LAG3

LAG-3是一種具有免疫抑制功能的跨膜蛋白，其結構由胞外區(qū)的四個免疫球蛋白超家族結構域、跨膜區(qū)和胞內(nèi)區(qū)的絲氨酸磷酸化位點等關鍵元件組成。功能上，LAG-3主要通過與配體如MHC II、半乳糖凝集素-3等的相互作用，抑制T細胞的激活和細胞因子分泌，從而維持免疫穩(wěn)態(tài)。在信號通路方面，LAG-3與其配體結合后，通過胞內(nèi)結構域與下游信號分子的相互作用，調(diào)節(jié)T細胞的活化狀態(tài)。在腫瘤治療中，LAG-3作為重要靶點，通過阻斷或抑制LAG-3可增強T細胞對腫瘤的殺傷作用。因此，深入研究LAG-3的結構、功能和信號通路，對于開發(fā)新的免疫療法具有重要意義。

熱銷產(chǎn)品

Recombinant Human Lymphocyte activation gene 3 protein (LAG3), partial (Active) (CSB-MP012719HU3)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human LAG3 at 2 μg/ml can bind Anti-LAG3 recombinant antibody(CSB-RA012719MA1HU). The EC₅₀ is 2.306-2.731 ng/mL.

LAG3 Recombinant Monoclonal Antibody (CSB-RA012719MA1HU)

驗證數(shù)據(jù)

IHC image of CSB-RA012719MA1HU diluted at 1：100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

The Binding Activity of Human LAG3 with Anti-LAG3 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LAG3(CSB-MP012719HU3) at 2 μg/mL can bind Anti-LAG3 recombinant antibody. The EC₅₀ is 2.306-2.731 ng/mL.

Human Lymphocyte activation gene 3 protein(LAG3) ELISA kit (CSB-EL012719HU)

驗證數(shù)據(jù)

貨號：CSB-EL012719HU

規(guī)格：96T/48T

靈敏度：0.039 ng/mL

檢測范圍：0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

LAG3 Antibody

LAG3 Protein

LAG3 ELISA Kit

LAG3 Antibodies

LAG3 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA012719GA01HU	LAG3 Antibody	Human,Mouse	ELISA,WB
CSB-PA012719LA01HU	LAG3 Antibody	Human	ELISA, WB, IF
CSB-PA012719LC01HU	LAG3 Antibody, FITC conjugated	Human
CSB-PA012719LD01HU	LAG3 Antibody, Biotin conjugated	Human	ELISA
CSB-PA005868	LAG3 Antibody	Human	WB, ELISA
CSB-PA172061	LAG3 Antibody	Human	ELISA,WB
CSB-MA012719A0m	LAG3 Monoclonal Antibody	Human	ELISA, WB, IHC, FC
CSB-RA012719MA1HU	LAG3 Recombinant Monoclonal Antibody	Human	ELISA, IHC

LAG3 Proteins

LAG3 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP012719HU1 CSB-BP012719HU1 CSB-MP012719HU1 CSB-EP012719HU1-B	Recombinant Human Lymphocyte activation gene 3 protein (LAG3), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP012719HU1	Recombinant Human Lymphocyte activation gene 3 protein (LAG3), partial	E.coli
CSB-CF012719HU	Recombinant Human Lymphocyte activation gene 3 protein (LAG3)	in vitro E.coli expression system