血病

白血病是一種影響血液和骨髓的惡性腫瘤，它導(dǎo)致體內(nèi)產(chǎn)生大量未成熟或異常的白細(xì)胞，這些異常細(xì)胞可能會抑制正常血細(xì)胞的產(chǎn)生，從而引發(fā)各種癥狀和并發(fā)癥。白血病可以分為急性和慢性兩大類，根據(jù)細(xì)胞類型又可分為髓系和淋巴系兩種。急性白血病的細(xì)胞分化停滯在早期階段，疾病發(fā)展迅速；而慢性白血病的細(xì)胞分化較好，發(fā)展緩慢。

白血病的藥物研發(fā)近年來取得了顯著進(jìn)展。例如，靶向治療藥物如酪氨酸激酶抑制劑（TKI）在慢性髓系白血病（CML）的治療中取得了巨大成功，極大地改善了患者的預(yù)后。特別是三代TKI新藥的問世，為CML患者提供了更多的治療選擇和更好的療效。

此外，CAR-T細(xì)胞療法作為一種新興的免疫治療方法，已經(jīng)在某些類型的白血病治療中顯示出突破性的療效。CAR-T療法通過改造患者的T細(xì)胞，使其能夠識別并攻擊癌細(xì)胞。中國在CAR-T療法的研發(fā)上也取得了進(jìn)展，已有產(chǎn)品獲批上市，為患者提供了新的治療選擇。

全球范圍內(nèi)，針對白血病治療的藥物研發(fā)非常活躍，處于在研階段的藥物有上千個。其中靶向CD19的藥物數(shù)量最多，其次是Flt3抑制劑。中國在白血病治療藥物研發(fā)方面也取得了進(jìn)展，例如，基石藥業(yè)的艾伏尼布（Ivosidenib）在中國的注冊研究顯示了明確的療效和可控的安全性，有望成為中國首個獲批的IDH1抑制劑。

白血病藥物靶點(diǎn)

白血病藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

MS4A1
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL

CD22
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC₅₀ of human CD22 protein is 4.034-4.800 ng/ml.

CD33
CSB-MP004925HU

Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC₅₀ of human CD33 protein is 4.289- 5.312 ng/ml.

CD47
CSB-MP004940HU

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

TNFRSF8
CSB-MP023983HU1

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L(CSB-MP023996HU1c9), the EC₅₀ is 14.96-20.25 ng/ml

CD40
CSB-MP004936HU1

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay

產(chǎn)品名稱	貨號	靶點(diǎn)	來源	蛋白標(biāo)簽
Recombinant Human C-C chemokine receptor type 4 (CCR4)-VLPs (Active)	CSB-MP004843HU	CCR4	Mammalian cell	C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	CSB-AP005061HU	CD19	Mammalian cell	C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active)	CSB-MP004900HU	CD22	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active)	CSB-MP004925HU	CD33	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial (Active)	CSB-MP004938HU(F1)	CD44	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial, Biotinylated (Active)	CSB-MP004938HU(F1)j1-B	CD44	Mammalian cell	C-terminal mFc-Avi-tagged
Recombinant Macaca fascicularis CD44 antigen (CD44), partial (Active)	CSB-MP4290MOV	CD44	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human T-cell antigen CD7 (CD7), partial (Active)	CSB-MP004953HU	CD7	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active)	CSB-MP004954HU1	CD70	Mammalian cell	N-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active)	CSB-AP003591HU	CSF2RA	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	Ctla4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-MP006163HU1	CTLA4	Mammalian cell	C-terminal hFc-tagged

● 穩(wěn)定細(xì)胞株

CSB-SC004843HU2

HEK293T/Human CCR4 Stable Cell Line

Untransfected HEK293T cells (green line) and transfected Human CCR4 HEK293T stable cells (red line) were stained with anti-CCR4 antibody (CSB-MA236376) (2μg/1*10⁶), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-SC020067HU

CT26/Human ROR1 Stable Cell Line

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

CCR4 Recombinant Monoclonal Antibody
CSB-RA004843MA01HU

Untransfected HEK293 cells surface (green line) and transfected Human CCR4 HEK293 stable cells surface (red line) were stained with anti-CCR4 antibody (2μl/1*10⁶ cells)

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CD3E Recombinant Monoclonal Antibody
CSB-RA004931MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.

CD44 Recombinant Monoclonal Antibody
CSB-RA004938MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA004938MA1HU (red line) at 1:100.

產(chǎn)品名稱	貨號	靶點(diǎn)	反應(yīng)種屬	應(yīng)用范圍
CCR4 Recombinant Monoclonal Antibody	CSB-RA004843MA01HU	CCR4	Human	ELISA, FC
CD19 Recombinant Monoclonal Antibody	CSB-RA004888A0HU	CD19	Human	ELISA
CD19 Recombinant Monoclonal Antibody	CSB-RA780821A0HU	CD19	Human	ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody	CSB-RA004888MA1HU	CD19	Human, Mouse	ELISA, WB
CD22 Recombinant Monoclonal Antibody	CSB-RA962691A0HU	CD22	Human	ELISA, IHC
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody	CSB-RA796695A0HU	CD38	Human	ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody	CSB-RA004931MA1HU	CD3E	Human	ELISA, FC
CD4 Recombinant Monoclonal Antibody	CSB-RA004935A0HU	CD4	Human	ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD44 Recombinant Monoclonal Antibody	CSB-RA004938A0HU	CD44	Human	ELISA, WB, IHC
CD44 Recombinant Monoclonal Antibody	CSB-RA292372A0HU	CD44	Human	ELISA, WB, IHC, IF, FC
CD44 Recombinant Monoclonal Antibody	CSB-RA004938MA1HU	CD44	Human	ELISA, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody	CSB-RA004954MA1HU	CD70	Human	ELISA
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
CXCR4 Recombinant Monoclonal Antibody	CSB-RA569311A0HU	CXCR4	Human	ELISA, IF

● ELISA試劑盒

產(chǎn)品名稱	貨號	靶點(diǎn)	檢測范圍	靈敏度
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human Myeloid cell surface antigen CD33(CD33) ELISA kit	CSB-EL004925HU	CD33	125 pg/mL-8000 pg/mL	31.25 pg/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit	CSB-E09884h	CD38	0.9 ng/mL-60 ng/mL	0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit	CSB-EL004929MO	CD38	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human cluster of differentiation 4,CD4 ELISA Kit	CSB-E08956h	CD4	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Rat cluster of differentiation 4,CD4 ELISA Kit	CSB-E12928r	CD4	0.78 U/mL-50 U/mL	0.195 U/mL
Chicken Cluster of Differentiation 4(CD4) ELISA Kit	CSB-E13114C	CD4	3.125 ng/mL-800 ng/mL	3.125 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit	CSB-EL004936MO	CD40	Request Information	Request Information
Human cluster Of differentiation,CD44 ELISA Kit	CSB-E11846h	CD44	78 pg/mL-5000 pg/mL	19.5 pg/mL
Human Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940HU	CD47	3.12 pg/mL-200 pg/mL	0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940MO	CD47	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Human CAMPATH-1 antigen(CD52) ELISA kit	CSB-EL004943HU	CD52	78 ng/mL-5000 ng/mL	19.5 ng/mL
Mouse cluster of differentiation 6(CD6) ELISA Kit	CSB-EL004949MO	CD6	Request Information	Request Information
Human CD70 antigen(CD70) ELISA kit	CSB-EL004954HU	CD70	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Mouse CD70 antigen(CD70) ELISA kit	CSB-EL004954MO	CD70	Request Information	Request Information
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E09171h	CTLA4	125 pg/mL-8000 pg/mL	31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E13637m	CTLA4	0.312 ng/mL-20 ng/mL	0.078 ng/mL
Rat CXC-chemokine receptor 4(CXCR4)ELISA Kit	CSB-E12703r	CXCR4	0.156 ng/mL-10 ng/mL	0.039 ng/mL