ICAM1
ICAM1，即細(xì)胞間黏附分子1，別名包括CD54。它是一種由ICAM1基因編碼的細(xì)胞表面糖蛋白，通常在內(nèi)皮細(xì)胞和免疫系統(tǒng)的細(xì)胞上表達(dá)。ICAM1的作用機(jī)制涉及與白細(xì)胞相關(guān)抗原1（LFA-1）和巨噬細(xì)胞1（Mac-1）等整合素家族成員的相互作用，這些整合素是ICAM-1的主要受體。ICAM1在多種生物學(xué)過程中發(fā)揮作用，包括細(xì)胞黏附、信號(hào)轉(zhuǎn)導(dǎo)、免疫應(yīng)答、炎癥反應(yīng)、細(xì)胞增殖、分化、遷移和凋亡等。ICAM1參與了多種生理和病理過程的調(diào)節(jié)。ICAM1的表達(dá)在炎癥反應(yīng)中增加，促進(jìn)白細(xì)胞與內(nèi)皮細(xì)胞的黏附，有助于白細(xì)胞穿越血管壁進(jìn)入炎癥部位。此外，ICAM1在控制腫瘤惡化和轉(zhuǎn)移以及調(diào)節(jié)機(jī)體免疫反應(yīng)中也起重要作用。ICAM1通過與其受體的特異性結(jié)合，增強(qiáng)白細(xì)胞、炎癥細(xì)胞和腫瘤細(xì)胞等與內(nèi)皮細(xì)胞間的黏附作用，促進(jìn)內(nèi)皮細(xì)胞活化，使它們更容易穿透內(nèi)皮。ICAM1還參與細(xì)胞的信號(hào)轉(zhuǎn)導(dǎo)與活化、細(xì)胞組織生長(zhǎng)及分化、血管生成及腫瘤轉(zhuǎn)移等生理病理過程 。
熱銷產(chǎn)品
Recombinant Human Intercellular adhesion molecule 1 (ICAM1), partial (CSB-EP010949HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ICAM1 Recombinant Monoclonal Antibody (CSB-RA162789A0HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA162789A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA162789A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Overlay histogram showing Raji cells surface stained with CSB-RA162789A0HU (red line) at 1:50. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.
ICAM1 Antibodies
ICAM1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010949GA01HU | ICAM1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA928596 | Phospho-ICAM1 (Tyr512) Antibody | Human | ELISA,WB |
| CSB-PA918533 | ICAM1 (Ab-512) Antibody | Human | ELISA,WB |
| CSB-PA000547 | Phospho-ICAM1 (Y512) Antibody | Human | WB, ELISA |
| CSB-PA002997 | ICAM1 Antibody | Human | WB, ELISA |
| CSB-PA238929 | ICAM1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA598794 | ICAM1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA584826 | ICAM1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA793095 | ICAM1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA07149A0Rb | ICAM1 Antibody | Human, Rat | ELISA, WB, IHC, IF |
| CSB-PA07149B0Rb | ICAM1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA07149C0Rb | ICAM1 Antibody, FITC conjugated | Human | |
| CSB-PA07149D0Rb | ICAM1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-MA211660 | ICAM1 Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA162789A0HU | ICAM1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, FC |
| CSB-RA010949MA1HU | ICAM1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, FC |
ICAM1 Proteins
ICAM1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010949RA1 CSB-EP010949RA1 CSB-BP010949RA1 CSB-MP010949RA1 CSB-EP010949RA1-B |
Recombinant Rat Intercellular adhesion molecule 1 (Icam1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF010949RA | Recombinant Rat Intercellular adhesion molecule 1 (Icam1) | in vitro E.coli expression system |
ICAM1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010949MO1 CSB-EP010949MO1 CSB-BP010949MO1 CSB-MP010949MO1 CSB-EP010949MO1-B |
Recombinant Mouse Intercellular adhesion molecule 1 (Icam1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF010949MO | Recombinant Mouse Intercellular adhesion molecule 1 (Icam1) | in vitro E.coli expression system |
ICAM1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010949DO1 CSB-EP010949DO1 CSB-BP010949DO1 CSB-MP010949DO1 CSB-EP010949DO1-B |
Recombinant Dog Intercellular adhesion molecule 1 (ICAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF010949DO | Recombinant Dog Intercellular adhesion molecule 1 (ICAM1) | in vitro E.coli expression system |
ICAM1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010949HU CSB-BP010949HU CSB-EP010949HU-B |
Recombinant Human Intercellular adhesion molecule 1 (ICAM1), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP010949HU | Recombinant Human Intercellular adhesion molecule 1 (ICAM1), partial | E.coli |
| CSB-CF010949HU(A4) | Recombinant Human Intercellular adhesion molecule 1 (ICAM1) | in vitro E.coli expression system |
ICAM1 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010949EQU CSB-EP010949EQU CSB-BP010949EQU CSB-MP010949EQU CSB-EP010949EQU-B |
Recombinant Pan paniscus Intercellular adhesion molecule 1 (ICAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ICAM1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010949BO CSB-EP010949BO CSB-BP010949BO CSB-MP010949BO CSB-EP010949BO-B |
Recombinant Bovine Intercellular adhesion molecule 1 (ICAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ICAM1 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010949EQV CSB-EP010949EQV CSB-BP010949EQV CSB-MP010949EQV CSB-EP010949EQV-B |
Recombinant Pan troglodytes Intercellular adhesion molecule 1 (ICAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ICAM1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010949GGZ CSB-EP010949GGZ CSB-BP010949GGZ CSB-MP010949GGZ CSB-EP010949GGZ-B |
Recombinant Gorilla gorilla gorilla Intercellular adhesion molecule 1 (ICAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ICAM1 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010949MOW CSB-EP010949MOW CSB-BP010949MOW CSB-MP010949MOW CSB-EP010949MOW-B |
Recombinant Macaca mulatta Intercellular adhesion molecule 1 (ICAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ICAM1 ELISA Kit
ICAM1 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08898c | Dog intercellular adhesion molecule 1,ICAM-1/CD54 ELISA Kit | serum, plasma, tissue homogenates | 6.25 ng/mL |
ICAM1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04574h | Human intercellular adhesion molecule 1,ICAM-1 ELISA Kit | serum, plasma, tissue homogenates | 0.195 ng/mL |
ICAM1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04575m | Mouse intercellular adhesion molecule 1,ICAM-1 ELISA KIT | serum, plasma, tissue homogenates | 19.5 ng/mL |
ICAM1 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04576r | Rat intercellular adhesion molecule 1,ICAM-1 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 24.321 pg/mL |
