SLAMF7
SLAMF7，即信號淋巴細(xì)胞激活分子家族成員7。別名CD319、CS1、CRACC、19A2。它主要在免疫細(xì)胞和腫瘤細(xì)胞上表達(dá)，包括自然殺傷細(xì)胞（NK細(xì)胞）、漿細(xì)胞等。SLAMF7的作用機(jī)制包括通過其分子結(jié)構(gòu)中的胞內(nèi)區(qū)富含酪氨酸的免疫受體轉(zhuǎn)換基序（ITSMs）參與信號傳導(dǎo)，其中兩個(gè)保守酪氨酸Y281和Y261分別參與SLAMF7的激活和抑制信號通路。在腫瘤微環(huán)境中，SLAMF7可以通過調(diào)節(jié)NK細(xì)胞、單核/巨噬細(xì)胞等免疫細(xì)胞的活性，影響免疫細(xì)胞的抗腫瘤作用。例如，SLAMF7單克隆抗體——埃羅妥珠單抗（Elotuzumab）治療多發(fā)性骨髓瘤能夠誘導(dǎo)腫瘤微環(huán)境中表達(dá)SLAMF7的NK細(xì)胞、單核/巨噬細(xì)胞參與多發(fā)性骨髓瘤的抗腫瘤免疫過程。
熱銷產(chǎn)品
Recombinant Human SLAM family member 7 (SLAMF7), partial (CSB-EP021369HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SLAMF7 Recombinant Monoclonal Antibody (CSB-RA021369MA1HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA021369MA1HU diluted at 1:200 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
Overlay Peak curve showing A549 cells surface stained with CSB-RA021369MA1HU (red line) at 1:200. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,023 events was performed.
SLAMF7 Antibodies
SLAMF7 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA021369GA01HU | SLAMF7 Antibody | Human | ELISA,WB |
| CSB-PA021369ESR2HU | SLAMF7 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-RA021369MA1HU | SLAMF7 Recombinant Monoclonal Antibody | Human | ELISA, IHC, FC |
SLAMF7 Proteins
SLAMF7 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021369HU CSB-BP021369HU CSB-EP021369HU-B |
Recombinant Human SLAM family member 7 (SLAMF7), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP021369HU | Recombinant Human SLAM family member 7 (SLAMF7), partial | E.coli |
SLAMF7 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021369MO1 CSB-BP021369MO1 CSB-MP021369MO1 CSB-EP021369MO1-B |
Recombinant Mouse SLAM family member 7 (Slamf7), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP021369MO1 | Recombinant Mouse SLAM family member 7 (Slamf7), partial | E.coli |
SLAMF7 ELISA Kit
SLAMF7 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL021369HU | Human SLAM family member 7(SLAMF7) ELISA kit | serum, plasma, tissue homogenates | 19.5 pg/mL |
