TFRC
TFRC，即轉(zhuǎn)鐵蛋白受體，別名CD71、TFR1、p90。TFRC由人類TFRC基因編碼，是一種II型跨膜蛋白，在細(xì)胞表面以同源二聚體的形式存在，對細(xì)胞生長至關(guān)重要。TFRC的作用機(jī)制包括與轉(zhuǎn)鐵蛋白相互作用介導(dǎo)鐵的吸收，正常生理條件下，與轉(zhuǎn)鐵蛋白結(jié)合的鐵是血液中鐵存在的主要形式。TFRC還廣泛調(diào)控與離子運輸和免疫有關(guān)的基因表達(dá)，通過影響HeLa細(xì)胞的基因表達(dá)和替代剪接參與宮頸癌的進(jìn)展，表明TFRC可能具有廣泛的調(diào)節(jié)功能。TFRC在多種腫瘤中高表達(dá)，并且與腫瘤的發(fā)生、侵襲和轉(zhuǎn)移有關(guān)，是一種重要的癌基因。TFRC的表達(dá)程度與疾病的惡性程度相關(guān)，其過表達(dá)可促進(jìn)腫瘤細(xì)胞生長、增殖和轉(zhuǎn)移，是開發(fā)抗體偶聯(lián)藥物的新靶點。
熱銷產(chǎn)品
Recombinant Human Transferrin receptor protein 1 (TFRC), partial (Active) (CSB-MP3648HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TFRC at 2μg/mL can bind Anti-TFRC recombinant antibody (CSB-RA023441MA1HU)， the EC50 is 3.305-8.220 ng/mL.
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA104885(TFRC Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA104885(TFRC Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 cells, Jurkat cells, Primary antibody: CSB-PA104885(TFRC Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
TFRC Antibodies
TFRC for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023441GA01HU | TFRC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA07219B0Rb | TFRC Antibody, HRP conjugated | Human | ELISA |
| CSB-PA07219D0Rb | TFRC Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA07219A0Rb | TFRC Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA001477 | TFRC Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA005607 | TFRC Antibody | Human | WB, ELISA |
| CSB-PA010092 | Phospho-TFRC (S24) Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA104885 | TFRC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA834425 | TFRC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-RA023441MA1HU | TFRC Recombinant Monoclonal Antibody | Human | ELISA |
TFRC Proteins
TFRC Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP651210HO CSB-EP651210HO CSB-BP651210HO CSB-MP651210HO CSB-EP651210HO-B |
Recombinant Horse Transferrin receptor protein 1 (TFRC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP719275PYX CSB-EP719275PYX CSB-BP719275PYX CSB-MP719275PYX CSB-EP719275PYX-B |
Recombinant Pongo abelii Transferrin receptor protein 1 (TFRC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP726792MO CSB-BP726792MO CSB-MP726792MO CSB-EP726792MO-B |
Recombinant Mouse Transferrin receptor protein 1 (Tfrc), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP816838PI CSB-BP816838PI CSB-MP816838PI CSB-EP816838PI-B |
Recombinant Pig Transferrin receptor protein 1 (TFRC), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP856194CH CSB-EP856194CH CSB-BP856194CH CSB-MP856194CH CSB-EP856194CH-B |
Recombinant Chicken Transferrin receptor protein 1 (TFRC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP858708RA1 CSB-BP858708RA1 CSB-MP858708RA1 CSB-EP858708RA1-B |
Recombinant Rat Transferrin receptor protein 1 (Tfrc), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP867082DO CSB-EP867082DO CSB-BP867082DO CSB-MP867082DO CSB-EP867082DO-B |
Recombinant Dog Transferrin receptor protein 1 (TFRC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP882000CA CSB-EP882000CA CSB-BP882000CA CSB-MP882000CA CSB-EP882000CA-B |
Recombinant Cat Transferrin receptor protein 1 (TFRC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Mus musculus(Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP726792MO | Recombinant Mouse Transferrin receptor protein 1 (Tfrc), partial | E.coli |
TFRC Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-MP3648HU | Recombinant Human Transferrin receptor protein 1 (TFRC), partial (Active) | Mammalian cell |
TFRC ELISA Kit
TFRC ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08389m | Mouse transferrin receptor,TFR ELISA Kit | serum, plasma, tissue homogenates | 0.156 ng/mL |
TFRC ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09100h | Human soluble transferrin receptor,sTfR ELISA Kit | serum, plasma | Request Information |
