TNFRSF10B
TNFRSF10B，即腫瘤壞死因子受體超家族成員10B，也稱為死亡受體5（DR5）。它是一種主要在多種組織中表達的細胞表面受體，尤其在腫瘤細胞中表達水平較高。TNFRSF10B的作用機制是通過與腫瘤壞死因子相關的凋亡誘導配體（TRAIL）結合，觸發細胞凋亡信號通路。其信號通路涉及TRAIL與TNFRSF10B結合后，死亡結構域（DD）的聚集，進而招募Fas相關死亡結構域蛋白（FADD）和啟動caspase級聯反應，特別是激活caspase-8，導致細胞程序性死亡。TNFRSF10B在調控細胞生存與死亡平衡中扮演關鍵角色，其在腫瘤細胞凋亡中的特異性作用使其成為癌癥治療的有希望的靶點，有助于開發新的靶向治療策略，以增強腫瘤細胞對凋亡的敏感性。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF10 (CSB-EP023985HU1a0) at 4 μg/ml can bind Human TNFRSF10B. The EC50 is 3.897-5.215 ng/mL.
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TNFRSF10B at 2 μg/ml can bind Anti-TNFRSF10B recombinant antibody (CSB-RA023965MA2HU). The EC50 is 1.880-2.195 ng/mL.
TNFRSF10B Antibody (CSB-PA08165A0Rb)
驗證數據
Immunofluorescence staining of HepG2 cells with CSB-PA08165A0Rb at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
TNFRSF10B Antibodies
TNFRSF10B for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA023965GA01HU | TNFRSF10B Antibody | Human | ELISA,WB |
| CSB-PA018500 | TNFRSF10B Antibody | Human | ELISA,WB |
| CSB-PA08165A0Rb | TNFRSF10B Antibody | Human | ELISA, IF |
| CSB-PA08165B0Rb | TNFRSF10B Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08165C0Rb | TNFRSF10B Antibody, FITC conjugated | Human | |
| CSB-PA08165D0Rb | TNFRSF10B Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA023965MA1HU | TNFRSF10B Recombinant Monoclonal Antibody | Human | ELISA, WB, IF |
TNFRSF10B Proteins
TNFRSF10B Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023965HU1 CSB-EP023965HU1 CSB-BP023965HU1 CSB-EP023965HU1-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP002291HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B),Partial (Active) | E.Coli |
| CSB-CF023965HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) | in vitro E.coli expression system |
| CSB-AP004921HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), partial (Active) | Mammalian cell |
| CSB-AP004931HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), partial (Active) | Mammalian cell |
TNFRSF10B Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP886404MO CSB-EP886404MO CSB-BP886404MO CSB-MP886404MO CSB-EP886404MO-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 10B (Tnfrsf10b), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP005041MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 10B (Tnfrsf10b), partial (Active) | Mammalian cell |
TNFRSF10B ELISA Kit
TNFRSF10B ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13164h | Human Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2(TRAIL-R2/DR5) ELISA Kit | serum, plasma | 7.8 pg/mL |
