GLP1R

GLP1R，全稱為胰高血糖素樣肽-1受體，是調節血糖的重要因子。它廣泛分布于胰島β細胞、胃、小腸、心臟、腎臟、肺等組織器官中。當GLP1R被胰高血糖素樣肽-1（GLP-1）或人工合成的GLP-1R激動劑激活后，能夠促進胰島素分泌，抑制胰高血糖素分泌，減緩胃腸動力，增加飽腹感，從而發揮多種生理功能。GLP1R蛋白也被稱為GLP-1受體的別名。近年來，GLP1R受體激動劑成為治療2型糖尿病和肥胖癥的重要藥物靶點，如司美格魯肽、利拉魯肽等。目前，全球范圍內已有多種GLP-1R激動劑藥物獲批上市，為患者提供了更多的治療選擇。此外，GLP1R受體激動劑在治療非酒精性脂肪性肝炎、阿爾茨海默病等疾病方面也展現出一定的潛力。隨著對GLP1R蛋白研究的深入，其作用機制和臨床應用將得到進一步拓展。

熱銷產品

Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) (CSB-MP009514HUb1)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC₅₀ is 54.54-94.23 ng/mL.

Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial (Active) (CSB-MP009514MO1)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Glp1r at 2 μg/ml can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA3HU). The EC₅₀ is 141.7-172.4 ng/mL.

Recombinant Macaca fascicularis Glucagon-like peptide 1 receptor (GLP1R), partial (Active) (CSB-MP4826MOV)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis GLP1R at 2 μg/ml can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA2HU). The EC₅₀ is 1.292-1.518 ng/mL.

Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), patial (Active) (CSB-MP009514RA2)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Rat Glp1r at 2 μg/ml can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA2HU). The EC₅₀ is 8.630-10.66 ng/mL.

GLP1R monoclonal antibody (CSB-RA009514MA1HU)

驗證數據

The Binding Activity of GLP1R with anti-GLP1R antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R(CSB-MP009514HUb1) at 2 μg/mL can bind Anti-GLP1R recombinant antibody, the EC₅₀ is 54.54-94.23 ng/mL.

Untransfected HEK-293T cells surface (green line) and transfected Human GLP1R HEK-293T stable cells surface (red line) were stained with anti-GLP1R antibody (2μg/1*10⁶cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

Positive WB detected in: MCF-7 whole cell lysate(30μg),Mouse Heart tissue lysate(30μg),Rat Heart tissue lysate(30μg)
All lanes: GLP1R antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
Exposure time: 300s

GLP1R Antibody (CSB-PA009514YA01HU)

驗證數據

Western blot
All lanes: GLP1R antibody at 12µg/ml
Lane 1: Mouse heart tissue
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa

Immunofluorescent analysis of 293T cells using CSB-PA009514YA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

GLP1R Antibody

GLP1R Protein

GLP1R ELISA Kit

GLP1R Antibodies

GLP1R for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA009514LD01HU	GLP1R Antibody, Biotin conjugated	Human	ELISA
CSB-PA009514YA01HU	GLP1R Antibody	Human, Mouse	ELISA, WB, IF
CSB-PA009514YB01HU	GLP1R Antibody, HRP conjugated	Human	ELISA
CSB-PA009514YD01HU	GLP1R Antibody, Biotin conjugated	Human	ELISA
CSB-PA009514LA01HU	GLP1R Antibody	Human	ELISA, WB, IF
CSB-PA002699	GLP1R Antibody	Human,Mouse	WB, IF, ELISA
CSB-PA183226	GLP1R Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-RA009514MA1HU	GLP1R monoclonal antibody	Human, Mouse,Rat	ELISA, WB, FC
CSB-RA009514MA2HU	GLP1R Recombinant Monoclonal Antibody	Human, Rat, Macaca fascicularis	ELISA, IF
CSB-RA009514MA3HU	GLP1R Recombinant Monoclonal Antibody	Mouse	ELISA

GLP1R for Mus musculus (Mouse)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA009514HA01MO	Glp1r Antibody	Mouse	ELISA, WB
CSB-PA009514HB01MO	Glp1r Antibody, HRP conjugated	Mouse	ELISA
CSB-PA009514HC01MO	Glp1r Antibody, FITC conjugated	Mouse
CSB-PA009514HD01MO	Glp1r Antibody, Biotin conjugated	Mouse	ELISA

GLP1R Proteins

GLP1R Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP009514RA1	Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial	Yeast
CSB-CF009514RA	Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r)	in vitro E.coli expression system
CSB-EP009514RA1	Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial	E.coli
CSB-BP009514RA1	Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial	Baculovirus
CSB-YP009514RA	Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial	Yeast

GLP1R Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-BP009514MO1 CSB-EP009514MO1-B	Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial	Baculovirus In Vivo Biotinylation in E.coli
CSB-CF009514MO	Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r)	in vitro E.coli expression system
CSB-EP009514MO1	Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial	E.coli

GLP1R Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-EP009514HU	Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial	E.coli
CSB-YP009514HU	Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial	Yeast
CSB-MP009514HU	Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial	Mammalian cell
CSB-CF009514HU	Recombinant Human Glucagon-like peptide 1 receptor (GLP1R)	in vitro E.coli expression system
CSB-CF009514HU(A4)	Recombinant Human Glucagon-like peptide 1 receptor (GLP1R)	in vitro E.coli expression system
CSB-MP009514HU(A4)	Recombinant Human Glucagon-like peptide 1 receptor (GLP1R)-VLPs	Mammalian cell
CSB-MP009514HUb1	Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active)	Mammalian cell
CSB-EP009514HUd7	Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial	E.coli