MASP2
MASP2，即甘露聚糖結(jié)合凝集素相關(guān)絲氨酸蛋白酶2，它是由人體編碼的蛋白質(zhì)，屬于補(bǔ)體系統(tǒng)的一部分。MASP2主要來源于肝臟，是凝集素途徑中的關(guān)鍵效應(yīng)酶。其作用機(jī)制是在凝集素途徑激活后，MASP2被甘露糖結(jié)合凝集素（MBL）或其他模式識(shí)別分子激活，進(jìn)而裂解C4和C2，形成C3轉(zhuǎn)化酶，激活C3和C5，最終導(dǎo)致形成膜攻擊復(fù)合物（MAC），發(fā)揮溶細(xì)胞效應(yīng)。在信號(hào)通路方面，MASP2的激活是補(bǔ)體系統(tǒng)凝集素途徑的中心環(huán)節(jié)，通過其絲氨酸蛋白酶活性，MASP2參與調(diào)控免疫反應(yīng)和炎癥過程。在生物學(xué)意義上，MASP2對(duì)宿主的免疫防御至關(guān)重要，其功能異常與多種炎癥性疾病和自身免疫性疾病的發(fā)生發(fā)展相關(guān)。MASP2的活性調(diào)節(jié)為治療相關(guān)疾病提供了新的策略。
熱銷產(chǎn)品
Recombinant Human Mannan-binding lectin serine protease 2 (MASP2) (CSB-EP013510HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MASP2 Antibody (CSB-PA013510LA01HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-PA013510LA01HU diluted at 1:100 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Human mannan-binding lectin serine peptidase 2 (MASP2)ELISA kit (CSB-E17966h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E17966h
規(guī)格：96T/48T
靈敏度：5.86 pg/mL
檢測(cè)范圍：23.44 pg/mL-1500 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MASP2 Antibodies
MASP2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA943074 | MASP2 Antibody | Human | ELISA,WB |
| CSB-PA006707 | MASP2 Antibody | Human | WB, ELISA |
| CSB-PA178736 | MASP2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA159806 | MASP2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA013510LA01HU | MASP2 Antibody | Human | ELISA, IHC |
| CSB-PA013510LB01HU | MASP2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA013510LC01HU | MASP2 Antibody, FITC conjugated | Human | |
| CSB-PA013510LD01HU | MASP2 Antibody, Biotin conjugated | Human | ELISA |
MASP2 Proteins
MASP2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013510HU CSB-EP013510HU-B |
Recombinant Human Mannan-binding lectin serine protease 2 (MASP2) | Yeast In Vivo Biotinylation in E.coli |
| CSB-BP013510HU | Recombinant Human Mannan-binding lectin serine protease 2 (MASP2) | Baculovirus |
| CSB-EP013510HU | Recombinant Human Mannan-binding lectin serine protease 2 (MASP2) | E.coli |
MASP2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP856307MO CSB-EP856307MO-B |
Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2) | Yeast In Vivo Biotinylation in E.coli |
| CSB-EP856307MO | Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2) | E.coli |
| CSB-BP856307MO | Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2) | Baculovirus |
| CSB-BP856307MOc7 | Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2) | Baculovirus |
MASP2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP867502RA CSB-EP867502RA CSB-EP867502RA-B |
Recombinant Rat Mannan-binding lectin serine protease 2 (Masp2) | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP867502RA | Recombinant Rat Mannan-binding lectin serine protease 2 (Masp2) | Baculovirus |
MASP2 ELISA Kit
MASP2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17966h | Human mannan-binding lectin serine peptidase 2 (MASP2)ELISA kit | serum, plasma, cell culture supernates, cerebrospinal fluid (CSF) | 5.86 pg/mL |
MASP2 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL013510MO | Mouse Mannan-binding lectin serine protease 2(MASP2) ELISA kit | serum, plasma, tissue homogenates | 31.2 pg/mL |
