內分泌系統疾病

內分泌系統疾病是一組影響內分泌腺體正常功能的病狀，這些腺體包括但不限于甲狀腺、腎上腺、垂體和性腺等。這些疾病通常與激素分泌異常有關，可能是激素水平過高或過低，導致身體多種生理功能失衡。

常見的內分泌系統疾病包括糖尿病、甲狀腺功能異常（包括甲亢和甲減）、腎上腺疾病（如艾迪生病和庫欣綜合征）、垂體功能障礙、性腺疾病（如多囊卵巢綜合征）、骨質疏松癥和肥胖癥等。

內分泌系統疾病的藥物研針對不同疾病和病理機制，有多個靶點和治療策略。以下是一些主要疾病的藥物研發進展及其對應的靶點：

糖尿病： 糖尿病藥物研發主要靶點包括胰島素分泌、胰島素抵抗、GLP-1受體、SGLT2等，現已開發了GLP-1受體激動劑（如利拉魯肽），SGLT2抑制劑（如達格列凈），以及新型胰島素類似物，這些藥物通過不同機制降低血糖水平。
甲狀腺疾病：甲狀腺疾病藥物研發主要靶點包括甲狀腺激素合成、甲狀腺激素受體、TSH受體等。目前甲亢的治療中，已采用β-阻滯劑（如普萘洛爾）和抗甲狀腺藥物（如甲巰咪唑）。甲減的治療則依賴于甲狀腺激素替代療法。
庫欣綜合征：庫欣綜合征藥物研發主要靶向皮質醇合成和皮質醇受體。治療可能包括使用皮質醇合成抑制劑（如酮康唑）和皮質醇受體拮抗劑（如米非司酮）。
生長激素異常：生長激素異常藥物研發主要靶向生長激素分泌和生長激素受體。生長激素缺乏癥的治療使用重組人生長激素，而肢端肥大癥可能使用生長激素受體拮抗劑（如培維索孟）。
肥胖癥：生長激素異常藥物研發主要針對食欲控制、能量消耗、脂肪吸收。新型藥物（如塞美拉肽）通過模擬GLP-1的作用減少饑餓感和食物攝入。

內分泌系統疾病藥物靶點

內分泌系統疾病靶點相關產品推薦

● 靶點蛋白

GLP1R
CSB-MP009514HUb1

Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC₅₀ is 54.54-94.23 ng/mL.

GHR
CSB-MP009411HU

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CLDN18.2
CSB-MP005498HU(A5)

Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC₅₀ is 5.225-9.256 ng/ml.

EGFR
CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

GCGR
CSB-MP009316HU1

Measured by its binding ability in a functional ELISA. Immobilized human GCGR at 2 μg/ml can bind Anti-GCGR recombinant antibody (CSB-RA009316A1HU), the EC₅₀ is 3.747-6.666 ng/mL.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

ERBB2
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.

產品名稱	貨號	靶點	來源	蛋白標簽
Recombinant Human ATP-binding cassette sub-family D member 1 (ABCD1) (Active)	CSB-CF001068HU	ABCD1	in vitro E.coli expression system	C-terminal 10xHis-tagged
Recombinant Human Angiopoietin-2 (ANGPT2) (Active)	CSB-MP001707HU(A4)	ANGPT2	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active)	CSB-MP001707DO	ANGPT2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active)	CSB-MP733578HU	CD276	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-AP005191HU	CD40LG	E.coli	Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-MP004937HU3	CD40LG	Mammalian cell	N-terminal hFc-Flag-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Cadherin-17 (CDH17), partial (Active)	CSB-MP613267HU	CDH17	Mammalian cell	C-terminal?10xHis-tagged
Recombinant Macaca fascicularis Cadherin 17 (CDH17), partial (Active)	CSB-MP4664MOV	CDH17	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active)	CSB-MP005165HU	CEACAM5	Mammalian cell	C-terminal?10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) (Active)	CSB-MP005166HU	CEACAM6	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Macaca fascicularis Claudin (CLDN18)-VLPs (Active)	CSB-MP4304MOV	CLDN18	Mammalian cell	N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Mouse Claudin-18 (Cldn18)-VLPs (Active)	CSB-MP005498MO(F3)	Cldn18	Mammalian cell	N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Claudin-6 (CLDN6)-VLPs (Active)	CSB-MP005508HU(A4)	CLDN6	Mammalian cell	C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active)	CSB-MP005508HU(A4)f4	CLDN6	Mammalian cell	C-terminal GFP-tagged (This tag can be tested only under denaturing conditions)

● 穩定細胞株

HEK293T/Human CLDN6 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

HEK293T/Human CDH17 Stable Cell Line

CSB-SC613267HU2

Untransfected HEK293T cells (green line) and transfected Human CDH17 HEK293T stable cells (red line) were stained with anti-CDH17 antibody (CSB-RA613267MA1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

CLDN18 Recombinant Monoclonal Antibody
CSB-RA005498A2HU

Untransfected KATO3 cells surface (green line), transfected Human CLDN18.2 KATO3 stable cells surface (red line) and transfected Human CLDN18.1 NIH-3T3 stable cells surface (blue line) were stained with anti-CLDN18.2 antibody (2μg/1*10⁶ cells).

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

IGF1R Recombinant Monoclonal Antibody
CSB-RA011087MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.

產品名稱	貨號	靶點	反應種屬	應用范圍
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA191985A0HU	ANGPT2	Human	ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA001707MA01HU	ANGPT2	Human	ELISA
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CDH17 Recombinant Monoclonal Antibody	CSB-RA613267MA1HU	CDH17	Human	ELISA，FC
CDH6 Recombinant Monoclonal Antibody	CSB-RA005055MA1HU	CDH6	Human	ELISA
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA3HU	CEACAM5	Human	ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA1HU	CEACAM5	Human	ELISA
CLDN18 Recombinant Monoclonal Antibody	CSB-RA005498A2HU	CLDN18	Human	ELISA, FC
Claudin-18.2 Recombinant Monoclonal Antibody	CSB-RA005498A1HU	CLDN18	Human	ELISA, FC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC

● ELISA試劑盒

產品名稱	貨號	靶點	檢測范圍	靈敏度
Human Angiopoietin 2,ANG-2 ELISA Kit	CSB-E04500h	ANGPT2	39 pg/mL-2500 pg/mL	9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07304r	ANGPT2	Request Information	Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07305m	ANGPT2	0.156 pg/mL-10 pg/mL	0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit	CSB-E08460p	ANGPT2	0.94 ng/mL-60 ng/mL	0.235 ng/mL
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit	CSB-EL002476HU	AXL	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit	CSB-EL002476MO	AXL	31.25 pg/ml-2000 pg/ml	7.81 pg/ml
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit	CSB-E14285h	CD276	3.12 ng/mL-200 ng/mL	0.78 ng/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit	CSB-E09296h	CD28	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit	CSB-EL004936MO	CD40	Request Information	Request Information
Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit	CSB-E04716h	CD40LG	0.312 ng/mL-20 ng/mL	0.078 ng/mL
Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit	CSB-E04717m	CD40LG	0.274 ng/ml-200 ng/ml.	0.274 ng/ml.
Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit	CSB-E07395r	CD40LG	1.87 ng/mL-120 ng/mL	0.47 ng/mL
Human Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940HU	CD47	3.12 pg/mL-200 pg/mL	0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940MO	CD47	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Human carcinoembryonic antigen,CEA ELISA Kit	CSB-E04767h	CEACAM5	5 ng/mL-120 ng/mL	2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit	CSB-E13925m	CEACAM5	62.5 pg/mL-4000 pg/mL	15.6 pg/mL
Human Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6) ELISA kit	CSB-EL005166HU	CEACAM6	0.83 ng/mL-20 ng/mL	0.33 ng/mL