FTH1

FTH1，即鐵蛋白重鏈1，別名FHC、FTH、FTHL6、HFE5、PIG15、PLIF等。它廣泛來源于動物和植物細胞，是鐵蛋白的主要組成部分。FTH1能夠將機體內的鐵離子催化成Fe3+并儲存，以維持正常的鐵穩態；具有亞鐵氧化酶活性，促進鐵的氧化和細胞對鐵的攝取；還具備抗氧化應激功能，能夠降解自由基，有效阻止由過量鐵引起的氧化損害。FTH1參與鐵代謝過程，包括鐵的吸收、轉運和利用，同時還參與免疫應答、細胞增殖等生理過程，并對細胞具有保護作用。FTH1還與多種疾病的發生相關，如鐵過載、神經退行性疾病等，因此調控FTH1的表達可能是多種疾病潛在的治療靶點。

熱銷產品

Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) (CSB-MP007479HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP007479HU could indicate that this peptide derived from Mammalian Cell-expressed Homo sapiens (Human) EGFR.

Measured by its binding ability in a functional ELISA. Immobilized EGFR at 1 μg/ml can bind Anti-EGFR recombinant antibody, the EC50 of human EGFR protein is 2.867-3.571 ng/ml.

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

Activity
Measured by its binding ability in a functional ELISA. Immobilized EGFR at 1 μg/ml can bind Cetuximab, the EC₅₀ of human EGFR protein is 0.6919-1.047 ng/ml.

The purity of EGFR was greater than 95% as determined by SEC-HPLC

EGFR Recombinant Monoclonal Antibody (CSB-RA159341MA1HU)

驗證數據

IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

Overlay Peak curve showing NIH/3T3 cells stained with CSB-RA159341MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Rabbit IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

FTH1 Antibody

FTH1 Protein

FTH1 ELISA Kit

FTH1 Antibodies

FTH1 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA02084A0Rb	FTH1 Antibody	Human	ELISA
CSB-PA02084B0Rb	FTH1 Antibody, HRP conjugated	Human	ELISA
CSB-PA02084C0Rb	FTH1 Antibody, FITC conjugated	Human
CSB-PA02084D0Rb	FTH1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA02089A0Rb	FTH1 Antibody	Human	ELISA
CSB-PA02089B0Rb	FTH1 Antibody, HRP conjugated	Human	ELISA
CSB-PA02089D0Rb	FTH1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA008485	FTH1 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA358768	FTH1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA247700	FTH1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-RA574579A0HU	FTH1 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB, IF, FC
CSB-RA009030MA1HU	FTH1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, FC

FTH1 Proteins

FTH1 Proteins for Sus scrofa (Pig)

產品貨號	產品名稱	來源
CSB-YP009030PI CSB-EP009030PI CSB-BP009030PI CSB-MP009030PI CSB-EP009030PI-B	Recombinant Pig Ferritin heavy chain (FTH1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FTH1 Proteins for Ovis aries (Sheep)

產品貨號	產品名稱	來源
CSB-YP009030SH CSB-EP009030SH CSB-BP009030SH CSB-MP009030SH CSB-EP009030SH-B	Recombinant Sheep Ferritin heavy chain (FTH1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FTH1 Proteins for Oryctolagus cuniculus (Rabbit)

產品貨號	產品名稱	來源
CSB-YP009030RB CSB-EP009030RB CSB-BP009030RB CSB-MP009030RB CSB-EP009030RB-B	Recombinant Rabbit Ferritin heavy chain (FTH1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FTH1 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP009030HU CSB-BP009030HU CSB-MP009030HU CSB-EP009030HU-B	Recombinant Human Ferritin heavy chain (FTH1)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP009030HU1	Recombinant Human Ferritin heavy chain (FTH1)	E.coli
CSB-EP009030HU(M)	Recombinant Human Ferritin heavy chain (FTH1) (C103A)	E.coli
CSB-EP009030HU(M1)	Recombinant Human Ferritin heavy chain (FTH1) (H106A)	E.coli
CSB-EP009030HU	Recombinant Human Ferritin heavy chain (FTH1)	E.coli

FTH1 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP009030MO CSB-BP009030MO CSB-MP009030MO CSB-EP009030MO-B	Recombinant Mouse Ferritin heavy chain (Fth1)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FTH1 Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP009030BO CSB-EP009030BO CSB-BP009030BO CSB-MP009030BO CSB-EP009030BO-B	Recombinant Bovine Ferritin heavy chain (FTH1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FTH1 Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP009030RA CSB-EP009030RA CSB-BP009030RA CSB-MP009030RA CSB-EP009030RA-B	Recombinant Rat Ferritin heavy chain (Fth1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FTH1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

產品貨號	產品名稱	來源
CSB-YP009030DXU CSB-EP009030DXU CSB-BP009030DXU CSB-MP009030DXU CSB-EP009030DXU-B	Recombinant Cricetulus griseus Ferritin heavy chain (FTH1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FTH1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

產品貨號	產品名稱	來源
CSB-YP327818SVG1 CSB-EP327818SVG1 CSB-BP327818SVG1 CSB-MP327818SVG1 CSB-EP327818SVG1-B	Recombinant Saccharomyces cerevisiae Iron transporter FTH1 (FTH1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF327818SVG	Recombinant Saccharomyces cerevisiae Iron transporter FTH1 (FTH1)	in vitro E.coli expression system

FTH1 Proteins for Felis catus (Cat) (Felis silvestris catus)

產品貨號	產品名稱	來源
CSB-YP646663CA CSB-EP646663CA CSB-BP646663CA CSB-MP646663CA CSB-EP646663CA-B	Recombinant Cat Ferritin heavy chain (FTH1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FTH1 Proteins for Pongo abelii (Sumatran orangutan)

產品貨號	產品名稱	來源
CSB-YP728971PYX CSB-EP728971PYX CSB-BP728971PYX CSB-MP728971PYX CSB-EP728971PYX-B	Recombinant Pongo abelii Ferritin heavy chain (FTH1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FTH1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產品貨號	產品名稱	來源
CSB-YP842569DO CSB-EP842569DO CSB-BP842569DO CSB-MP842569DO CSB-EP842569DO-B	Recombinant Dog Ferritin heavy chain (FTH1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FTH1 Proteins for Trichosurus vulpecula (Brush-tailed possum)

產品貨號	產品名稱	來源
CSB-YP895017TQG CSB-EP895017TQG CSB-BP895017TQG CSB-MP895017TQG CSB-EP895017TQG-B	Recombinant Trichosurus vulpecula Ferritin heavy chain (FTH1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli