TSLP
TSLP，全稱胸腺基質淋巴細胞生成素，是一種由上皮細胞等多種細胞分泌的細胞因子，在免疫調節中扮演重要角色。它主要由上皮細胞、氣道平滑肌細胞、角質形成細胞等分泌，能夠分化2型細胞中幼稚的CD4+T淋巴細胞，產生IL-4、IL-5、IL-13，并降低與1型細胞相關的γ干擾素（IFN-γ）的表達，對多種細胞產生影響。TSLP的異常表達與多種免疫相關疾病的發生和發展密切相關，如過敏性哮喘、特應性皮炎和過敏性鼻炎等過敏性疾病，以及類風濕性關節炎和系統性紅斑狼瘡等自身免疫性疾病。TSLP被證實與多種過敏性疾病有關，包括特應性皮炎、支氣管哮喘、嗜酸性粒細胞食管炎等。此外，TSLP還與慢性炎癥性疾病，如慢性阻塞性肺病和乳糜瀉，以及牛皮癬、類風濕性關節炎等自身免疫疾病有關。
TSLP靶向藥不僅具有廣譜的特點，能夠有效針對多個適應癥，而且其針對的適應癥還具備影響廣、病程長的特點，具有極高的商業價值。在適應癥上以治療哮喘居多，但是隨著深入的研究，在乳腺癌、白血病治療等方面也顯示靶點優勢。
熱銷產品
驗證數據
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
-AC1.jpg)
Activity
Loaded Cynomolgus TSLP(R127A, R130S) on 96-Flat plate, can bind anti-TSLP antibody(CSB-RA025141MA1HU), with an affinity constant of 4.41 nM as determined in BLI assay (Gator Prime).
-AC2.jpg)
Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis TSLP(R127A,R130S) at 2 μg/ml can bind Anti-TSLP recombinant antibody(CSB-RA025141MA2HU). The EC50 is 45.77-53.37 ng/mL.
Recombinant Human Thymic stromal lymphopoietin (TSLP) (R127A,R130A) (Active) (CSB-MP025141HU(M))
驗證數據
-AC1.jpg)
Activity
Measured by its binding ability in a functional ELISA. Immobilized human TSLP(R127A,R130A) at 2 μg/ml can bind Anti-TSLP recombinant antibody(CSB-RA025141MA2HU). The EC50 is 52.55-58.67 ng/mL.
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
-HPLC.jpg)
The purity of TSLP was greater than 95% as determined by SEC-HPLC
TSLP Recombinant Monoclonal Antibody (CSB-RA025141MA1HU)
驗證數據
IHC image of CSB-RA025141MA1HU diluted at 1：100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
Human thymic stromal lymphopoietin,TSLP ELISA Kit (CSB-E09316h)
驗證數據
貨號：CSB-E09316h
規格：96T/48T
靈敏度：0.078 ng/ml
檢測范圍：0.312 ng/ml-20 ng/ml
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
TSLP Antibodies
TSLP for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA025141GA01HU | TSLP Antibody | Human | ELISA,IHC |
| CSB-PA218260 | TSLP Antibody | Human | ELISA,WB |
| CSB-PA025141LA01HU | TSLP Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA025141LC01HU | TSLP Antibody, FITC conjugated | Human | |
| CSB-PA025141LD01HU | TSLP Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA025141A1HU | TSLP Monoclonal Antibody | Human | ELISA |
| CSB-RA025141MA1HU | TSLP Recombinant Monoclonal Antibody | Human | ELISA, IHC |
TSLP Proteins
TSLP Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP025141HU CSB-BP025141HU CSB-EP025141HU-B |
Recombinant Human Thymic stromal lymphopoietin (TSLP) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP002121HU | Recombinant Human Thymic stromal lymphopoietin protein (TSLP) | E.Coli |
| CSB-MP025141HU | Recombinant Human Thymic stromal lymphopoietin (TSLP) | Mammalian cell |
| CSB-EP025141HU | Recombinant Human Thymic stromal lymphopoietin (TSLP) | E.coli |
| CSB-MP025141HUh8(M) | Recombinant Human Thymic stromal lymphopoietin (TSLP)(R127A,R130A) | Mammalian cell |
| CSB-MP025141HU(M) | Recombinant Human Thymic stromal lymphopoietin (TSLP) (R127A,R130A) (Active) | Mammalian cell |
| CSB-MP025141HUh7 | Recombinant Human Thymic stromal lymphopoietin (TSLP) (Active) | Mammalian cell |
TSLP Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP025141MO CSB-EP025141MO CSB-BP025141MO CSB-MP025141MO CSB-EP025141MO-B |
Recombinant Mouse Thymic stromal lymphopoietin (Tslp) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TSLP ELISA Kit
TSLP ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09316h | Human thymic stromal lymphopoietin,TSLP ELISA Kit | serum, plasma, tissue homogenates. | 0.078 ng/ml |
TSLP ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL025141MO | Mouse Thymic stromal lymphopoietin(TSLP) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/ml |
