CD79B
CD79B，即B細胞受體信號轉導亞單位β，別名包括Igβ、B29、CD79b等。它是一種B細胞受體(BCR)的組成部分，由CD79B基因編碼，主要在B細胞表面表達。CD79B與CD79A(Igα)形成異源二聚體，參與BCR介導的信號轉導過程，對B細胞的活化、增殖和分化具有重要作用 。CD79B的作用機制主要是通過與BCR復合物中的mIgM或mIgD結合，轉導抗原識別后的信號。當BCR識別并結合抗原后，CD79B能夠激活Src家族激酶，如Lyn，進而激活下游的Syk和Btk等酪氨酸激酶，觸發(fā)信號級聯(lián)反應。這些信號通路包括MAPK、PI3K/Akt等，最終導致細胞內鈣離子的釋放、細胞增殖和分化等生物學效應 。在生物學意義上，CD79B在B細胞發(fā)育、成熟和功能中發(fā)揮關鍵作用。它不僅參與B細胞受體介導的信號傳導，還可能參與調節(jié)B細胞的存活和凋亡。此外，CD79B在多種B細胞來源的惡性腫瘤中高度表達，如彌漫性大B細胞淋巴瘤(DLBCL)，使其成為治療某些B細胞惡性腫瘤的潛在靶點。已有針對CD79B的抗體偶聯(lián)藥物(ADC)，如Polatuzumab vedotin，被開發(fā)用于治療某些類型的非霍奇金淋巴瘤(NHL) 。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD79B at 2 μg/ml can bind Anti-CD79B recombinant antibody(CSB-RA004958MA2HU). The EC50 is 3.214-3.642 ng/mL.
CD79B Antibody (CSB-PA004958LA01HU)
驗證數(shù)據(jù)
Immunofluorescent analysis of MCF-7 cells using CSB-PA004958LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CD79B Antibodies
CD79B for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005233 | CD79B Antibody | Human | WB, IHC, ELISA |
| CSB-PA004958LA01HU | CD79B Antibody | Human | ELISA, IF |
| CSB-PA004958LB01HU | CD79B Antibody, HRP conjugated | Human | ELISA |
| CSB-RA004958MA2HU | CD79B Recombinant Monoclonal Antibody | Human | ELISA, FC |
CD79B Proteins
CD79B Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004958MO1 CSB-EP004958MO1 CSB-BP004958MO1 CSB-MP004958MO1 CSB-EP004958MO1-B |
Recombinant Mouse B-cell antigen receptor complex-associated protein beta chain (Cd79b), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004958MO | Recombinant Mouse B-cell antigen receptor complex-associated protein beta chain (Cd79b) | in vitro E.coli expression system |
CD79B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004958HU1 CSB-EP004958HU1 CSB-BP004958HU1 CSB-EP004958HU1-B |
Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF004958HU | Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B) | in vitro E.coli expression system |
| CSB-MP004958HU1 | Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B),partial (Active) | Mammalian cell |
| CSB-MP004958HU1p7 | Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B),Partial (Active) | Mammalian cell |
