TNFSF15
TNFSF15，也稱為血管內皮生長抑制因子（VEGI）或TL1A，是由TNFSF15基因編碼的蛋白質，位于染色體9q32上。該蛋白質由251個氨基酸組成，包含胞質結構域、跨膜域和胞外結構域，并能形成穩定的同源三聚體結構。TNFSF15主要作為死亡受體3（DR3）的配體，參與調控VEGF/VEGFR信號通路，影響內皮細胞的增殖、凋亡以及淋巴管生成等過程。它在血管生成、淋巴管形成、免疫調節等多個方面發揮重要作用，并為涉及血管通透性增加的病理過程（如腫瘤、腦卒中等）的治療提供了新的靶點。
更多相關閱讀：TNFSF15/TL1A：藥企巨頭搶灘布局，下一個百億級靶點的崛起之路
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 at 2 μg/ml on streptavidin coated plates can bind Anti-TNFSF15 antibody (CSB-RA023992MA1HU). The EC50 is 0.2732 - 0.6370 ng/mL.
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Anti-TNFSF15 recombinant antibody (CSB-RA023992MA1HU) at 2 μg/ml can bind Biotinylated Macaca mulatta TNFSF15. The EC50 is 0.2589-0.3025 ng/mL.
TNFSF15 Recombinant Monoclonal Antibody (CSB-RA023992MA1HU)
驗證數據
The Binding Activity of Biotinylated Macaca mulatta TNFSF15 with Anti-TNFSF15 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-TNFSF15 recombinant antibody at 2 μg/mL can bind Biotinylated Macaca mulatta TNFSF15 (CSB-MP5305MOW-B). The EC50 is 0.2589-0.3025 ng/mL.
The Binding Activity of Biotinylated TNFSF15 with Anti-TNFSF15 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Biotinylated Human TNFSF15 at 2 μg/mL on streptavidin coated plates can bind Anti-TNFSF15 recombinant antibody (CSB-RA023992MA1HU). The EC50 is 0.2732 - 0.6370 ng/mL.
The Binding Activity of Mouse Tnfsf15 with Anti-TNFSF15 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Tnfsf15 (CSB-MP729268MO) at 2 μg/mL can bind Anti-TNFSF15 recombinant antibody. The EC50 is 1.671-2.506 ng/mL.
TNFSF15 Antibodies
TNFSF15 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA983205 | TNFSF15 Antibody | Human | ELISA,WB,IF |
| CSB-PA004447 | TNFSF15 Antibody | Human | WB, IF, ELISA |
| CSB-PA577745 | TNFSF15 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA065340 | TNFSF15 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA023992ESR1HU | TNFSF15 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA023992ESR2HU | TNFSF15 Antibody | Human | ELISA, IHC |
| CSB-RA023992MA1HU | TNFSF15 Recombinant Monoclonal Antibody | Human, Cynomolgus, Mouse | ELISA |
TNFSF15 Proteins
TNFSF15 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023992HU1 CSB-EP023992HU1 CSB-BP023992HU1 CSB-EP023992HU1-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 15 (TNFSF15), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP002341HU | Recombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15), partial (Active) | E.Coli |
| CSB-CF023992HU | Recombinant Human Tumor necrosis factor ligand superfamily member 15 (TNFSF15) | in vitro E.coli expression system |
| CSB-AP004991HU | Recombinant Human Tumor necrosis factor ligand superfamily member 15 (TNFSF15) (Active) | E.coli |
| CSB-MP023992HU(F2) | Recombinant Human Tumor necrosis factor ligand superfamily member 15(TNFSF15) (Active) | Mammalian cell |
| CSB-MP023992HU1-B | Recombinant Human Tumor necrosis factor ligand superfamily member 15(TNFSF15),partial,Biotinylated (Active) | Mammalian cell |
TNFSF15 ELISA Kit
TNFSF15 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E15770h | Human tumor necrosis factor superfamily 15 (TL1A/TNFSF15) ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.195 ng/mL |
