GLP1R
GLP1R，全稱為胰高血糖素樣肽-1受體，是一種在調(diào)節(jié)血糖方面發(fā)揮重要作用的受體蛋白。該蛋白也被稱為GLP-1受體的別名。GLP1R主要分布在胰島β細胞、胃、小腸、心臟、腎臟、肺和大腦等組織器官中。當GLP1R被胰高血糖素樣肽-1（GLP-1）或人工合成的GLP-1R激動劑激活后，能夠促進胰島β細胞的增殖，刺激胰島素的合成與釋放，并抑制胰高血糖素的合成與釋放。此外，GLP1R還能抑制胃液分泌和胃腸道的蠕動，延遲胃的排空，增加飽腹感，減少食物攝取。近年來，GLP1R激動劑類藥物在治療2型糖尿病和肥胖癥方面取得了顯著成效，市場規(guī)模不斷增長。目前，全球已有多款GLP1R激動劑類藥物上市，它們不僅降糖效果顯著，同時還兼具減重、降壓、改善血脂譜等作用。未來，隨著GLP1R藥物研發(fā)的不斷深入，其在治療2型糖尿病和肥胖癥方面的應用前景將更加廣闊。
熱銷產(chǎn)品
Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) (CSB-MP009514HUb1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.
GLP1R monoclonal antibody (CSB-RA009514MA1HU)
驗證數(shù)據(jù)
The Binding Activity of GLP1R with anti-GLP1R antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R(CSB-MP009514HUb1) at 2 μg/mL can bind Anti-GLP1R recombinant antibody, the EC50 is 54.54-94.23 ng/mL.
Untransfected HEK-293T cells surface (green line) and transfected Human GLP1R HEK-293T stable cells surface (red line) were stained with anti-GLP1R antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
Positive WB detected in: MCF-7 whole cell lysate(30μg),Mouse Heart tissue lysate(30μg),Rat Heart tissue lysate(30μg)
All lanes: GLP1R antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
Exposure time: 300s
GLP1R Antibody (CSB-PA009514YA01HU)
驗證數(shù)據(jù)
Western blot
All lanes: GLP1R antibody at 12µg/ml
Lane 1: Mouse heart tissue
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
Immunofluorescent analysis of 293T cells using CSB-PA009514YA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
GLP1R Antibodies
GLP1R for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA009514LD01HU | GLP1R Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA009514YA01HU | GLP1R Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA009514YB01HU | GLP1R Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009514YD01HU | GLP1R Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA009514LA01HU | GLP1R Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA002699 | GLP1R Antibody | Human,Mouse | WB, IF, ELISA |
| CSB-PA183226 | GLP1R Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA009514MA1HU | GLP1R monoclonal antibody | Human, Mouse,Rat | ELISA, WB, FC |
| CSB-RA009514MA2HU | GLP1R Recombinant Monoclonal Antibody | Human, Rat, Macaca fascicularis | ELISA, IF |
| CSB-RA009514MA3HU | GLP1R Recombinant Monoclonal Antibody | Mouse | ELISA |
GLP1R for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA009514HA01MO | Glp1r Antibody | Mouse | ELISA, WB |
| CSB-PA009514HB01MO | Glp1r Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA009514HC01MO | Glp1r Antibody, FITC conjugated | Mouse | |
| CSB-PA009514HD01MO | Glp1r Antibody, Biotin conjugated | Mouse | ELISA |
GLP1R Proteins
GLP1R Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009514RA1 | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | Yeast |
| CSB-CF009514RA | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r) | in vitro E.coli expression system |
| CSB-EP009514RA1 | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | E.coli |
| CSB-BP009514RA1 | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | Baculovirus |
| CSB-YP009514RA | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | Yeast |
GLP1R Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP009514MO1 CSB-EP009514MO1-B |
Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF009514MO | Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r) | in vitro E.coli expression system |
| CSB-EP009514MO1 | Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial | E.coli |
GLP1R Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | E.coli |
| CSB-YP009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | Yeast |
| CSB-MP009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | Mammalian cell |
| CSB-CF009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R) | in vitro E.coli expression system |
| CSB-CF009514HU(A4) | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R) | in vitro E.coli expression system |
| CSB-MP009514HU(A4) | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R)-VLPs | Mammalian cell |
| CSB-MP009514HUb1 | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) | Mammalian cell |
| CSB-EP009514HUd7 | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | E.coli |
GLP1R Proteins for Homo sapiens(Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP009514HU | Recombinant human Glucagon-like peptide 1 receptor | Baculovirus |
GLP1R ELISA Kit
GLP1R ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL009514MO | Mouse Glucagon-like peptide 1 receptor(GLP1R) ELISA kit | serum, plasma, tissue homogenates | 0.11 ng/ml |
