CCR8
CCR8，即C-C基序趨化因子受體8，別名CD198、ChemR1、CKRL1、CKR-L1、CY6、GPRCL1、GPRCY6、GPR-CY6、TER-1等。CCR8是一種七次跨膜G蛋白偶聯(lián)受體，屬于趨化因子受體C-C亞家族。CCR8的作用機(jī)制涉及與其配體CCL1、CCL8、CCL16和CCL18的結(jié)合，其中CCL1是其主要配體。這些相互作用參與了多種腫瘤的發(fā)展進(jìn)程及介導(dǎo)腫瘤的免疫逃逸。CCR8主要在腫瘤微環(huán)境中的調(diào)節(jié)性T細(xì)胞（Treg）上特異性高表達(dá)，而在周?chē)＝M織和外周血中低表達(dá)，因此CCR8可以作為T(mén)reg細(xì)胞的一種特異性標(biāo)志物，是一種有潛力的治療靶點(diǎn)和生物標(biāo)志物。CCR8的高表達(dá)與多種癌癥相關(guān)，包括結(jié)直腸癌、乳腺癌、胃癌等，被認(rèn)為是腫瘤部位Treg的潛在特異性標(biāo)記物，是極具潛力的腫瘤免疫靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human C-C chemokine receptor type 8 (CCR8) (CSB-CF004847HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCR8 Recombinant Monoclonal Antibody (CSB-RA004847A1HU)
驗(yàn)證數(shù)據(jù)
Untransfected HEK293T cells surface (green line) and transfected Human CCR8 HEK293T stable cells surface (red line) were stained with anti-CCR8 antibody (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
CCR8 Recombinant Monoclonal Antibody (CSB-RA004847MA3HU)
驗(yàn)證數(shù)據(jù)
Untransfected CHO-K1 cells surface(green line) and transfected Human CCR8 CHO-K1 stable cells surface (red line) were stained with anti-CCR8 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
The Binding Activity of CCR8 with Anti-CCR8 recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CCR8 (CSB-MP004847HU) at 5 μg/mL can bind Anti-CCR8 recombinant antibody, the EC50 is 11.20-15.63 ng/mL.
CCR8 Antibodies
CCR8 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA091770 | CCR8 Antibody | Human | ELISA,WB,IHC |
| CSB-PA172806 | CCR8 Antibody | Human | ELISA,WB,IHC |
| CSB-RA004847A1HU | CCR8 Recombinant Monoclonal Antibody | Human | FC |
| CSB-RA004847MA2HU | CCR8 Recombinant Monoclonal Antibody | Human | FC |
| CSB-RA004847MA3HU | CCR8 Recombinant Monoclonal Antibody | Human | ELISA, FC |
| CSB-RA004847MA4HU | CCR8 Recombinant Monoclonal Antibody | Human | FC |
CCR8 Proteins
CCR8 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-EP004847HU1 CSB-BP004847HU1 CSB-MP004847HU1 CSB-EP004847HU1-B |
Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004847HU | Recombinant Human C-C chemokine receptor type 8 (CCR8) | in vitro E.coli expression system |
| CSB-CF004847HU2 | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | in vitro E.coli expression system |
| CSB-CF004847HU2-N | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial,Nanodiscs | in vitro E.coli expression system |
| CSB-YP004847HU1 | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | Yeast |
| CSB-MP004847HU | Recombinant Human C-C chemokine receptor type 8 (CCR8)-VLPs (Active) | Mammalian cell |
CCR8 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP004847MO1 CSB-EP004847MO1 CSB-BP004847MO1 CSB-MP004847MO1 CSB-EP004847MO1-B |
Recombinant Mouse C-C chemokine receptor type 8 (Ccr8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004847MO | Recombinant Mouse C-C chemokine receptor type 8 (Ccr8) | in vitro E.coli expression system |
| CSB-MP004847MO | Recombinant Mouse C-C chemokine receptor type 8 (Ccr8)-VLPs | Mammalian cell |
CCR8 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP004847MOW1 CSB-EP004847MOW1 CSB-BP004847MOW1 CSB-MP004847MOW1 CSB-EP004847MOW1-B |
Recombinant Macaca mulatta C-C chemokine receptor type 8 (CCR8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004847MOW | Recombinant Macaca mulatta C-C chemokine receptor type 8 (CCR8) | in vitro E.coli expression system |
