C5
C5，即補體成分5，別名C5α、C5b等。它是人類補體系統的一部分，由肝臟細胞產生，是一種血清蛋白。C5的作用機制主要是通過補體級聯反應被激活，C5可以被C4b2a（經典途徑和凝集素途徑）或C3bBb3b（旁路途徑）裂解為C5a和C5b兩個片段。C5a是一個具有強烈炎癥活性的小分子肽，能夠吸引和激活多種免疫細胞，如中性粒細胞和單核細胞，而C5b則啟動膜攻擊復合物（MAC）的形成，導致外來細胞的溶解。C5在生物學上的意義非常廣泛，它在天然免疫和獲得性免疫之間起著橋梁作用。C5的活化參與了清除病原體和受損細胞、調節炎癥反應、促進免疫細胞的趨化和活化等重要過程。C5a-C5aR1信號通路在多種炎癥性疾病中發揮作用，包括結直腸癌等腫瘤的發展，通過影響免疫微環境和細胞內信號傳導來促進腫瘤的發生和發展。C5的異常活化與多種自身免疫性疾病和炎癥性疾病的發生發展密切相關，因此，C5或其受體C5aR1已成為藥物開發的潛在靶點 。
熱銷產品
C5 Recombinant Monoclonal Antibody (CSB-RA003995MA1HU)
驗證數據
Overlay Peak curve showing Hela cells surface stained with CSB-RA003995MA1HU (red line) at 1:800. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 021 events was performed.
C5 Antibodies
C5 for Pig
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA003995YA01PI | C5 Antibody | Pig | ELISA, IHC |
| CSB-PA003995YD01PI | C5 Antibody, Biotin conjugated | Pig | ELISA |
| CSB-PA003995YB01PI | C5 Antibody, HRP conjugated | Pig | ELISA |
C5 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA003995LA01HU | C5 Antibody | Human | ELISA, IHC |
| CSB-PA003995LD01HU | C5 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA003995LB01HU | C5 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA003995MA1HU | C5 Recombinant Monoclonal Antibody | Human | ELISA, FC |
C5 Proteins
C5 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP003995BO CSB-EP003995BO CSB-BP003995BO CSB-MP003995BO CSB-EP003995BO-B |
Recombinant Bovine Complement C5a anaphylatoxin (C5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP003995RA CSB-BP003995RA CSB-MP003995RA CSB-EP003995RA-B |
Recombinant Rat Complement C5 (C5) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP003995RA | Recombinant Rat Complement C5 (C5) | E.coli |
C5 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP003995PI | Recombinant Pig Complement C5a anaphylatoxin (C5) | Yeast |
| CSB-EP003995PI CSB-BP003995PI CSB-MP003995PI CSB-EP003995PI-B |
Recombinant Pig Complement C5a anaphylatoxin (C5) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP003995HU CSB-BP003995HU CSB-EP003995HU-B |
Recombinant Human Complement C5 (C5), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP003995HU | Recombinant Human Complement C5 (C5), partial | Mammalian cell |
| CSB-EP003995HU | Recombinant Human Complement C5 (C5), partial | E.coli |
C5 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP003995MO CSB-EP003995MO CSB-BP003995MO CSB-MP003995MO CSB-EP003995MO-B |
Recombinant Mouse Complement C5 (C5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5 ELISA Kit
C5 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13802m | Mouse Complement 5,C5 ELISA Kit | serum, plasma, tissue homogenates | 0.06 ng/mL |
C5 ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14363r | Rat Complement fragment 5,C5 ELISA Kit | serum, plasma, tissue homogenates | 2.34 ng/mL |
