TNFRSF8
CD30又名Ki-1抗原或腫瘤壞死因子受體超家族成員8（TNFRSF8），是一種跨膜糖蛋白受體。CD30與其配體（CD30L）結合可激活TNF受體相關因子（TRAF），進而激活不同信號通路，包括TRAF2、TRAF1、TRAF5來激活核因子-κB（NFκB）等等，促進細胞增殖或凋亡。CD30還參與絲裂原激活的蛋白激酶（MAPK）通路，包括ERK1和ERK2，從而在腫瘤細胞中發揮抗凋亡和促生存作用。CD30在正常組織中表達有限，而在多種血液腫瘤呈高表達，尤其在系統性間變性大細胞淋巴瘤（sALCL）和經典型霍奇金淋巴瘤（cHL）呈高度、一致性表達。CD30的特異性表達使其具有了良好的成藥性，其中靶向CD30-ADC已經大獲成功，2011年8月，CD30-ADC--維布妥昔單抗（brentuximabvedotin）首次在美國上市，用于治療霍奇金淋巴瘤和系統性間變性大細胞淋巴瘤。基于靶向CD30細胞療法的可行性，目前已經相繼有多家制藥企業進行了CD30 CAR-T細胞藥物的研發，國內的波睿達生物、宜明細胞等均已獲得了相關發明專利授權。
Recombinant Human TNFRSF8 活性蛋白實驗驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L(CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml.
TNFRSF8 Antibodies
TNFRSF8 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA912411 | TNFRSF8 Antibody | Human | ELISA,IHC |
| CSB-PA172042 | TNFRSF8 Antibody | Human | ELISA,IHC |
TNFRSF8 Proteins
TNFRSF8 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023983RA1 CSB-EP023983RA1 CSB-BP023983RA1 CSB-MP023983RA1 CSB-EP023983RA1-B |
Recombinant Rat Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023983RA | Recombinant Rat Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8) | in vitro E.coli expression system |
TNFRSF8 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023983HU1 CSB-EP023983HU1 CSB-BP023983HU1 CSB-EP023983HU1-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF023983HU | Recombinant Human Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) | in vitro E.coli expression system |
| CSB-MP023983HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), partial (Active) | Mammalian cell |
| CSB-MP023983HU1h6 | Recombinant Human Tumor necrosis factor receptor superfamily member 8(TNFRSF8), partial | Mammalian cell |
TNFRSF8 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP723348MO CSB-EP723348MO CSB-BP723348MO CSB-MP723348MO CSB-EP723348MO-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TNFRSF8 ELISA Kit
TNFRSF8 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04525m | Mouse Cluster of differentiation 30,CD30 ELISA Kit | 3.9 pg/mL |
