TYRO3
TYRO3是一種屬于TAM受體家族的受體酪氨酸激酶，它通過(guò)配體如TULP1或GAS6傳遞信號(hào)，調(diào)節(jié)細(xì)胞存活、遷移和分化等生物過(guò)程。TYRO3的結(jié)構(gòu)特征包括保守的激酶結(jié)構(gòu)域和黏附分子樣胞外域。在功能方面，TYRO3不僅參與細(xì)胞增殖、遷移和免疫抑制，還作為埃博拉病毒和馬爾堡病毒的細(xì)胞進(jìn)入因子。TYRO3通過(guò)激活下游信號(hào)通路如PI3K/Akt和調(diào)控細(xì)胞周期素D1的表達(dá)、ERK1/2或STAT3的磷酸化來(lái)發(fā)揮作用。這些信號(hào)通路的激活對(duì)于保護(hù)神經(jīng)元、調(diào)節(jié)乳腺癌細(xì)胞增殖以及參與腫瘤微環(huán)境中的免疫抑制、血管生成和腫瘤生長(zhǎng)等過(guò)程至關(guān)重要。因此，TYRO3在生物學(xué)中扮演著重要角色，為基于其結(jié)構(gòu)的靶向治療提供了新的研究方向。
熱銷產(chǎn)品
TYRO3 Antibody (CSB-PA025396LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA025396LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA025396LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA025396LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
TYRO3 Antibodies
TYRO3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025396LA01HU | TYRO3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA025396LB01HU | TYRO3 Antibody, HRP conjugated | Human | ELISA |
TYRO3 Proteins
TYRO3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP025396HU CSB-EP025396HU CSB-BP025396HU CSB-MP025396HU CSB-EP025396HU-B |
Recombinant Human Tyrosine-protein kinase receptor TYRO3 (TYRO3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TYRO3 ELISA Kit
TYRO3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL025396HU | Human Tyrosine-protein kinase receptor TYRO3(TYRO3) ELISA kit | serum, plasma,tissue homogenates | 0.11 ng/mL |
