FGFR3
FGFR3，即成纖維細胞生長因子受體3，別名FGFR3b、CD333等。FGFR3是一種跨膜受體酪氨酸激酶，屬于FGFR家族成員之一，由人體細胞自身的基因編碼。其作用機制主要是通過與成纖維細胞生長因子(FGF)結合，促使FGFR3發生二聚化和自磷酸化，進而激活下游的信號傳導途徑。FGFR3的激活可以促進細胞增殖、分化、遷移和存活，對組織再生和腫瘤發展等生物學過程具有重要影響。FGFR3在生物學上的意義非常廣泛，它參與調節多種細胞行為和生理過程。FGFR3信號通路的激活可以促進細胞周期進程，抑制細胞凋亡，從而有助于維持腫瘤細胞的生存。此外，FGFR3還與腫瘤的侵襲、轉移和血管生成等惡性行為密切相關。在腫瘤治療中，FGFR3已成為一個重要的分子靶點，針對FGFR3的抑制劑正在被開發用于治療某些類型的癌癥，如膀胱癌等。FGFR3的功能異常與多種疾病有關，包括某些遺傳性骨骼疾病和腫瘤，因此，深入研究FGFR3的生物學角色對于理解相關疾病的發病機制和開發新的治療方法具有重要意義。
熱銷產品
Recombinant Human Fibroblast growth factor receptor 3 (FGFR3 IIIc), partial (CSB-YP008646HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP008646HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) FGFR3.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP008646HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) FGFR3.
FGFR3 Recombinant Monoclonal Antibody (CSB-RA008646MA1HU)
驗證數據
Overlay Peak curve showing MCF7 cells stained with CSB-RA008646MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human Fibroblast growth factor receptor 3(FGFR3) ELISA kit (CSB-EL008646HU)
驗證數據
貨號：CSB-EL008646HU
規格：96T/48T
靈敏度：15.6 pg/mL
檢測范圍：62.5 pg/mL-4000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
FGFR3 Antibodies
FGFR3 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA008646LA01HU | FGFR3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA008646LC01HU | FGFR3 Antibody, FITC conjugated | Human | |
| CSB-PA008646LD01HU | FGFR3 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA164777 | FGFR3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA008248 | FGFR3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA114336 | FGFR3 Antibody | Human,Mouse | ELISA,IHC |
| CSB-RA555849A0HU | FGFR3 Recombinant Monoclonal Antibody | Human | ELISA, IF |
| CSB-RA966627A0HU | FGFR3 Recombinant Monoclonal Antibody | Human | ELISA, WB |
| CSB-RA008646MA1HU | FGFR3 Recombinant Monoclonal Antibody | Human | ELISA, FC |
FGFR3 Proteins
FGFR3 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008646CH1 CSB-EP008646CH1 CSB-BP008646CH1 CSB-MP008646CH1 CSB-EP008646CH1-B |
Recombinant Chicken Fibroblast growth factor receptor 3 (FGFR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008646CH | Recombinant Chicken Fibroblast growth factor receptor 3 (FGFR3) | in vitro E.coli expression system |
FGFR3 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008646HU | Recombinant Human Fibroblast growth factor receptor 3 (FGFR3 IIIc), partial | Yeast |
| CSB-EP008646HU | Recombinant Human Fibroblast growth factor receptor 3 (FGFR3 IIIc), partial | E.coli |
| CSB-YP008646HU(A4) | Recombinant Human Fibroblast growth factor receptor 3 (FGFR3 IIIc), partial | Yeast |
| CSB-BP008646HU CSB-EP008646HU-B |
Recombinant Human Fibroblast growth factor receptor 3 (FGFR3 IIIc), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP008646HU(A4) | Recombinant Human Fibroblast growth factor receptor 3 (FGFR3 IIIc), partial | E.coli |
| CSB-BP008646HU(A4) CSB-MP008646HU(A4) CSB-EP008646HU(A4)-B |
Recombinant Human Fibroblast growth factor receptor 3 (FGFR3 IIIc), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP003871HU | Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (Active) | Mammalian cell |
FGFR3 Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008646XBE CSB-EP008646XBE CSB-BP008646XBE CSB-MP008646XBE CSB-EP008646XBE-B |
Recombinant Xenopus laevis Fibroblast growth factor receptor 3 (fgfr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR3 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008646MO CSB-EP008646MO CSB-BP008646MO CSB-MP008646MO CSB-EP008646MO-B |
Recombinant Mouse Fibroblast growth factor receptor 3 (Fgfr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR3 Proteins for Pleurodeles waltl (Iberian ribbed newt)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008646EWZ CSB-EP008646EWZ CSB-BP008646EWZ CSB-MP008646EWZ CSB-EP008646EWZ-B |
Recombinant Pleurodeles waltl Fibroblast growth factor receptor 3 (FGFR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008646DIL CSB-EP008646DIL CSB-BP008646DIL CSB-MP008646DIL CSB-EP008646DIL-B |
Recombinant Danio rerio Fibroblast growth factor receptor 3 (fgfr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR3 ELISA Kit
FGFR3 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL008646HU | Human Fibroblast growth factor receptor 3(FGFR3) ELISA kit | serum, plasma, tissue homogenates | 15.6 pg/mL |
