食管癌

食管癌是一種起源于食管上皮細(xì)胞的惡性腫瘤，其發(fā)病率和死亡率在全球范圍內(nèi)較高。食管癌的兩種主要類型是鱗狀細(xì)胞癌和腺癌，其中鱗狀細(xì)胞癌在亞洲較為常見，而腺癌在西方國家較為普遍。食管癌的病因可能包括吸煙、飲酒、長期胃食管反流病、巴雷特食管以及某些遺傳因素等。

食管癌的治療取決于癌癥的分期、位置和患者的整體健康狀況。早期食管癌可能通過內(nèi)鏡下治療（如內(nèi)鏡黏膜切除術(shù)或內(nèi)鏡下黏膜剝離術(shù)）來治療。對于更晚期的食管癌，常用的治療方法包括手術(shù)切除、化療、放療或這些方法的組合。

近年來，食管癌的藥物研發(fā)取得了顯著進展。免疫治療已經(jīng)成為晚期食管癌治療的新標(biāo)準(zhǔn)，特別是對于一線化療失敗的患者。免疫檢查點抑制劑，如帕博利珠單抗（Pembrolizumab）、納武利尤單抗（Nivolumab）和卡瑞利珠單抗（Camrelizumab），已經(jīng)在臨床試驗中顯示出對食管癌患者的潛在療效。此外，針對HER2陽性的食管胃交界部腺癌，曲妥珠單抗（Trastuzumab）的使用也顯示出一定的療效。

在靶向治療方面，針對腫瘤生長和血管生成的特定分子靶點的藥物也在不斷研發(fā)中。例如，針對VEGFR、EGFR和HER2的小分子酪氨酸激酶抑制劑，如阿法替尼（Afatinib）和雷格拉替尼（Regorafenib），已經(jīng)在食管癌治療中顯示出一定的療效。

食管癌藥物靶點

食管癌藥物靶點相關(guān)產(chǎn)品推薦

● 靶點蛋白

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CLDN18.2
CSB-MP005498HU(A5)

Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC₅₀ is 5.225-9.256 ng/ml.

ERBB2
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

CTLA4
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

TIGIT
CSB-MP675446HU

FACS assay shows that Human TIGIT can bind to 293F cell overexpressing human CD155

ERBB3
CSB-MP007765HU

Measured by its binding ability in a functional ELISA. Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC₅₀ is 12.32-15.74 ng/ml.

MET
CSB-MP013714HU

Measured by its binding ability in a functional ELISA. Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC₅₀ is 2.379-3.094 ng/ml.

產(chǎn)品名稱	貨號	靶點	來源	蛋白標(biāo)簽
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Macaca fascicularis Claudin (CLDN18)-VLPs (Active)	CSB-MP4304MOV	CLDN18	Mammalian cell	N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Mouse Claudin-18 (Cldn18)-VLPs (Active)	CSB-MP005498MO(F3)	Cldn18	Mammalian cell	N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	Ctla4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-MP006163HU1	CTLA4	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active)	CSB-MP007479HU	EGFR	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active)	CSB-MP007763HU	ERBB2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active)	CSB-MP007765HU	ERBB3	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active)	CSB-MP010053HU	GUCY2C	Mammalian cell	N-terminal 10xHis-tagged
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active)	CSB-MP010053HUd9	GUCY2C	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005281HU	HAVCR2	Mammalian cell	C-terminal FC-Avi-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005291HU	HAVCR2	Mammalian cell	C-terminal 6xHis-Fc-tagged
Recombinant Mouse Hepatitis A virus cellular receptor 2 homolog (Havcr2), partial (Active)	CSB-AP005341MO	Havcr2	Mammalian cell	C-terminal Fc-tagged

● 重組抗體

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU

Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

Claudin-18.2 Recombinant Monoclonal Antibody
CSB-RA005498A1HU

Untransfected KATO3 cells surface (green line), transfected Human CLDN18.2 KATO3 stable cells surface (red line) and transfected.

GUCY2C Recombinant Monoclonal Antibody
CSB-RA010053A3HU

T84 cells were stained with Human IgG (green line) and anti-GUCY2C antibody (red line) (2μg/1*10⁶ cells),

產(chǎn)品名稱	貨號	靶點	反應(yīng)種屬	應(yīng)用范圍
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CLDN18 Recombinant Monoclonal Antibody	CSB-RA005498A2HU	CLDN18	Human	ELISA, FC
Claudin-18.2 Recombinant Monoclonal Antibody	CSB-RA005498A1HU	CLDN18	Human	ELISA, FC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody	CSB-RA260392A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA1HU	ERBB2	Human	ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody	CSB-RA588766A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA2HU	ERBB2	Human	ELISA, IHC
ERBB3 Recombinant Monoclonal Antibody	CSB-RA937008A0HU	ERBB3	Human	ELISA, IF
GUCY2C Recombinant Monoclonal Antibody	CSB-RA010053A3HU	GUCY2C	Human	ELISA, FC
GUCY2C Recombinant Monoclonal Antibody	CSB-RA010053A2HU	GUCY2C	Human	ELISA, FC
IL2RA Recombinant Monoclonal Antibody	CSB-RA011649MA1HU	IL2RA	Human	ELISA, IF
MET Recombinant Monoclonal Antibody	CSB-RA983271A0HU	MET	Human	ELISA, WB, IHC, IF, FC
MET Recombinant Monoclonal Antibody	CSB-RA634199A0HU	MET	Human	ELISA, IHC
MET Recombinant Monoclonal Antibody	CSB-RA013714MA1HU	MET	Human	ELISA, IF, FC
MUC17 Recombinant Monoclonal Antibody	CSB-RA727848MA1HU	MUC17	Human	ELISA
NECTIN4 Recombinant Monoclonal Antibody	CSB-RA822274A0HU	NECTIN4	Human	ELISA
PDCD1 Recombinant Monoclonal Antibody	CSB-RA240597A0HU	PDCD1	Human	ELISA, WB, IHC
TOP1 Recombinant Monoclonal Antibody	CSB-RA792129A0HU	TOP1	Human	ELISA, WB, IHC, FC, IP

● ELISA試劑盒

產(chǎn)品名稱	貨號	靶點	檢測范圍	靈敏度
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit	CSB-EL004936MO	CD40	Request Information	Request Information
Human Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940HU	CD47	3.12 pg/mL-200 pg/mL	0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940MO	CD47	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E09171h	CTLA4	125 pg/mL-8000 pg/mL	31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E13637m	CTLA4	0.312 ng/mL-20 ng/mL	0.078 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit	CSB-E12124h	EGFR	0.312 ng/mL-20 ng/mL	0.019 ng/mL
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit	CSB-E11161h	ERBB2	0.156 ng/mL-10 ng/mL	0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit	CSB-EL007765HU	ERBB3	125 pg/mL-8000 pg/mL	31.25 pg/mL
Human Hepatitis A virus cellular receptor 2(HAVCR2) ELISA kit	CSB-EL010145HU	HAVCR2	47 pg/mL-3000 pg/mL	11.75 pg/mL
Bovine Interleukin 12,IL-12 ELISA Kit	CSB-E14010B	IL12A	6.25 pg/mL-400 pg/mL	1.56 pg/mL
Human Interleukin 15,IL-15 ELISA KIT	CSB-E04603h	IL15	3.12 pg/ml - 200 pg/ml	0.78 pg/ml
Mouse Interleukin 15,IL-15 ELISA Kit	CSB-E04604m	IL15	0.3125 - 20ng/ml	0.078 ng/ml
Rat Interleukin 15,IL-15 ELISA KIT	CSB-E07453r	IL15	1.56 pg/mL-100 pg/mL	0.39 pg/mL
Pig Interleukin 15(IL-15) ELISA Kit	CSB-E14320p	IL15	0.78 pg/mL-50 pg/mL	0.195 pg/mL
Monkey Interleukin 15,IL-15 ELISA Kit	CSB-E14392Mk	IL15	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Human soluble interleukin-2 receptor,IL-2sRα ELISA kit	CSB-E04629h	IL2RA	78 pg/mL-5000 pg/mL	19.5 pg/mL
Mouse soluble interleukin-2 receptor,sIL-2Rα ELISA kit	CSB-E07440m	IL2RA	15.6 pg/ml - 1000 pg/ml	3.9 pg/ml