F11
F11蛋白，全稱為凝血因子XI，是一種參與血液凝固過程的血漿蛋白。它以酶原形式存在，通過二硫鍵連接形成同源二聚體。F11蛋白在凝血級聯反應中發揮著關鍵作用，能夠激活因子IX，進而觸發血液凝固的內源性途徑。F11蛋白的激活形式F11a能夠促進因子IX的活性，從而加速凝血過程。
F11蛋白的常見別名包括Factor XI concentrate、Factor XI deficiency等。F11蛋白參與多種生理和病理過程，包括血液凝固、炎癥反應和細胞凋亡等。F11蛋白的異常激活或抑制與多種疾病相關，如血栓性疾病、炎癥性疾病和腫瘤等。
目前，針對F11蛋白的藥物研發主要集中在血栓性疾病領域。例如，一些小分子抑制劑能夠抑制F11蛋白的活性，從而阻止血栓的形成。此外，一些抗體藥物能夠靶向F11蛋白，從而抑制血液凝固過程。這些藥物在治療血栓性疾病方面展現出良好的療效，并處于臨床研發的不同階段。
總之，F11蛋白是一種重要的血漿蛋白，參與血液凝固過程。F11蛋白的異常激活或抑制與多種疾病相關，針對F11蛋白的藥物研發在治療血栓性疾病方面具有重要的應用價值。
熱銷產品
Recombinant Human Coagulation factor XI (F11) (Active) (CSB-MP007916HU(A4))
驗證數據
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
-AC1.jpg)
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human F11 at 2 μg/ml can bind Anti-F11 recombinant antibody (CSB-RA007916MA1HU). The EC50 is 0.2442-0.2820 ng/mL.
-AC2.jpg)
Activity
Measured by its ability to cleave the fluorogenic peptide substrate, t-butyloxycarbonyl-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin (Boc-IEGR-AMC). The specific activity is >300 pmol/min/μg.
Recombinant Macaca mulatta Coagulation factor XI (Active) (CSB-MP5433MOW)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca mulatta F11 at 2 μg/ml can bind Anti-F11 recombinant antibody (CSB-RA007916MA1HU). The EC50 is 0.5654-0.6444 ng/mL.
Activity
Measured by its ability to cleave the fluorogenic peptide substrate, t-butyloxycarbonyl-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin (Boc-IEGR-AMC). The specific activity is >150 pmol/min/μg.
The purity of TrEMBL was greater than 95% as determined by SEC-HPLC
Recombinant Human Coagulation factor XI (F11), partial (CSB-EP007916HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
F11 (Abelacimab) Recombinant Monoclonal Antibody (CSB-RA007916MA1HU)
驗證數據
The Binding Activity of Macaca mulatta F11 with Anti-F11 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca mulatta F11 (CSB-MP5433MOW) at 2 μg/mL can bind Anti-F11 recombinant antibody. The EC50 is 0.5654-0.6444 ng/mL.
The Binding Activity of Human F11 with Anti-F11 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human F11 (CSB-MP010949HU) at 2 μg/mL can bind Anti-F11 recombinant antibody. The EC50 is 0.2442-0.2820 ng/mL.
Human Coagulation factor XI(F11) ELISA kit (CSB-EL007916HU)
驗證數據
貨號：CSB-EL007916HU
規格：96T/48T
靈敏度：19.5 pg/mL
檢測范圍：78 pg/mL-5000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
F11 Antibodies
F11 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA007916LA01HU | F11 Antibody | Human | ELISA, IHC |
| CSB-PA007916LB01HU | F11 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007916LC01HU | F11 Antibody, FITC conjugated | Human | |
| CSB-PA007916LD01HU | F11 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA007916MA1HU | F11 (Abelacimab) Recombinant Monoclonal Antibody | Human, Macaca mulatta | ELISA |
F11 Proteins
F11 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007916HU CSB-BP007916HU CSB-MP007916HU CSB-EP007916HU-B |
Recombinant Human Coagulation factor XI (F11) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP007916HU | Recombinant Human Coagulation factor XI (F11), partial | E.coli |
| CSB-MP007916HU(A4) | Recombinant Human Coagulation factor XI (F11) (Active) | Mammalian cell |
F11 Proteins for Vaccinia virus (strain L-IVP) (VACV)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP341103VAD CSB-EP341103VAD CSB-BP341103VAD CSB-MP341103VAD CSB-EP341103VAD-B |
Recombinant Vaccinia virus Protein F7 (F11) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F11 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007916MO CSB-EP007916MO CSB-BP007916MO CSB-MP007916MO CSB-EP007916MO-B |
Recombinant Mouse Coagulation factor XI (F11) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F11 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007916BO CSB-EP007916BO CSB-BP007916BO CSB-MP007916BO CSB-EP007916BO-B |
Recombinant Bovine Coagulation factor XI (F11), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F11 ELISA Kit
F11 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL007916HU | Human Coagulation factor XI(F11) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 19.5 pg/mL |
F11 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17818m | Mouse coagulation factor Ⅺ,FⅪ ELISA Kit | serum, plasma, tissue homogenates | 0.12 ng/mL |
