KDR

KDR，即Kinase Domain-containing Receptor，也被稱為血管內皮生長因子受體2。KDR是一種跨膜受體酪氨酸激酶，主要在血管內皮細胞表達，參與調控血管生成和維護血管的完整性。其作用機制涉及與VEGF家族成員如VEGFA、VEGFC和VEGFD的結合，激活后引發受體二聚化和自身酪氨酸激酶活性，進而觸發下游信號通路，如PI3K-Akt、Ras-Raf-MEK-ERK等，這些通路促進內皮細胞的增殖、遷移和血管通透性的增加。KDR在胚胎發育、組織修復、傷口愈合中發揮關鍵作用，是正常生理功能中必不可少的。同時，KDR的功能在多種病理狀態下也至關重要，尤其是在腫瘤血管生成中，其過度激活與多種腫瘤的進展、轉移密切相關，使其成為癌癥治療的重要靶點。此外，KDR還在某些心血管疾病中發揮作用，是研究和治療相關疾病的潛在靶點。

熱銷產品

Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial (Active) (CSB-MP012145HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA.Immobilized Human VEGFA(CSB-MP025833HU(F4)) at 2 μg/ml can bind Human KDR. The EC₅₀ is 11.19-12.63 ng/mL.

The purity of KDR was greater than 90% as determined by SEC-HPLC

Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial (CSB-EP012145HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KDR Antibody (CSB-PA07279A0Rb)

驗證數據

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA07279A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA07279A0Rb at dilution of 1:100

KDR Antibody

KDR Protein

KDR ELISA Kit

KDR Antibodies

KDR for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA07279A0Rb	KDR Antibody	Human	ELISA, IHC
CSB-PA07279B0Rb	KDR Antibody, HRP conjugated	Human	ELISA
CSB-PA07279C0Rb	KDR Antibody, FITC conjugated	Human
CSB-PA07279D0Rb	KDR Antibody, Biotin conjugated	Human	ELISA
CSB-PA012145GA01HU	KDR Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA898056	Phospho-KDR (Tyr1175) Antibody	Human,Mouse,Rat	ELISA,IHC,IF
CSB-PA917275	Phospho-KDR (Tyr1214) Antibody	Human,Mouse	ELISA,WB,IHC,IF
CSB-PA200726	Phospho-KDR (Tyr951) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA905984	KDR (Ab-1175) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA274392	KDR (Ab-1214) Antibody	Human,Mouse	ELISA,WB,IHC,IF
CSB-PA920878	KDR (Ab-951) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA444815	Phospho-KDR (Tyr1059) Antibody	Human,Mouse	ELISA,WB
CSB-PA070091	KDR (Ab-1059) Antibody	Human,Mouse	ELISA,WB
CSB-PA000527	Phospho-KDR (Y1175) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA000528	Phospho-KDR (Y1214) Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA002542	KDR Antibody	Human,Mouse	WB, IHC, IF, ELISA
CSB-PA002543	KDR Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA009633	Phospho-KDR (Y951) Antibody	Human,Mouse	WB, IHC, IF, ELISA
CSB-PA009634	Phospho-KDR (Y1059) Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA009638	KDR Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA009642	KDR Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA490567	KDR Antibody	Human,Mouse,Rat	IHC,ELISA
CSB-RA012145MA1HU	KDR Recombinant Monoclonal Antibody	Human	ELISA, IHC

KDR Proteins

KDR Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP012145MO CSB-EP012145MO CSB-BP012145MO CSB-MP012145MO CSB-EP012145MO-B	Recombinant Mouse Vascular endothelial growth factor receptor 2 (Kdr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KDR Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP012145HU CSB-BP012145HU CSB-EP012145HU-B	Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP012145HU	Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial	E.coli
CSB-MP012145HU	Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial (Active)	Mammalian cell
CSB-MP012145HUd7	Recombinant Human Vascular endothelial growth factor receptor 2 (KDR),partial	Mammalian cell

KDR Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP012145RA CSB-EP012145RA CSB-BP012145RA CSB-MP012145RA CSB-EP012145RA-B	Recombinant Rat Vascular endothelial growth factor receptor 2 (Kdr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KDR Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

產品貨號	產品名稱	來源
CSB-YP346773DXJ CSB-EP346773DXJ CSB-BP346773DXJ CSB-MP346773DXJ CSB-EP346773DXJ-B	Recombinant Coturnix coturnix japonica Vascular endothelial growth factor receptor 2 (KDR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KDR Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

產品貨號	產品名稱	來源
CSB-YP708034DIL CSB-EP708034DIL CSB-BP708034DIL CSB-MP708034DIL CSB-EP708034DIL-B	Recombinant Danio rerio Vascular endothelial growth factor receptor 2 (kdr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli