CD22
CD22，又被稱為Siglec-2，普遍存在于正常B細胞和B細胞惡性腫瘤中。CD22主要表達于成熟B細胞，是具有調控B細胞激活作用的細胞表面粘附分子，有助于B細胞對抗原反應敏感性的控制。此外，有研究進一步證明了CD22表達在B細胞中具有特異性，并且在小鼠和人類中都受到發育調控。CD22作為B細胞受體（BCR）的一個共受體，通過抗原引起CD22與BCR交聯，觸發CD22磷酸化，使下游信號蛋白去磷酸化和失活，從而抑制BCR信號傳導，防止自身免疫性疾病的發生。意味著，CD22表達或功能受損在自身免疫性疾病的發病機制中起重要作用，如系統性紅斑狼瘡(SLE)、類風濕性關節炎(RA)等。因此，作為限制B細胞的抗原，CD22為治療自身免疫疾病和血液癌癥中的B細胞失調提供了有效靶點。
Recombinant Human CD22 活性蛋白實驗驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.
CD22 Antibodies
CD22 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004900ESR1HU | CD22 Antibody | Human | ELISA, IHC |
| CSB-PA828492 | CD22 Antibody | Human | ELISA,WB |
| CSB-PA912726 | Phospho-CD22 (Tyr807) Antibody | Human | ELISA,WB |
| CSB-PA953915 | CD22 (Ab-807) Antibody | Human | ELISA,WB |
| CSB-PA070293 | Phospho-CD22 (Y807) Antibody | Human | WB, IHC, ELISA |
| CSB-PA070294 | CD22 Antibody | Human | WB, ELISA |
| CSB-PA616669 | CD22 Antibody | Human | ELISA,IHC |
| CSB-PA576542 | CD22 Antibody | Human | ELISA,IHC |
| CSB-RA962691A0HU | CD22 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
CD22 Proteins
CD22 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004900HU CSB-BP004900HU CSB-EP004900HU-B |
Recombinant Human B-cell receptor CD22 (CD22), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP004900HU1 | Recombinant Human B-cell receptor CD22 (CD22), partial | E.coli |
| CSB-MP004900HU | Recombinant Human B-cell receptor CD22 (CD22), partial (Active) | Mammalian cell |
| CSB-MP004900HU-B | Recombinant Human B-cell receptor CD22 (CD22), partial,Biotinylated | Mammalian cell |
CD22 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004900MO CSB-EP004900MO CSB-BP004900MO CSB-MP004900MO CSB-EP004900MO-B |
Recombinant Mouse B-cell receptor CD22 (Cd22), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD22 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP865045GGZ CSB-EP865045GGZ CSB-BP865045GGZ CSB-MP865045GGZ CSB-EP865045GGZ-B |
Recombinant Gorilla gorilla gorilla B-cell receptor CD22 (CD22) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD22 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP868228EXP CSB-EP868228EXP CSB-BP868228EXP CSB-MP868228EXP CSB-EP868228EXP-B |
Recombinant Pongo pygmaeus B-cell receptor CD22 (CD22) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD22 Proteins for Pan troglodytes (Chimpanzee)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP882013EQV CSB-EP882013EQV CSB-BP882013EQV CSB-MP882013EQV CSB-EP882013EQV-B |
Recombinant Pan troglodytes B-cell receptor CD22 (CD22) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD22 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP885632EQU CSB-EP885632EQU CSB-BP885632EQU CSB-MP885632EQU CSB-EP885632EQU-B |
Recombinant Pan paniscus B-cell receptor CD22 (CD22) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
