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世界胰腺癌日是每年的11月第3個星期四，旨在提高公眾對胰腺癌的認識和關注。胰腺癌是一種發生在胰腺細胞中的惡性腫瘤，胰腺位于胃后方，負責分泌消化酶和調節血糖水平的激素。胰腺癌的病因尚未完全明確，但已知多個風險因素，包括吸煙、肥胖、糖尿病、慢性胰腺炎以及家族病史等。胰腺癌通常預后較差，5年存活率不足10%，早期癥狀不典型，往往在發現時已處于中晚期，因此被稱為“癌中之王”。胰腺癌的發病率在全球范圍內居惡性腫瘤的第13位，死亡率居腫瘤相關死亡的第8位。

胰腺癌主要分為兩種類型：外分泌性胰腺癌（約占所有病例的95%）和內分泌或胰島細胞瘤（也稱為胰島素細胞瘤），后者較為罕見。胰腺癌的早期癥狀不典型，可能包括上腹部不適或隱痛、消瘦、乏力等，容易被誤認為是其他消化系統疾病。因此，加強胰腺癌早期診斷和治療，對于改善胰腺癌患者的預后具有重要意義。

胰腺癌的治療手段主要包括手術切除、化療、放療、免疫和靶向治療等。免疫治療是近年來胰腺癌治療的新焦點。目前，已有多個靶向不同靶點，如IGF-lR、EGFR、HER2、VEGF、CTLA-4、PD-1的抗體藥物處于臨床研究階段 ^[1]。

為更好的協助您進行胰腺癌相關機制研究和藥物開發，華美生物特整理了胰腺癌研究相關熱門靶點及對應產品，供您參考。

胰腺癌藥物研究靶點

胰腺癌研究相關產品推薦

● 重組蛋白

CD40
CSB-MP004936HU1

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.

CLDN18.2
CSB-MP005498HU(A5)

Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC₅₀ is 5.225-9.256 ng/ml.

CTLA4
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml

MUC16
CSB-MP704410HU3c7

Measured by its binding ability in a functional ELISA. Immobilized MUC16 at 10 μg/ml can bind MSLN (CSB-MP015044HUc9), the EC₅₀ is 460.7-662.2 ng/ml.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

TACSTD2
CSB-MP023072HU2

Measured by its binding ability in a functional ELISA. Immobilized Human TROP2 at 2 μgg/mL can bind Anti-TROP2 recombinant antibody (CSB-RA023072MA1HU), the EC₅₀ is 0.9108-1.640 ng/mL.

TNFRSF9
CSB-MP023984HU1

Measured by its binding ability in a functional ELISA. Immobilized TNFRSF9 at 2 μg/ml can bind TNFSF9 (CSB-MP023997HU1), the EC₅₀ is 1.011-2.429 ng/mL.

ZG16B
CSB-MP836195HU

Measured by its binding ability in a functional ELISA. Immobilized Human ZG16B at 2 μg/ml can bind Anti-ZG16B recombinant antibody (CSB-RA836195MA1HU), the EC₅₀ is 24.13-46.04 ng/mL.

產品名稱	貨號	靶點	來源	蛋白標簽
Recombinant Human Tyrosine-protein kinase receptor UFO (AXL), partial (Active)	CSB-MP326981HUd7	AXL	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human C-C chemokine receptor type 8 (CCR8)-VLPs (Active)	CSB-MP004847HU	CCR8	Mammalian cell	C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active)	CSB-MP733578HU	CD276	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Macaca fascicularis CD276 molecule(CD276), partial (Active)	CSB-MP5140MOV	CD276	Mammalian cell	C-terminal?10xHis-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Mouse CUB domain-containing protein 1 (Cdcp1), partial (Active)	CSB-MP719456MO	Cdcp1	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human CUB domain-containing protein 1 (CDCP1), partial (Active)	CSB-MP884474HU	CDCP1	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Macaca fascicularis CUB domain containing protein 1 (CDCP1), partial (Active)	CSB-MP4569MOV	CDCP1	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Cadherin-17 (CDH17), partial (Active)	CSB-MP613267HU	CDH17	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Macaca fascicularis Cadherin 17 (CDH17), partial (Active)	CSB-MP4664MOV	CDH17	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1), partial, Biotinylated (Active)	CSB-MP005157HU-B	CEACAM1	Mammalian cell	C-terminal?10xHis-Avi-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active)	CSB-MP005165HU	CEACAM5	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Macaca mulatta Carcinoembryonic antigen-related cell adhesion molecule 5(CEACAM5), partial (Active)	CSB-MP5152MOW	CEACAM5	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) (Active)	CSB-MP005166HU	CEACAM6	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Macaca fascicularis Claudin (CLDN18)-VLPs (Active)	CSB-MP4304MOV	CLDN18	Mammalian cell	N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Mouse Claudin-18 (Cldn18)-VLPs (Active)	CSB-MP005498MO(F3)	Cldn18	Mammalian cell	N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)

● 穩定細胞株

CHOK1/Human CCR8 Stable Cell Line

CSB-SC004847HU2

Untransfected CHO-K1 cells (green line) and transfected Human CCR8 CHO-K1 stable cells (red line) were stained with anti-CCR8 antibody (CSB-RA004847A1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CT26/Human CCR8 Stable Cell Line

CSB-SC004847HU3

Untransfected CT26 cells (green line) and transfected Human CCR8 CT26 Stable cells (red line) were stained with anti-CCR8 antibody (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CHOK1/Mouse CCR8 Stable Cell Line

CSB-SC004847MO

Untransfected CHO-K1 cells (green line) and transfected Mouse CCR8 CHO-K1 Stable cells (red line) were stained with anti-Mouse CD198-PE antibody (2μg/1*10⁶ cells) and analyzed with flow cytometry.

HEK293T/Human CDH17 Stable Cell Line

CSB-SC613267HU2

Untransfected HEK293T cells (green line) and transfected Human CDH17 HEK293T stable cells (red line) were stained with anti-CDH17 antibody (CSB-RA613267MA1HU) (2μg/1*10⁶), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 抗體

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU

Tested Applications：
ELISA, WB, IF, FC

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Tested Applications：
ELISA, WB, IHC, IF, FC

GAPDH Recombinant Monoclonal Antibody
CSB-RA009232MA1HU

Tested Applications：
ELISA, WB, IHC, IF, FC

TP53 Recombinant Monoclonal Antibody
CSB-RA024077MA1HU

Tested Applications：
ELISA, WB, IF, FC

產品名稱	貨號	靶點	反應種屬	應用范圍
Phospho-AKT1 (T450) Recombinant Monoclonal Antibody	CSB-RA001553A450phHU	AKT1	Human	ELISA, WB
Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody	CSB-RA001553A473phHU	AKT1	Human	ELISA, WB, IHC, IF, IP
AKT1 Recombinant Monoclonal Antibody	CSB-RA917625A0HU	AKT1	Human, Mouse, Rat	ELISA, WB, IHC, IF
ANXA1 Recombinant Monoclonal Antibody	CSB-RA001836MA1HU	ANXA1	Human	ELISA, IHC, FC
BAG3 Recombinant Monoclonal Antibody	CSB-RA002531A0HU	BAG3	Human	ELISA, WB, IHC
CCR8 Recombinant Monoclonal Antibody	CSB-RA004847A1HU	CCR8	Human	FC
CCR8 Recombinant Monoclonal Antibody	CSB-RA004847MA3HU	CCR8	Human	FC
CCR8 Recombinant Monoclonal Antibody	CSB-RA004847MA2HU	CCR8	Human	FC
CCR8 Recombinant Monoclonal Antibody	CSB-RA004847MA4HU	CCR8	Human	FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CD8A Recombinant Monoclonal Antibody	CSB-RA934881A0HU	CD8A	Human	ELISA, WB, IHC, IP
CDCP1 Recombinant Monoclonal Antibody	CSB-RA884474MA1HU	CDCP1	Human, Mouse, Macaca fascicularis	ELISA
CDH17 Recombinant Monoclonal Antibody	CSB-RA613267MA1HU	CDH17	Human	ELISA，FC
CEACAM1 Recombinant Monoclonal Antibody	CSB-RA147192A0HU	CEACAM1	Human	ELISA, IHC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA3HU	CEACAM5	Human	ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA1HU	CEACAM5	Human	ELISA
CLDN18 Recombinant Monoclonal Antibody	CSB-RA005498A2HU	CLDN18	Human	ELISA, FC

● ELISA試劑盒

Mouse TNF-α ELISA KIT
CSB-E04741m

394篇文獻引用

Human VEGF ELISA KIT
CSB-E11718h

66篇文獻引用

Human MMP-9 ELISA Kit
CSB-E08006h

31篇文獻引用

Human NF-κB ELISA Kit
CSB-E12107h

16篇文獻引用

產品名稱	樣本類型	檢測范圍	貨號
Human RAC-alpha serine/threonine-protein kinase(AKT1) ELISA kit	serum, plasma, cell lysates	0.312 ng/mL-20 ng/mL	CSB-EL001553HU
Mouse Annexin A1(ANXA1) ELISA kit	serum, plasma, tissue homogenates	1.37ng/ml - 1000ng/ml	CSB-EL001836MO
Human Annexin Ⅰ(ANX-Ⅰ) ELISA Kit	serum, plasma, tissue homogenates	0.312 ng/mL-20 ng/mL	CSB-E12155h
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit	serum, plasma, tissue homogenates	31.25 pg/mL-2000 pg/mL	CSB-EL002476HU
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit	serum, plasma, tissue homogenates.	31.25 pg/ml-2000 pg/ml	CSB-EL002476MO
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	serum, plasma, tissue homogenates, cell lysates	15.6 pg/mL-1000 pg/mL	CSB-E13644h
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	serum, plasma, tissue homogenates	31.25 pg/mL-2000 pg/mL	CSB-EL004911MO
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit	serum, plasma, urine, cell culture supernates	3.12 ng/mL-200 ng/mL	CSB-E14285h
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit		Request Information	CSB-EL004936MO
Human Leukocyte surface antigen CD47(CD47) ELISA kit	serum, plasma, urine, tissue homogenates	3.12 pg/mL-200 pg/mL	CSB-EL004940HU
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit	serum, plasma,tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-EL004940MO
Human Cluster of differentiation 8,CD8 ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	62.5 U/mL-4000 U/mL	CSB-E12707h
Human Carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1) ELISA kit	serum, plasma, tissue homogenates	0.78 ng/mL-50 ng/mL	CSB-EL005157HU
Human carcinoembryonic antigen,CEA ELISA Kit	serum, plasma, tissue homogenates	5 ng/mL-120 ng/mL	CSB-E04767h
Mouse carcinoembryonic antign,CEA ELISA Kit	serum, plasma, tissue homogenates	62.5 pg/mL-4000 pg/mL	CSB-E13925m
Human Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6) ELISA kit	serum, plasma, tissue homogenates	0.83 ng/mL-20 ng/mL	CSB-EL005166HU
Human Macrophage Colony-Stimulating Factor Receptor,M-CSFR ELISA Kit	serum, plasma, tissue homogenates	0.156 ng/mL-10 ng/mL	CSB-E10012h
Rat Macrophage colony-stimulating factor 1 receptor(CSF1R) ELISA kit	serum, plasma, tissue homogenates	0.312 ng/mL-20 ng/mL	CSB-EL006044RA
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	serum, plasma, tissue homogenates	125 pg/mL-8000 pg/mL	CSB-E09171h
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	serum, plasma, tissue homogenates	0.312 ng/mL-20 ng/mL	CSB-E13637m