PCSK9
PCSK9，即前蛋白轉化酶枯草桿菌蛋白酶/kexin9型，是一種肝臟合成分泌的酶，由PCSK9基因編碼。PCSK9的作用機制主要涉及調節血液中低密度脂蛋白受體（LDLR）的水平，通過與LDLR結合促進其在肝臟內降解，從而影響血液中的LDL-膽固醇水平。PCSK9對維持血脂穩態具有重要作用，其功能異常與家族性高膽固醇血癥等疾病相關。PCSK9抑制劑的開發為降低心血管疾病風險提供了新的治療策略。
熱銷產品
驗證數據
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(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Activity
Measured by its binding ability in a functional ELISA. Immobilized Anti-PCSK9 recombinant antibody (CSB-RA017647MA2HU) at 2 μg/ml can bind Human PCSK9 protein. The EC50 is 7.450-8.692 ng/mL.
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Activity
Measured by its binding ability in a functional ELISA. Immobilized Human PCSK9 at 1 μg/ml on streptavidin coated plates can bind Anti-PCSK9 recombinant antibody (CSB-RA017647MA2HU) . The EC50 is 0.3792-1.157 ng/mL.
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The purity of PCSK9 was greater than 95% as determined by SEC-HPLC
PCSK9 Recombinant Monoclonal Antibody (CSB-RA259644A0HU)
驗證數據
Western Blot
Positive WB detected in: PC-3 whole cell lysate
All lanes: PCSK9 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 75, 21 kDa
Observed band size: 60, 75 kDa
IHC image of CSB-RA259644A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Human Proprotein convertase subtilisin/kexin type 9(PCSK9) ELISA kit (CSB-EL017647HU)
驗證數據
貨號：CSB-EL017647HU
規格：96T/48T
靈敏度：0.11 ng/mL
檢測范圍：0.45 ng/mL-30 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
PCSK9 Antibodies
PCSK9 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA017647GA01HU | PCSK9 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA638311 | PCSK9 Antibody | Human | ELISA,WB |
| CSB-PA108805 | PCSK9 Antibody | Human | ELISA,WB |
| CSB-PA07039A0Rb | PCSK9 Antibody | Human | ELISA, IHC, IF |
| CSB-PA07039B0Rb | PCSK9 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA07039C0Rb | PCSK9 Antibody, FITC conjugated | Human | |
| CSB-PA07039D0Rb | PCSK9 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA017647LA01HU | PCSK9 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA017647LB01HU | PCSK9 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA017647LC01HU | PCSK9 Antibody, FITC conjugated | Human | |
| CSB-PA017647LD01HU | PCSK9 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA259644A0HU | PCSK9 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-RA017647MA1HU | PCSK9 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
PCSK9 Proteins
PCSK9 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647RA CSB-EP017647RA CSB-BP017647RA CSB-MP017647RA CSB-EP017647RA-B |
Recombinant Rat Proprotein convertase subtilisin/kexin type 9 (Pcsk9) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647MOW CSB-EP017647MOW CSB-BP017647MOW CSB-MP017647MOW CSB-EP017647MOW-B |
Recombinant Macaca mulatta (Rhesus macaque) Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Colobus guereza (Black-and-white colobus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647DVH CSB-EP017647DVH CSB-BP017647DVH CSB-MP017647DVH CSB-EP017647DVH-B |
Recombinant Colobus guereza Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Lagothrix lagotricha (Common woolly monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647LNL CSB-EP017647LNL CSB-BP017647LNL CSB-MP017647LNL CSB-EP017647LNL-B |
Recombinant Lagothrix lagotricha Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Ateles geoffroyi (Black-handed spider monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647AVF CSB-EP017647AVF CSB-BP017647AVF CSB-MP017647AVF CSB-EP017647AVF-B |
Recombinant Ateles geoffroyi Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647EQU CSB-EP017647EQU CSB-BP017647EQU CSB-MP017647EQU CSB-EP017647EQU-B |
Recombinant Pan paniscus Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647EXP CSB-EP017647EXP CSB-BP017647EXP CSB-MP017647EXP CSB-EP017647EXP-B |
Recombinant Pongo pygmaeus Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Saguinus labiatus (Red-chested mustached tamarin)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647SVY CSB-EP017647SVY CSB-BP017647SVY CSB-MP017647SVY CSB-EP017647SVY-B |
Recombinant Saguinus labiatus Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Pan troglodytes (Chimpanzee)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647EQV CSB-EP017647EQV CSB-BP017647EQV CSB-MP017647EQV CSB-EP017647EQV-B |
Recombinant Pan troglodytes Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Callicebus moloch (Dusky titi monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647CYE CSB-EP017647CYE CSB-BP017647CYE CSB-MP017647CYE CSB-EP017647CYE-B |
Recombinant Callicebus moloch Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647GGZ CSB-EP017647GGZ CSB-BP017647GGZ CSB-MP017647GGZ CSB-EP017647GGZ-B |
Recombinant Gorilla gorilla gorilla Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647CYL CSB-EP017647CYL CSB-BP017647CYL CSB-MP017647CYL CSB-EP017647CYL-B |
Recombinant Callithrix jacchus Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Macaca nemestrina (Pig-tailed macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647MOX CSB-EP017647MOX CSB-BP017647MOX CSB-MP017647MOX CSB-EP017647MOX-B |
Recombinant Macaca nemestrina Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647SWC CSB-EP017647SWC CSB-BP017647SWC CSB-MP017647SWC CSB-EP017647SWC-B |
Recombinant Saimiri boliviensis boliviensis Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647MO CSB-EP017647MO CSB-BP017647MO CSB-MP017647MO CSB-EP017647MO-B |
Recombinant Mouse Proprotein convertase subtilisin/kexin type 9 (Pcsk9) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCSK9 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017647HU CSB-EP017647HU CSB-BP017647HU CSB-MP017647HU CSB-EP017647HU-B |
Recombinant Human Proprotein convertase subtilisin/kexin type 9 (PCSK9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP005741HU | Recombinant Human Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Active) | Mammalian cell |
| CSB-MP017647HU(M) | Recombinant Human Proprotein convertase subtilisin/kexin type 9 (PCSK9) (D374Y), partial | Mammalian cell |
| CSB-MP017647HU(M1) | Recombinant Human Proprotein convertase subtilisin/kexin type 9 (PCSK9) (R194A), partial | Mammalian cell |
| CSB-MP017647HU(M)-B | Recombinant Human Proprotein convertase subtilisin/kexin type 9 (PCSK9) (D374Y), Biotinylated (Active) | Mammalian cell |
PCSK9 ELISA Kit
PCSK9 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL017647HU | Human Proprotein convertase subtilisin/kexin type 9(PCSK9) ELISA kit | serum, plasma, tissue homogenates | 0.11 ng/mL |
PCSK9 ELISA Kit for Monkey
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL017647RH | Monkey Proprotein convertase subtilisin/kexin type 9(PCSK9) ELISA kit | serum, plasma, tissue homogenates | 0.235 ng/mL |
PCSK9 ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL017647RA | Rat Proprotein convertase subtilisin/kexin type 9(PCSK9) ELISA kit | serum, plasma, tissue homogenates | 46.88 pg/mL |
