IGF1R
IGF1R，即胰島素樣生長因子1受體，它是一種廣泛存在于多種組織和細(xì)胞中的跨膜受體蛋白。IGF1R由IGF1R基因編碼，是胰島素受體家族的成員之一。其作用機(jī)制涉及與胰島素樣生長因子1（IGF-1）或胰島素（Insulin）結(jié)合后，激活其內(nèi)在的酪氨酸激酶活性，進(jìn)而觸發(fā)下游的信號(hào)傳導(dǎo)途徑，包括PI3K/AKT、MAPK/ERK和JAK/STAT等。這些信號(hào)通路在細(xì)胞的增殖、分化、代謝和存活中發(fā)揮關(guān)鍵作用。在生物學(xué)意義上，IGF1R對(duì)促進(jìn)細(xì)胞生長、調(diào)節(jié)細(xì)胞周期、維持組織穩(wěn)態(tài)和促進(jìn)傷口愈合等方面具有重要作用。此外，IGF1R在胚胎發(fā)育、骨骼生長和神經(jīng)保護(hù)中也扮演著關(guān)鍵角色。然而，IGF1R的異常激活與多種癌癥的發(fā)生發(fā)展有關(guān)，包括乳腺癌、肺癌和結(jié)直腸癌等，因此它也是癌癥治療中的一個(gè)潛在靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial (CSB-EP011087HUa0)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IGF1R Recombinant Monoclonal Antibody (CSB-RA011087MA1HU)
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 008 events was performed.
Human insulin-like growth factors 1 receptor,IGF-1R ELISA Kit (CSB-E13766h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E13766h
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測(cè)范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IGF1R Antibodies
IGF1R for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011087GA01HU | IGF1R Antibody | Human,Mouse,Rat | ELISA,WB,IP |
| CSB-PA597654 | Phospho-IGF1R (Tyr1165/Tyr1166) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA067618 | IGF1R (Ab-1161) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA142373 | IGF1R (Ab-1165/1166) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA443662 | IGF1R (Ab-1280) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA449888 | Phospho-IGF1R (Tyr1280) Antibody | Human | ELISA,WB |
| CSB-PA277594 | IGF1R (Ab-1346) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA120059 | Phospho-IGF1R (Tyr1161) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA945418 | Phospho-IGF1R (Tyr1346) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA942675 | IGF1R (Ab-1346) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA000549 | Phospho-IGF1R (Y1165/Y1166) Antibody | Human,Mouse,Rat,Monkey | WB, ELISA |
| CSB-PA009487 | Phospho-IGF1R (Y1346) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA009488 | IGF1R Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA009489 | IGF1R Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA009490 | IGF1R Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA08395A0Rb | IGF1R Antibody | Human | ELISA, IF |
| CSB-PA08395B0Rb | IGF1R Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08395D0Rb | IGF1R Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA011087MA1HU | IGF1R Recombinant Monoclonal Antibody | Human | ELISA, FC |
IGF1R Proteins
IGF1R Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011087RA1 CSB-EP011087RA1 CSB-BP011087RA1 CSB-MP011087RA1 CSB-EP011087RA1-B |
Recombinant Rat Insulin-like growth factor 1 receptor (Igf1r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011087RA | Recombinant Rat Insulin-like growth factor 1 receptor (Igf1r) | in vitro E.coli expression system |
IGF1R Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011087HU | Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial | Yeast |
| CSB-EP011087HUa0 | Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial | E.coli |
| CSB-EP011087HU | Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial | E.coli |
| CSB-BP011087HU |
Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial | Baculovirus |
| CSB-EP011087HU-B | Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial,Biotinylated | E.coli |
IGF1R Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011087XBE1 CSB-EP011087XBE1 CSB-BP011087XBE1 CSB-MP011087XBE1 CSB-EP011087XBE1-B |
Recombinant Xenopus laevis Insulin-like growth factor 1 receptor (igf1r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011087XBE | Recombinant Xenopus laevis Insulin-like growth factor 1 receptor (igf1r) | in vitro E.coli expression system |
IGF1R Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011087MO CSB-EP011087MO CSB-BP011087MO CSB-MP011087MO CSB-EP011087MO-B |
Recombinant Mouse Insulin-like growth factor 1 receptor (Igf1r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IGF1R Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011087PI CSB-EP011087PI CSB-BP011087PI CSB-MP011087PI CSB-EP011087PI-B |
Recombinant Pig Insulin-like growth factor 1 receptor (IGF1R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IGF1R Proteins for Homo sapiens (Human) parvovirus B19 (isolate AU) (HPV B19)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-MP011087HU | Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial | Mammalian cell |
IGF1R ELISA Kit
IGF1R ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13766h | Human insulin-like growth factors 1 receptor,IGF-1R ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
IGF1R ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13873r | Rat Insulin-like growth factor 1 receptor, IGF-1R ELISA Kit | serum, plasma, tissue homogenates | 0.8 pg/mL |
