IFNB1

干擾素β（Interferon beta）又稱IFN-β，屬于I型干擾素家族，主要由成纖維細(xì)胞和免疫細(xì)胞分泌。該蛋白通過結(jié)合細(xì)胞表面受體，激活下游免疫應(yīng)答，抑制病毒復(fù)制并調(diào)節(jié)炎癥反應(yīng)，在抗感染和自身免疫平衡中發(fā)揮關(guān)鍵作用。其合成藥物已被廣泛應(yīng)用于多發(fā)性硬化癥治療，例如Avonex和Rebif等重組干擾素β制劑，可通過減少中樞神經(jīng)系統(tǒng)炎癥損傷延緩病情進(jìn)展。近年來，針對(duì)干擾素β的聚乙二醇化修飾技術(shù)提升了藥物穩(wěn)定性，長(zhǎng)效劑型Betaseron等進(jìn)一步改善了患者依從性。研究還發(fā)現(xiàn)，該蛋白在腫瘤免疫微環(huán)境調(diào)控中具有潛在價(jià)值，其與檢查點(diǎn)抑制劑聯(lián)用的臨床試驗(yàn)正在探索中。除神經(jīng)系統(tǒng)疾病外，干擾素β異常表達(dá)與紅斑狼瘡、干燥綜合征等自身免疫病也存在關(guān)聯(lián)，相關(guān)機(jī)制研究為開發(fā)靶向療法提供了新思路。

熱銷產(chǎn)品

Recombinant Human Interferon beta protein (IFNB1) (CSB-EP011048HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IFNB1 (dazukibart) Recombinant Monoclonal Antibody (CSB-RA011048MA1HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-RA011048MA1HU diluted at 1:300 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB.

IFNB1 Antibody

IFNB1 Protein

IFNB1 ELISA Kit

IFNB1 Antibodies

IFNB1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA06515A0Rb	IFNB1 Antibody	Human	ELISA, IHC
CSB-PA06515B0Rb	IFNB1 Antibody, HRP conjugated	Human	ELISA
CSB-PA06515D0Rb	IFNB1 Antibody, Biotin conjugated	Human	ELISA
CSB-RA011048MA1HU	IFNB1 (dazukibart) Recombinant Monoclonal Antibody	Human	ELISA, IHC

IFNB1 Proteins

IFNB1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-EP011048RA CSB-BP011048RA CSB-EP011048RA-B	Recombinant Rat Interferon beta (Ifnb1)	E.coli Baculovirus In Vivo Biotinylation in E.coli

IFNB1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP011048HU CSB-BP011048HU CSB-EP011048HU-B	Recombinant Human Interferon beta (IFNB1)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP011048HU	Recombinant Human Interferon beta protein (IFNB1)	E.coli
CSB-EP011048HUe1	Recombinant Human Interferon beta (IFNB1)	E.coli

IFNB1 Proteins for Equus caballus (Horse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP011048HO CSB-EP011048HO CSB-BP011048HO CSB-MP011048HO CSB-EP011048HO-B	Recombinant Horse Interferon beta (IFNB1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IFNB1 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP011048BO CSB-EP011048BO CSB-BP011048BO CSB-MP011048BO CSB-EP011048BO-B	Recombinant Bovine Interferon beta-1 (IFNB1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IFNB1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP011048MO CSB-EP011048MO CSB-BP011048MO CSB-EP011048MO-B	Recombinant Mouse Interferon beta (Ifnb1)	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

IFNB1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP011048MOV CSB-EP011048MOV CSB-BP011048MOV CSB-EP011048MOV-B	Recombinant Macaca fascicularis Interferon beta (IFNB1)	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

IFNB1 Proteins for Tachyglossus aculeatus aculeatus (Australian echidna)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP747707TKU CSB-EP747707TKU CSB-BP747707TKU CSB-MP747707TKU CSB-EP747707TKU-B	Recombinant Tachyglossus aculeatus aculeatus Interferon beta (IFNB1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IFNB1 Proteins for Felis catus (Cat) (Felis silvestris catus)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP863088CA CSB-EP863088CA CSB-BP863088CA CSB-MP863088CA CSB-EP863088CA-B	Recombinant Cat Interferon beta (IFNB1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli