MELTF
MELTF，全稱為melanotransferrin，別名包括MTf、MFI2、MTF1、CD228和MAP97。該蛋白是一種細(xì)胞表面糖蛋白，主要表達(dá)于黑素瘤細(xì)胞，同時(shí)也在唾液腺、腎臟等多種組織中存在。MELTF蛋白與轉(zhuǎn)鐵蛋白超家族成員具有序列相似性和鐵結(jié)合特性，但其在鐵代謝中的具體作用尚未明確。研究表明，MELTF蛋白可能參與腫瘤細(xì)胞的生長(zhǎng)和轉(zhuǎn)移過程，并可能與某些癌癥的發(fā)生發(fā)展相關(guān)。目前，針對(duì)MELTF蛋白的藥物研發(fā)尚處于早期階段，但已有研究顯示其可能成為癌癥治療的潛在靶點(diǎn)。例如，有研究探索了MELTF蛋白在黑色素瘤細(xì)胞中的表達(dá)和功能，并發(fā)現(xiàn)其可能參與腫瘤細(xì)胞的侵襲和轉(zhuǎn)移。此外，還有研究報(bào)道了MELTF蛋白在胃癌、結(jié)直腸癌等癌癥組織中的高表達(dá)，提示其可能成為癌癥診斷和治療的新的生物標(biāo)志物和治療靶點(diǎn)。未來，隨著對(duì)MELTF蛋白研究的深入，有望開發(fā)出針對(duì)該蛋白的特異性藥物，為癌癥患者提供新的治療選擇。
熱銷產(chǎn)品
Recombinant Human Melanotransferrin (MELTF) (Active) (CSB-MP013754HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human MELTF at 2 μg/ml can bind Anti-MELTF recombinant antibody (CSB-RA013754MA1HU). The EC50 is 0.3476-0.4529 ng/mL.
The purity of MELTF was greater than 95% as determined by SEC-HPLC
Recombinant Human Melanotransferrin (MELTF) (CSB-EP013754HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MELTF Antibody (CSB-PA013754LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: HEK293 whole cell lysate, Hela whole cell lysate
All lanes: MELTF antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 81, 33 kDa
Observed band size: 81 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA013754LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA013754LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Melanotransferrin(MFI2) ELISA kit (CSB-EL013754HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL013754HU
規(guī)格：96T/48T
靈敏度：0.039 ng/mL
檢測(cè)范圍：0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MELTF Antibodies
MELTF for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA013754GA01HU | MFI2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA013754LA01HU | MELTF Antibody | Human | ELISA, WB, IHC, IF |
MELTF Proteins
MELTF Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP013754HU CSB-MP013754HU CSB-EP013754HU-B |
Recombinant Human Melanotransferrin (MFI2) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP013754HU | Recombinant Human Melanotransferrin (MELTF) | E.coli |
| CSB-YP013754HU | Recombinant Human Melanotransferrin (MFI2) | Yeast |
| CSB-MP013754HU1 | Recombinant Human Melanotransferrin (MELTF) (Active) | Mammalian cell |
MELTF Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013754RB CSB-BP013754RB CSB-MP013754RB CSB-EP013754RB-B |
Recombinant Rabbit Melanotransferrin (Mfi2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP013754RB | Recombinant Rabbit Melanotransferrin (Mfi2), partial | E.coli |
MELTF Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP882604MO CSB-EP882604MO CSB-BP882604MO CSB-MP882604MO CSB-EP882604MO-B |
Recombinant Mouse Melanotransferrin (Mfi2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MELTF ELISA Kit
MELTF ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL013754HU | Human Melanotransferrin(MFI2) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.039 ng/mL |
