SLC3A2
SLC3A2，全稱為溶質載體家族3成員2（Solute carrier family 3 member 2），也被稱為CD98重鏈或SLC3A2/CD98，是一種位于細胞表面的跨膜蛋白。它參與多種氨基酸的跨膜運輸，特別是L型氨基酸，如精氨酸、谷氨酰胺和組氨酸。SLC3A2與輕鏈CD98形成異二聚體，共同構成功能性氨基酸轉運系統，在調節細胞內鈣水平和氨基酸代謝中發揮重要作用。
SLC3A2蛋白的表達與多種生理和病理過程相關。在正常情況下，它參與T細胞的分化和功能調節，以及腸道上皮細胞的代謝和穩態維持。然而，當SLC3A2蛋白的表達異常或功能失調時，則可能與多種疾病的發生發展密切相關，包括腫瘤、代謝性疾病和免疫疾病等。例如，研究表明SLC3A2蛋白在多種腫瘤細胞中高表達，并參與細胞的惡性轉化和腫瘤的進展。此外，SLC3A2蛋白也與一些代謝性疾病和免疫疾病相關，如賴氨酸尿蛋白不耐受和胱氨酸尿癥，以及炎癥性腸病等。
針對SLC3A2蛋白的藥物研發目前尚處于早期階段。一些研究表明，通過抑制SLC3A2蛋白的表達或功能，可以抑制腫瘤細胞的生長和轉移，并增強化療藥物的療效。此外，SLC3A2蛋白也被認為是潛在的免疫治療靶點，通過調節SLC3A2蛋白的表達或功能，可以增強T細胞的功能，并抑制腫瘤的生長和轉移。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human SLC3A2 at 2 μg/ml can bind Anti-SLC3A2 recombinant antibody (CSB-RA021640MA1HU). The EC50 is 2.257-3.091 ng/mL.
SLC3A2 Recombinant Monoclonal Antibody (CSB-RA021640MA1HU)
驗證數據
The Binding Activity of Human SLC3A2 with Anti-SLC3A2 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SLC3A2 protein (CSB-MP021640HU1) at 2 μg/mL can bind Anti-SLC3A2 recombinant antibody. The EC50 is 2.257-3.091 ng/mL.
SLC3A2 Antibody (CSB-PA006233)
驗證數據
Western Blot analysis of HEB cells using CD98 Polyclonal Antibody
SLC3A2 Antibodies
SLC3A2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA021640GA01HU | SLC3A2 Antibody | Human | ELISA,WB,IHC |
| CSB-PA006233 | SLC3A2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA021640LA01HU | SLC3A2 Antibody | Human | ELISA, WB |
| CSB-PA021640LB01HU | SLC3A2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA021640LC01HU | SLC3A2 Antibody, FITC conjugated | Human | |
| CSB-PA021640LD01HU | SLC3A2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA021640MA1HU | SLC3A2 Recombinant Monoclonal Antibody | Human | ELISA |
SLC3A2 Proteins
SLC3A2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP021640MO1 CSB-EP021640MO1 CSB-BP021640MO1 CSB-MP021640MO1 CSB-EP021640MO1-B |
Recombinant Mouse Amino acid transporter heavy chain SLC3A2 (Slc3a2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021640MO | Recombinant Mouse Amino acid transporter heavy chain SLC3A2 (Slc3a2) | in vitro E.coli expression system |
SLC3A2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP021640HU1 CSB-EP021640HU1 CSB-BP021640HU1 CSB-EP021640HU1-B |
Recombinant Human 4F2 cell-surface antigen heavy chain (SLC3A2), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF021640HU | Recombinant Human Amino acid transporter heavy chain SLC3A2 (SLC3A2) | in vitro E.coli expression system |
| CSB-MP021640HU1 | Recombinant Human Amino acid transporter heavy chain SLC3A2 (SLC3A2), partial (Active) | Mammalian cell |
SLC3A2 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP765772RA CSB-EP765772RA CSB-BP765772RA CSB-MP765772RA CSB-EP765772RA-B |
Recombinant Rat 4F2 cell-surface antigen heavy chain (Slc3a2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SLC3A2 Proteins for Oryctolagus cuniculus (Rabbit)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP800072RB CSB-BP800072RB CSB-MP800072RB CSB-EP800072RB-B |
Recombinant Rabbit 4F2 cell-surface antigen heavy chain (SLC3A2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
