TNFRSF18
TNFRSF18，即腫瘤壞死因子受體超家族成員18，也被稱為糖皮質(zhì)激素誘導的TNFR相關(guān)蛋白（GITR），是一種重要的受體分子，主要表達在參與適應性和先天免疫的細胞表面，如CD4+ T細胞、CD8+ T細胞等。在結(jié)構(gòu)上，TNFRSF18與腫瘤壞死因子受體超家族的其他成員具有相似性，作為受體，它能夠與其配體相互作用，進而觸發(fā)一系列生物學效應。在功能上，TNFRSF18主要調(diào)控T細胞的活性和功能，通過與配體的相互作用，影響T細胞的活化、增殖以及免疫應答的各個方面，同時維持免疫系統(tǒng)的平衡。在信號通路上，TNFRSF18與配體結(jié)合后，會激活一系列信號轉(zhuǎn)導過程，涉及核因子κB（NF-κB）以及特定的絲裂原活化蛋白激酶（MAPK）途徑，從而調(diào)節(jié)T細胞的活性和存活，影響免疫應答的強度和持續(xù)時間。此外，GITR與GITRL的相互作用在免疫調(diào)節(jié)中扮演重要角色，有助于增強免疫反應并具有抗腫瘤的潛在治療作用。然而，盡管我們對TNFRSF18已有一定了解，但其與配體相互作用的詳細機制及涉及的信號通路仍需進一步深入研究。未來對TNFRSF18的探究將有望為我們提供更全面的免疫系統(tǒng)認識，并為其在免疫治療中的應用提供理論支持。
熱銷產(chǎn)品
Recombinant Human Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), partial (Active)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized TNFRSF18 at 2 μg/ml can bind TNFSF18 (CSB-MP891791HU), the EC50 is 2.565 to 2.940 ng/ml.
Activity: Human TNFRSF18 protein hFc tag (CSB-MP896537HU) captured on COOH chip can bind Human TNFSF18 protein hFc and Flag tag (CSB-MP891791HU) with an affinity constant of 38.5 nM as detected by LSPR Assay.
TNFRSF18 Antibodies
TNFRSF18 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA023975LA01HU | TNFRSF18 Antibody | Human | ELISA, IHC, IF |
| CSB-PA023975LB01HU | TNFRSF18 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023975LC01HU | TNFRSF18 Antibody, FITC conjugated | Human | |
| CSB-PA023975LD01HU | TNFRSF18 Antibody, Biotin conjugated | Human | ELISA |
TNFRSF18 Proteins
TNFRSF18 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023975MO1 CSB-EP023975MO1 CSB-BP023975MO1 CSB-MP023975MO1 CSB-EP023975MO1-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 18 (Tnfrsf18), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023975MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 18 (Tnfrsf18) | in vitro E.coli expression system |
TNFRSF18 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP896537HU CSB-EP896537HU CSB-BP896537HU CSB-EP896537HU-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP896537HU | Recombinant Human Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), partial (Active) | Mammalian cell |
TNFRSF18 ELISA Kit
TNFRSF18 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023975HU | Human Tumor necrosis factor receptor superfamily member 18(TNFRSF18) ELISA kit | serum,plasma, tissue homogenates | 0.156ng/ml |
TNFRSF18 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023975MO | Mouse Tumor necrosis factor receptor superfamily member 18(TNFRSF18) ELISA kit | serum,plasma, tissue homogenates | 19.5 pg/ml |
