心血管疾病

心血管疾病是影響心臟和血管系統(tǒng)的一類疾病，包括心臟病和外周血管疾病。心臟病主要涉及心臟結(jié)構(gòu)的異常，如冠狀動(dòng)脈疾病，它是由于冠狀動(dòng)脈供血不足導(dǎo)致心肌缺血或缺氧。外周血管疾病則影響除心臟外的血管，如上肢、下肢及軀干的供血血管異常。

針對特定受體和信號通路的靶向治療是心血管疾病藥物研發(fā)的重要方向，如：

G蛋白偶聯(lián)受體（GPCR）：GPCR是一大類細(xì)胞表面受體，它們在心血管系統(tǒng)中調(diào)節(jié)多種生理過程，包括血壓和心率的控制。Apelin受體（APLNR）是GPCR家族的一員，它在心血管疾病中具有潛在的治療作用。通過設(shè)計(jì)特異性激動(dòng)劑，可以激活G蛋白信號通路，減少有害的心肌肥厚，為心力衰竭治療提供新策略。
血栓素A2受體（TP）：TP是血小板聚集和血管平滑肌細(xì)胞收縮的關(guān)鍵調(diào)節(jié)因子，是治療動(dòng)脈粥樣硬化和高血壓的潛在靶點(diǎn)。通過研究TP與其配體的結(jié)合模式，可以設(shè)計(jì)出特異性的TP抑制劑，以減少心血管疾病的發(fā)生。
離子通道：心臟和血管平滑肌細(xì)胞的離子通道在調(diào)節(jié)心臟節(jié)律和血管張力中起著核心作用。針對特定離子通道的藥物，如鈣通道阻滯劑，已經(jīng)被廣泛用于治療高血壓和心絞痛。
酶抑制劑：例如，血管緊張素轉(zhuǎn)換酶（ACE）抑制劑和血管緊張素受體阻滯劑（ARBs）通過阻斷腎素-血管緊張素系統(tǒng)來降低血壓，減少心血管疾病的風(fēng)險(xiǎn)。
脂肪酸和脂質(zhì)代謝調(diào)節(jié)劑：他汀類藥物通過抑制HMG-CoA還原酶來降低膽固醇水平，減少心血管疾病的風(fēng)險(xiǎn)。
抗凝血藥物：通過減少血液凝固來預(yù)防血栓形成，用于治療或預(yù)防中風(fēng)和心肌梗死。

心血管疾病藥物靶點(diǎn)

心血管疾病靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

TNFRSF17
CSB-MP023974HU1

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

GHR
CSB-MP009411HU

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

MS4A1 (CD20)
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL

CD47
CSB-MP004940HU

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

GPRC5D
CSB-MP882153HU

Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D at 5 μg/mL can bind Anti-GPRC5D recombinant antibody (CSB-RA882153MA01HU), the EC₅₀ is 8.847-10.38 ng/mL.

IL6
CSB-YP011664HU

Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU)，the EC₅₀ is 35.80-41.82 ng/mL.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

ANGPT2
CSB-MP001707HU(A4)

Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC₅₀ is 0.6666-0.8876 ng/mL

產(chǎn)品名稱	貨號	靶點(diǎn)	來源	蛋白標(biāo)簽
Recombinant Human Angiopoietin-2 (ANGPT2) (Active)	CSB-MP001707HU(A4)	ANGPT2	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active)	CSB-MP001707DO	ANGPT2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	CSB-AP005061HU	CD19	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active)	CSB-AP003591HU	CSF2RA	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active)	CSB-MP007479HU	EGFR	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active)	CSB-MP007763HU	ERBB2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Growth hormone receptor (GHR), partial (Active)	CSB-MP009411HU	GHR	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Growth hormone receptor (GHR), partial, Biotinylated (Active)	CSB-MP009411HUj1-B	GHR	Mammalian cell	C-terminal mFc-Avi-tagged
Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active)	CSB-MP009514HUb1	GLP1R	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human G-protein coupled receptor family C group 5 member D (GPRC5D)-VLPs (Active)	CSB-MP882153HU	GPRC5D	Mammalian cell	C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Hepatocyte growth factor (HGF) (Active)	CSB-AP003681HU	HGF	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Rhesus Macaque Interleukin-1 beta protein (IL1B) (Active)	CSB-AP003081MOW	IL1B	E.Coli	Tag-Free
Recombinant Mouse Interleukin-1 beta protein (Il1b) (Active)	CSB-AP003261MO	Il1b	E.Coli	Tag-Free
Recombinant Horse Interleukin-1 beta protein (IL1B) (Active)	CSB-AP003481HO	IL1B	E.Coli	Tag-Free

● 重組抗體

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

IGF1R Recombinant Monoclonal Antibody
CSB-RA011087MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

產(chǎn)品名稱	貨號	靶點(diǎn)	反應(yīng)種屬	應(yīng)用范圍
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA191985A0HU	ANGPT2	Human	ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA001707MA01HU	ANGPT2	Human	ELISA
C5 Recombinant Monoclonal Antibody	CSB-RA003995MA1HU	C5	Human	ELISA, FC
CD19 Recombinant Monoclonal Antibody	CSB-RA004888A0HU	CD19	Human	ELISA
CD19 Recombinant Monoclonal Antibody	CSB-RA780821A0HU	CD19	Human	ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody	CSB-RA004888MA1HU	CD19	Human, Mouse	ELISA, WB
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody	CSB-RA796695A0HU	CD38	Human	ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody	CSB-RA004931MA1HU	CD3E	Human	ELISA, FC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody	CSB-RA260392A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA1HU	ERBB2	Human	ELISA

● ELISA試劑盒

產(chǎn)品名稱	貨號	靶點(diǎn)	檢測范圍	靈敏度
Human Angiopoietin 2,ANG-2 ELISA Kit	CSB-E04500h	ANGPT2	39 pg/mL-2500 pg/mL	9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07304r	ANGPT2	Request Information	Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07305m	ANGPT2	0.156 pg/mL-10 pg/mL	0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit	CSB-E08460p	ANGPT2	0.94 ng/mL-60 ng/mL	0.235 ng/mL
Human angiopoietin-like protein 3,ANGPTL3 ELISA Kit	CSB-E11724h	ANGPTL3	78 pg/mL-5000 pg/mL	19.5 pg/mL
Mouse Angiopoietin-related protein 3(ANGPTL3) ELISA kit	CSB-EL001711MO	ANGPTL3	31.25 pg/mL-2000 pg/mL	10.24 pg/mL
Human Complement C1s subcomponent(C1S) ELISA kit	CSB-EL003657HU	C1S	25 ng/mL-1600 ng/mL	6.25 ng/mL
Mouse Complement 5,C5 ELISA Kit	CSB-E13802m	C5	0.25 ng/mL-16 ng/mL	0.06 ng/mL
Rat Complement fragment 5,C5 ELISA Kit	CSB-E14363r	C5	9.38 ng/mL-600 ng/mL	2.34 ng/mL
Monkey complement C5 (C5) ELISA kit	CSB-EL003995MK	C5	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit	CSB-E09884h	CD38	0.9 ng/mL-60 ng/mL	0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit	CSB-EL004929MO	CD38	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit	CSB-EL004936MO	CD40	Request Information	Request Information
Human Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940HU	CD47	3.12 pg/mL-200 pg/mL	0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940MO	CD47	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Human epidermal growth factor receptor,EGFR ELISA Kit	CSB-E12124h	EGFR	0.312 ng/mL-20 ng/mL	0.019 ng/mL
Human Erythropoietin receptor,EPOR ELISA Kit	CSB-E04537h	EPOR	0.156 ng/ml - 10 ng/ml	0.039 ng/ml