TNFRSF17
TNFRSF17，全稱為腫瘤壞死因子受體超家族成員17，也被稱為B細胞成熟蛋白（BCMA）或CD269抗原，是腫瘤壞死因子受體（TNFR）超家族的跨膜糖蛋白成員。BCMA主要在B細胞增殖、存活以及分化為漿細胞方面發揮重要作用，并且是多發性骨髓瘤（MM）的生物標志物。BCMA具有兩種激動劑配體：增殖誘導配體（APRIL）和B細胞激活因子（BAFF）。配體與BCMA結合后，可以激活B細胞，進而促進細胞周期檢查點、抗凋亡蛋白的表達以及細胞粘附分子、血管生成因子和免疫抑制分子的產生。BCMA可作為治療多發性骨髓瘤的靶點，相關免疫療法包括CART細胞療法等已在臨床中得到應用。目前，針對BCMA的藥物研發主要集中在靶向BCMA的單克隆抗體和免疫檢查點抑制劑等方面，部分藥物已進入臨床試驗階段。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized BCMA at 2 μg/ml can bind Anti-BCMA recombinant antibody, the EC50 of human BCMA protein is 1.912-2.488 ng/ml.
Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B (CSB-MP897523HU1) at 10 μg/ml can bind human BCMA, the EC50 of human BCMA protein is 221.3-298.6 ng/ml.
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
Activity
Measured by its binding ability in a functional ELISA. Immobilized human BCMA at 5 μg/ml can bind Biotinylated human TNFSF13B (CSB-MP897523HU1-B), the EC50 is 0.1752-0.3657 ng/ml.
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TNFRSF17 Antibody (CSB-PA220479)
驗證數據
Western blot analysis of L929 293T MCF7 HELA using CD269 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
Western blot analysis of K562/JK using CD269 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
TNFRSF17 Antibodies
TNFRSF17 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA593360 | TNFRSF17 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA057490 | TNFRSF17 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA220479 | TNFRSF17 Antibody | Human | WB, ELISA |
| CSB-MA023974A0m | TNFRSF17 Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-MA023974A1m | TNFRSF17 Monoclonal Antibody | Human | ELISA, WB, IF, FC |
TNFRSF17 Proteins
TNFRSF17 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023974MO1 CSB-EP023974MO1 CSB-BP023974MO1 CSB-MP023974MO1 CSB-EP023974MO1-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 17 (Tnfrsf17), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023974MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 17 (Tnfrsf17) | in vitro E.coli expression system |
| CSB-MP023974HU | Recombinant Mouse Tumor necrosis factor receptor superfamily member 17 (Tnfrsf17), partial | Mammalian cell |
TNFRSF17 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-AP002271HU | Recombinant Human Tumor necrosis factor receptor superfamily member 17 protein (TNFRSF17), partial (Active) | E.Coli |
| CSB-MP023974HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active) | Mammalian cell |
| CSB-EP023974HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial | E.coli |
| CSB-MP023974HU1-B | Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial,Biotinylated | Mammalian cell |
| CSB-MP023974HU1h8 | Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active) | Mammalian cell |
| CSB-MP023974HU1d7 | Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active) | Mammalian cell |
TNFRSF17 ELISA Kit
TNFRSF17 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023974HU | Human Tumor necrosis factor receptor superfamily member 17(TNFRSF17) ELISA kit | serum, plasma, tissue homogenates | 1.95 pg/ml |
TNFRSF17 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023974MO | Mouse Tumor necrosis factor receptor superfamily member 17(TNFRSF17) ELISA kit | serum, plasma, tissue homogenates | 0.1 ng/ml. |
