CTLA4

CTLA4，即細胞毒性T淋巴細胞相關蛋白4，別名CD152。CTLA4是一種主要由活化的T細胞表達的跨膜蛋白，由CTLA4基因編碼。它的作用機制是通過與B7家族分子（如CD80和CD86）結合，抑制T細胞的激活和增殖，從而調節免疫反應。CTLA4的活性在自身免疫性疾病和抗腫瘤免疫中具有重要作用，其表達水平的變化可能影響免疫耐受和免疫病理過程。CTLA4的功能異常與某些自身免疫性疾病如系統性紅斑狼瘡、類風濕關節炎等有關，同時，CTLA4也是免疫檢查點抑制劑治療的靶點之一，相關藥物如伊普利姆瑪（Ipilimumab）已用于治療黑色素瘤等癌癥。

熱銷產品

Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) (CSB-MP006163HU1)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody(CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

The purity of CTLA4 was greater than 90% as determined by SEC-HPLC.

CTLA4 Recombinant Monoclonal Antibody (CSB-RA213310A0HU)

驗證數據

IHC image of CSB-RA213310A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA213310A0HU diluted at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CTLA4 Antibody

CTLA4 Protein

CTLA4 ELISA Kit

CTLA4 Antibodies

CTLA4 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA006163KA01HU	CTLA4 Antibody	Human	ELISA,WB,IHC
CSB-PA224600	CTLA4 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA252417	CTLA4 Antibody	Human	IHC,ELISA
CSB-PA006163LA01HU	CTLA4 Antibody	Human	ELISA, IF
CSB-PA006163LB01HU	CTLA4 Antibody, HRP conjugated	Human	ELISA
CSB-RA213310A0HU	CTLA4 Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-MA006163A0m	CTLA4 Monoclonal Antibody	Human	ELISA, WB, IHC
CSB-RA006163MA1HU	CTLA4 Recombinant Monoclonal Antibody	Human	ELISA, WB, IF, FC

CTLA4 Proteins

CTLA4 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP006163HU1 CSB-BP006163HU1 CSB-MP006163HU1 CSB-EP006163HU1-B	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF006163HU	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4)	in vitro E.coli expression system
CSB-EP006163HU1	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	E.coli
CSB-AP005231HU	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	Mammalian cell
CSB-MP006163HU1	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	Mammalian cell
CSB-MP006163HU2l4	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Mammalian cell
CSB-YP006163HU2	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Yeast
CSB-YP006163HU2	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Yeast
CSB-MP006163HU2	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Mammalian cell
CSB-MP006163HU1j1-B	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial,Biotinylated	Mammalian cell
CSB-MP006163HU2d7	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Mammalian cell

CTLA4 Proteins for Oryctolagus cuniculus (Rabbit)

產品貨號	產品名稱	來源
CSB-YP006163RB1 CSB-EP006163RB1 CSB-BP006163RB1 CSB-MP006163RB1 CSB-EP006163RB1-B	Recombinant Rabbit Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF006163RB	Recombinant Rabbit Cytotoxic T-lymphocyte protein 4 (CTLA4)	in vitro E.coli expression system

CTLA4 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP006163MO1 CSB-BP006163MO1 CSB-MP006163MO1 CSB-EP006163MO1-B	Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF006163MO	Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4)	in vitro E.coli expression system
CSB-EP006163MO1	Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4),Partial	E.coli
CSB-AP005301MO	Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	Mammalian cell

CTLA4 Proteins for Sus scrofa (Pig)

產品貨號	產品名稱	來源
CSB-YP889006PI CSB-EP889006PI CSB-BP889006PI CSB-MP889006PI CSB-EP889006PI-B	Recombinant Pig Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTLA4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產品貨號	產品名稱	來源
CSB-YP894548DO CSB-EP894548DO CSB-BP894548DO CSB-MP894548DO CSB-EP894548DO-B	Recombinant Dog Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli