CDH17

CDH17，即鈣粘蛋白17，別名LI-cadherin。CDH17是一種7D-cadherin家族的成員，其胞外域由EC1-EC7七個(gè)重復(fù)序列構(gòu)成，胞內(nèi)域含18-20個(gè)氨基酸。CDH17的功能是作為多肽轉(zhuǎn)運(yùn)器和細(xì)胞粘附分子來維持上皮組織的完整性。CDH17的粘附機(jī)制與典型cadherin不同，它不需要與α和β-catenins復(fù)合，能在不與其他細(xì)胞質(zhì)成分相互作用的情況下保持粘合功能。CDH17在正常人類細(xì)胞中僅在小腸和結(jié)腸中高表達(dá)，而在肝臟、心臟和腎臟等其他組織中不表達(dá)或低表達(dá)。然而，在腫瘤組織中，CDH17在胃、胰腺、肝、食道、膽管癌和結(jié)直腸癌中過表達(dá)，其表達(dá)異常與腫瘤的形成和轉(zhuǎn)移密切相關(guān)。CDH17是消化系統(tǒng)惡性腫瘤的潛在診斷標(biāo)志物和治療靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Cadherin-17 (CDH17), partial (Active) (CSB-MP613267HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 at 2μg/mL can bind Anti-CDH17 recombinant antibody (CSB-RA613267MA1HU), the EC₅₀ is 3.095 to 4.451 ng/mL.

Recombinant Human Cadherin-1(CDH1),partial (Active) (CSB-MP005034HU1)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CDH1 at 2μg/mL can bind Anti-CDH1 recombinant antibody(CSB-RA005034MA2HU)，the EC₅₀ is 5.151-6.358 ng/mL.

Recombinant Macaca fascicularis Cadherin 17 (CDH17), partial (Active) (CSB-MP4664MOV)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CDH17 at 2 μg/ml can bind Anti-CDH17 recombinant antibody (CSB-RA613267MA3HU). The EC₅₀ is 2.182-2.529 ng/mL.

Recombinant Rat Cadherin-17 (Cdh17), partial (Active) (CSB-MP005042RA)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Rat CDH17 at 2 μg/ml can bind Anti-CDH17 recombinant antibody (CSB-RA613267MA3HU). The EC₅₀ is 13.06-14.24 ng/mL.

CDH17 Recombinant Monoclonal Antibody (CSB-RA613267MA1HU)

驗(yàn)證數(shù)據(jù)

The Binding Activity of Human CDH17 with Anti-CDH17 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 (CSB-MP613267HU) at 2 μg/mL can bind Anti-CDH17 recombinant antibody, the EC₅₀ is 3.095-4.451 ng/mL.

Untransfected HEK293T cells surface (green line) and transfected Human CDH17 HEK293T stable cells surface (red line) were stained with anti-CDH17 antibody (2μg/1*10⁶cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CDH17 Antibody

CDH17 Protein

CDH17 Antibodies

CDH17 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA613267ESR1HU	CDH17 Antibody	Human	ELISA, IHC
CSB-PA212083	CDH17 Antibody	Human	ELISA,WB,IF
CSB-PA006407	CDH17 Antibody	Human	WB, IHC, IF, ELISA
CSB-PA017530LA01HU	PCDH17 Antibody	Human	ELISA, IF
CSB-PA017530LD01HU	PCDH17 Antibody, Biotin conjugated	Human	ELISA
CSB-PA017530LC01HU	PCDH17 Antibody, FITC conjugated	Human
CSB-PA017530LB01HU	PCDH17 Antibody, HRP conjugated	Human	ELISA
CSB-RA613267MA1HU	CDH17 Recombinant Monoclonal Antibody	Human	ELISA, FC

CDH17 Proteins

CDH17 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP005042RA CSB-EP005042RA CSB-BP005042RA CSB-EP005042RA-B	Recombinant Rat Cadherin-17 (Cdh17), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

CDH17 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP017530HU CSB-EP017530HU CSB-BP017530HU CSB-MP017530HU CSB-EP017530HU-B	Recombinant Human Protocadherin-17 (PCDH17), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP613267HU CSB-BP613267HU CSB-EP613267HU-B	Recombinant Human Cadherin-17 (CDH17), partial	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP613267HU	Recombinant Human Cadherin-17 (CDH17), partial (Active)	Mammalian cell

CDH17 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-BP882608MO CSB-MP882608MO CSB-EP882608MO-B	Recombinant Mouse Cadherin-17 (Cdh17), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP882608MO	Recombinant Mouse Cadherin-17 (Cdh17), partial	E.coli
CSB-YP882608MO	Recombinant Mouse Cadherin-17 (Cdh17), partial	Yeast
CSB-MP882608MO1	Recombinant Mouse Cadherin-17 (Cdh17), partial	Mammalian cell