NECTIN4
NECTIN4，即連接蛋白細(xì)胞粘附分子4，別名LNIR、PRR4、EDSS1、PVRL4。NECTIN4蛋白是一種跨膜細(xì)胞粘附分子，屬于免疫球蛋白樣分子的Nectins家族，具有一個(gè)IGV環(huán)和兩個(gè)IGC環(huán)組成的細(xì)胞外結(jié)構(gòu)區(qū)域、跨膜結(jié)構(gòu)域以及含有afadin結(jié)合基序的細(xì)胞質(zhì)結(jié)構(gòu)域。NECTIN4通過(guò)與其他Nectins分子的相互作用參與細(xì)胞間粘附，在相鄰細(xì)胞之間形成物理連接，對(duì)于實(shí)現(xiàn)細(xì)胞間通訊、遷移和其他重要的細(xì)胞過(guò)程至關(guān)重要。
NECTIN4在多種腫瘤中過(guò)表達(dá)，如尿路上皮癌、乳腺癌、胰腺癌等，而在正常組織中的表達(dá)較低。NECTIN4的過(guò)表達(dá)與腫瘤細(xì)胞的增殖、分化、遷移、侵襲等過(guò)程相關(guān)，主要通過(guò)激活PI3K/Akt途徑促進(jìn)腫瘤細(xì)胞的增殖和遷移，是腫瘤治療的潛在靶點(diǎn)，特別是抗體藥物偶聯(lián)物（ADC）治療策略中的重要靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human Nectin-4 (NECTIN4), partial (Active) (CSB-MP822274HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized NECTIN4 at 2 μg/ml can bind anti-NECTIN4 antibody（CSB-RA822274A0HU）（enfortumab vedotin-like）, the EC50 is 0.6029-0.7837 ng/mL.
NECTIN4 Recombinant Monoclonal Antibody (CSB-RA822274A0HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of NECTIN4 with Anti-NECTIN4 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human NECTIN4(CSB-MP822274HU) at 2 μg/mL can bind Anti-NECTIN4 recombinant antibody, the EC50 is 0.6029-0.7837 ng/mL.
NECTIN4 Antibodies
NECTIN4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA060216 | PVRL4 Antibody | Human | WB, ELISA |
| CSB-PA190585 | PVRL4 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA232987 | PVRL4 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA822274LA01HU | NECTIN4 Antibody | Human, Mouse, Rat | ELISA, WB, IF |
| CSB-PA822274LB01HU | NECTIN4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA822274LC01HU | NECTIN4 Antibody, FITC conjugated | Human | |
| CSB-PA822274LD01HU | NECTIN4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA822274A0HU | NECTIN4 Recombinant Monoclonal Antibody | Human | ELISA |
NECTIN4 Proteins
NECTIN4 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP702045XBF CSB-EP702045XBF CSB-BP702045XBF CSB-MP702045XBF CSB-EP702045XBF-B |
Recombinant Xenopus tropicalis Poliovirus receptor-related protein 4 (pvrl4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NECTIN4 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP707822BO CSB-EP707822BO CSB-BP707822BO CSB-MP707822BO CSB-EP707822BO-B |
Recombinant Bovine Poliovirus receptor-related protein 4 (PVRL4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NECTIN4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP822274HU | Recombinant Human Nectin-4 (NECTIN4), partial | Yeast |
| CSB-EP822274HU CSB-BP822274HU CSB-EP822274HU-B |
Recombinant Human Nectin-4 (NECTIN4), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP005571HU | Recombinant Human Nectin-4 (NECTIN4), partial (Active) | Mammalian cell |
| CSB-MP822274HU | Recombinant Human Nectin-4 (NECTIN4), partial (Active) | Mammalian cell |
NECTIN4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP844423MO CSB-EP844423MO CSB-BP844423MO CSB-MP844423MO CSB-EP844423MO-B |
Recombinant Mouse Poliovirus receptor-related protein 4 (Pvrl4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
