女性泌尿生殖器疾病和妊娠并發(fā)癥

女性泌尿生殖器疾病和妊娠并發(fā)癥是影響女性健康的重要問(wèn)題。這些疾病包括但不限于尿路感染、陰道炎、子宮內(nèi)膜異位癥、子宮肌瘤、妊娠期糖尿病、妊娠高血壓等。

女性泌尿生殖器疾病中，尿路感染和陰道炎較為常見(jiàn)，這些疾病通常由細(xì)菌、真菌或病毒引起。治療這些疾病的藥物主要包括抗生素、抗真菌藥和抗病毒藥。此外，雌激素替代療法也被用于治療與絕經(jīng)相關(guān)的泌尿生殖系統(tǒng)癥狀。
妊娠并發(fā)癥包括妊娠期糖尿病、妊娠高血壓、子癇前期等，這些疾病對(duì)孕婦和胎兒的健康構(gòu)成重大風(fēng)險(xiǎn)。治療妊娠并發(fā)癥的藥物研發(fā)主要集中在控制血糖、血壓和改善胎兒生長(zhǎng)等方面。

女性泌尿生殖器疾病和妊娠并發(fā)癥藥物靶點(diǎn)

女性泌尿生殖器疾病和妊娠并發(fā)癥相關(guān)信號(hào)通路

Hippo信號(hào)通路在細(xì)胞增殖、分化、遷移和凋亡中起關(guān)鍵作用。研究表明，miR21通過(guò)干擾PP2A Bb調(diào)節(jié)Hippo信號(hào)通路，進(jìn)而抑制滋養(yǎng)層細(xì)胞侵襲，與子癇前期(PE)的發(fā)病機(jī)制有關(guān) ^[1]。

Jak-STAT signaling pathway

異常的STAT信號(hào)傳導(dǎo)與妊娠疾病的發(fā)生有關(guān)，包括反復(fù)著床失敗、先兆子癇、反復(fù)自然流產(chǎn)、早產(chǎn)和妊娠期糖尿病等 ^[2]。

Notch signaling pathway

Notch信號(hào)通路影響滋養(yǎng)細(xì)胞的分化、增殖、浸潤(rùn)及遷移，參與胚胎著床、胎盤(pán)及其血管形成，與妊娠相關(guān)疾病的發(fā)生與發(fā)展有關(guān) ^[3]。

女性泌尿生殖器疾病和妊娠并發(fā)癥靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

ERBB2 (HER2)
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.

GHR
CSB-MP009411HU

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

IL2RA
CSB-MP011649HU3

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU)，the EC₅₀ is 2.463-3.353 ng/mL.

CTLA4
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

EGFR
CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

MSLN
CSB-MP015044HUc9

Measured by its binding ability in a functional ELISA. Immobilized MSLN at 2 μg/ml can bind Anti-MSLN rabbit monoclonal antibody, the EC₅₀ of the MSLN protein is 2.657-3.177 ng/ml.

產(chǎn)品名稱(chēng)	貨號(hào)	靶點(diǎn)	來(lái)源	蛋白標(biāo)簽
Recombinant Human Angiopoietin-2 (ANGPT2) (Active)	CSB-MP001707HU(A4)	ANGPT2	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active)	CSB-MP001707DO	ANGPT2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	CSB-AP005061HU	CD19	Mammalian cell	C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active)	CSB-MP004900HU	CD22	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active)	CSB-MP733578HU	CD276	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-AP005191HU	CD40LG	E.coli	Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-MP004937HU3	CD40LG	Mammalian cell	N-terminal hFc-Flag-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active)	CSB-MP004954HU1	CD70	Mammalian cell	N-terminal 10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active)	CSB-MP005165HU	CEACAM5	Mammalian cell	C-terminal?10xHis-tagged
Recombinant Human Claudin-6 (CLDN6)-VLPs (Active)	CSB-MP005508HU(A4)	CLDN6	Mammalian cell	C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active)	CSB-MP005508HU(A4)f4	CLDN6	Mammalian cell	C-terminal GFP-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active)	CSB-AP003591HU	CSF2RA	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged

● 穩(wěn)定細(xì)胞株

HEK293T/Human CLDN6 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

HEK293T/Human ENPP3 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human ENPP3 HEK293T Stable cells (red line) were stained with anti-ENPP3 antibody (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

產(chǎn)品名稱(chēng)	貨號(hào)	靶點(diǎn)	反應(yīng)種屬	應(yīng)用范圍
ALB Recombinant Monoclonal Antibody	CSB-RA264109A0HU	ALB	Human	ELISA, FC
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA191985A0HU	ANGPT2	Human	ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA001707MA01HU	ANGPT2	Human	ELISA
C5 Recombinant Monoclonal Antibody	CSB-RA003995MA1HU	C5	Human	ELISA, FC
CA9 Recombinant Monoclonal Antibody	CSB-RA614990A0HU	CA9	Human	ELISA, IHC
CD19 Recombinant Monoclonal Antibody	CSB-RA004888A0HU	CD19	Human	ELISA
CD19 Recombinant Monoclonal Antibody	CSB-RA780821A0HU	CD19	Human	ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody	CSB-RA004888MA1HU	CD19	Human, Mouse	ELISA, WB
CD22 Recombinant Monoclonal Antibody	CSB-RA962691A0HU	CD22	Human	ELISA, IHC
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody	CSB-RA796695A0HU	CD38	Human	ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody	CSB-RA004954MA1HU	CD70	Human	ELISA
CD80 Recombinant Monoclonal Antibody	CSB-RA246383A0HU	CD80	Human	ELISA, WB, IHC, IP
CDH6 Recombinant Monoclonal Antibody	CSB-RA005055MA1HU	CDH6	Human	ELISA
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA3HU	CEACAM5	Human	ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA1HU	CEACAM5	Human	ELISA

● ELISA試劑盒

產(chǎn)品名稱(chēng)	貨號(hào)	靶點(diǎn)	檢測(cè)范圍	靈敏度
Bovine Albumin(Alb) ELISA kit	CSB-E08664b	ALB	0.313 μg/mL-80 μg/mL	0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit	CSB-E13878m	ALB	0.781 μg/mL-200 μg/mL	0.110 μg/mL
Dog Albumin(Alb) ELISA Kit	CSB-E15757c	ALB	0.273 μg/mL-35 μg/mL	0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit	CSB-E15839Sh	ALB	350 μg/mL-21.88 μg/mL	5.5 μg/mL
Horse Albumin(Alb) ELISA Kit	CSB-E16205Hs	ALB	1.25 μg/mL-80 μg/mL	1.247 μg/mL
Pig Albumin (Alb) ELISA Kit	CSB-E16207p	ALB	0.03 μg/mL-7000 μg/mL	0.03 μg/mL
Goat Albumin (Alb)ELISA Kit	CSB-E15758G	ALB	0.17 μg/mL-350 μg/mL	0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit	CSB-E15765Gp	ALB	0.156 μg/mL-10 μg/mL	0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit	CSB-E16204Rb	ALB	0.273 μg/mL-70 μg/mL	0.117 μg/mL
Human Angiopoietin 2,ANG-2 ELISA Kit	CSB-E04500h	ANGPT2	39 pg/mL-2500 pg/mL	9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07304r	ANGPT2	Request Information	Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07305m	ANGPT2	0.156 pg/mL-10 pg/mL	0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit	CSB-E08460p	ANGPT2	0.94 ng/mL-60 ng/mL	0.235 ng/mL
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit	CSB-EL002476HU	AXL	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit	CSB-EL002476MO	AXL	31.25 pg/ml-2000 pg/ml	7.81 pg/ml
Mouse Complement 5,C5 ELISA Kit	CSB-E13802m	C5	0.25 ng/mL-16 ng/mL	0.06 ng/mL
Rat Complement fragment 5,C5 ELISA Kit	CSB-E14363r	C5	9.38 ng/mL-600 ng/mL	2.34 ng/mL
Monkey complement C5 (C5) ELISA kit	CSB-EL003995MK	C5	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human Carbonic Anhydrase 9(CA9) ELISA Kit	CSB-E13266h	CA9	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL

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參考文獻(xiàn)：

[1] MiR21 modulates the Hippo signaling pathway via interference with PP2A Bb to inhibit trophoblast invasion and cause preeclampsia [J].Molecular Therapy: Nucleic Acids, 2022.

[2] Research progress on the STAT signaling pathway in pregnancy and pregnancy-associated disorders [J].Front Immunol,2023.

[3] Notch signalling in placental development and gestational diseases [J].Placenta,2017.

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