CD33
CD33又名氨基肽酶N（APN），是一種跨膜糖蛋白，屬于唾液酸結合免疫球蛋白樣凝集素的一員。CD33在交聯或者配體結合后激活，介導抑制信號，調節細胞內鈣動員、細胞粘附、白血病細胞凋亡、髓系細胞成熟和細胞因子的產生等等。CD33在90%以上的急性髓系白血病患者都有表達。在造血干細胞表面沒有表達，在成熟的粒細胞和其他組織也沒有表達，CD33作為髓系白血病治療的潛力靶點，一批企業相繼布局了CD33藥物的研發，輝瑞的靶向CD33的ADC藥物Mylotarg已獲批上市。除了ADC藥物外，靶向CD33的雙抗藥物和CAR-T細胞療法亦在如火如荼地研發中。
Recombinant Human CD33 活性蛋白實驗驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC50 of human CD33 protein is 4.289- 5.312 ng/ml.
CD33 Antibodies
CD33 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004925GA01HU | CD33 Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA004925ESR1HU | CD33 Antibody | Human | ELISA, WB, IHC |
| CSB-PA004925ESR2HU | CD33 Antibody | Human | ELISA, IHC |
| CSB-PA006175 | CD33 Antibody | Human | WB, ELISA |
| CSB-PA070366 | CD33 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA243594 | CD33 Antibody | Human | ELISA,WB,IHC |
| CSB-PA004925LA01HU | CD33 Antibody | Human | ELISA, WB, IHC |
| CSB-PA004925LD01HU | CD33 Antibody, Biotin conjugated | Human | ELISA |
CD33 Proteins
CD33 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004925HU CSB-BP004925HU CSB-EP004925HU-B |
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF004925HU(A4) | Recombinant Human Myeloid cell surface antigen CD33 (CD33) | in vitro E.coli expression system |
| CSB-MP004925HU | Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active) | Mammalian cell |
CD33 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP730931MO CSB-EP730931MO CSB-BP730931MO CSB-MP730931MO CSB-EP730931MO-B |
Recombinant Mouse Myeloid cell surface antigen CD33 (Cd33), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD33 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP004925HU | Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial | E.coli |
CD33 ELISA Kit
CD33 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL004925HU | Human Myeloid cell surface antigen CD33(CD33) ELISA kit | serum, plasma, tissue homogenates | 31.25 pg/mL |
