CD7
CD7分子是一個含有40 kDa的單鏈糖蛋白分子，屬于免疫球蛋白超家族。CD7分子是人體免疫細胞膜上一類重要的表面標志物，在淋巴細胞發育成熟過程中發揮協同刺激分子受體的作用。作為T細胞表面的高特異性靶點，CD7與大多數T細胞血液腫瘤的發生和發展息息相關，包括幼稚T細胞腫瘤（T-ALL/LBL/NKT細胞白血病）和成熟T細胞腫瘤（外周T細胞淋巴瘤、NKT細胞淋巴瘤、間變大細胞淋巴瘤）。CD7和抗體或者抗體衍生物結合后會迅速內化，這使得針對CD7分子的抗體非常適合作用藥物運輸工具。CD7分子被認為與疾病侵襲性、耐藥性及不良預后密切相關。目前，CD7分子作為靶向抗腫瘤治療的新靶點，將為CD7＋復發/難治性血液系統惡性疾病治療提供新的研究方向。
Recombinant Human CD7 活性蛋白實驗驗證數據
SDS-PAGE
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CD7 at 5 μg/ml can bind SECTM1 (CSB-MP819898HU), the EC50 is 1.236-1.773 ng/ml.
Human CD7 protein hFc and Myc tag (CSB-MP004953HU) captured on COOH chip can bind Human SECTM1 protein hFc tag (CSB-MP819898HU) with an affinity constant of 1.84 nM as detected by LSPR Assay.
CD7 Antibodies
CD7 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004953YA01HU | CD7 Antibody | Human | ELISA, IHC |
| CSB-PA004953YC01HU | CD7 Antibody, FITC conjugated | Human | |
| CSB-PA004953YD01HU | CD7 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA004953ESR1HU | CD7 Antibody | Human | ELISA, IHC |
| CSB-PA005197 | CD7 Antibody | Human | WB, ELISA |
CD7 Proteins
CD7 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004953MO1 CSB-EP004953MO1 CSB-BP004953MO1 CSB-MP004953MO1 CSB-EP004953MO1-B |
Recombinant Mouse T-cell antigen CD7 (Cd7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004953MO | Recombinant Mouse T-cell antigen CD7 (Cd7) | in vitro E.coli expression system |
CD7 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004953HU | Recombinant Human T-cell antigen CD7 (CD7), partial | Yeast |
| CSB-EP004953HU | Recombinant Human T-cell antigen CD7 (CD7), partial | E.coli |
| CSB-BP004953HU CSB-EP004953HU-B |
Recombinant Human T-cell antigen CD7 (CD7), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP004953HUb1 | Recombinant Human T-cell antigen CD7 (CD7), partial (Active) | Mammalian cell |
| CSB-MP004953HU | Recombinant Human T-cell antigen CD7 (CD7), partial (Active) | Mammalian cell |
| CSB-MP004953HU-B | Recombinant Human T-cell antigen CD7 (CD7), partial,Biotinylated | Mammalian cell |
