DLK1

DLK1，即Delta/Notch樣蛋白激酶1，別名包括Delta1、Notch1LT、ZNR4、p68、Dlk1/FA1。它是一種由DLK1基因編碼的跨膜蛋白，屬于Delta/Notch信號通路的成員，在多種組織中表達。DLK1的作用機制涉及與Notch受體的相互作用，通過非經(jīng)典Notch信號通路參與細胞命運決定和細胞增殖的調(diào)控。DLK1參與了多種生理過程，包括胚胎發(fā)育、細胞分化、組織再生和代謝調(diào)控。DLK1的功能異常與多種疾病有關，如代謝綜合征、神經(jīng)退行性疾病和癌癥。研究表明，DLK1在調(diào)節(jié)脂肪細胞分化和胰島素敏感性中發(fā)揮作用，其在腫瘤細胞中的異常表達可能與腫瘤的增殖和轉(zhuǎn)移能力增強有關。

熱銷產(chǎn)品

Recombinant Human Protein delta homolog 1 (DLK1), partial (CSB-EP006945HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DLK1 Antibody (CSB-PA006945LA01HU)

驗證數(shù)據(jù)

Western Blot
Positive WB detected in: A549 whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, SH-SY5Y whole cell lysate, Rat brain tissue
All lanes: DLK1 antibody at 4.6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42, 34 kDa
Observed band size: 42 kDa

IHC image of CSB-PA006945LA01HU diluted at 1:300 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA006945LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

DLK1 Antibody

DLK1 Protein

DLK1 ELISA Kit

DLK1 Antibodies

DLK1 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA006945GA01HU	DLK1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA006945LA01HU	DLK1 Antibody	Human, Rat	ELISA, WB, IHC, IF
CSB-PA824488	DLK1 Antibody	Human	ELISA,WB
CSB-PA120648	DLK1 Antibody	Human,Mouse	ELISA,WB

DLK1 Proteins

DLK1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP006945HU	Recombinant Human Protein delta homolog 1 (DLK1), partial	Yeast
CSB-EP006945HU	Recombinant Human Protein delta homolog 1 (DLK1), partial	E.coli
CSB-MP006945HU	Recombinant Human Protein delta homolog 1 (DLK1), partial	Mammalian cell
CSB-BP006945HU CSB-EP006945HU-B	Recombinant Human Protein delta homolog 1 (DLK1), partial	Baculovirus In Vivo Biotinylation in E.coli