F3
F3，即組織因子，別名CD142、TF、TFA。它是由263個氨基酸殘基組成的跨膜單鏈糖蛋白，分子量約為47 kDa。F3的作用機制是通過與因子VII/VIIa結(jié)合啟動血液凝固級聯(lián)反應(yīng)。它與細(xì)胞膜緊密結(jié)合，發(fā)揮“錨”作用，使生理性凝血過程局限于損傷部位。F3可以同時激活凝血因子Ⅸ和Ⅹ，啟動內(nèi)、外源性兩種凝血酶聯(lián)放大反應(yīng)，在血栓形成過程中起著重要作用。然而，在生理濃度時，F(xiàn)3和FⅦ單獨存在都不具有促凝活性。F3在腫瘤患者中常伴有血液凝固性增強，并且在腫瘤組織中也常見血栓的形成，這可能與腫瘤血管內(nèi)皮細(xì)胞和腫瘤細(xì)胞上組織因子F3的異常高表達(dá)相關(guān)。F3的高表達(dá)直接影響細(xì)胞增殖、組織浸潤性、轉(zhuǎn)移性等生物學(xué)特征，已成為腫瘤研究中頗具潛力的治療靶標(biāo)。
熱銷產(chǎn)品
Recombinant Human Tissue factor (F3), partial (Active) (CSB-MP007928HU2)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TF at 2 μg/ml can bind Anti-TF recombinant antibody (CSB-RA007928MA2HU). The EC50 is 1.434-1.635 ng/mL.
The purity of F3 was greater than 95% as determined by SEC-HPLC
Recombinant Human Serotransferrin(TF) (Active) (CSB-MP023412HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized TFRC(CSB-MP3648HU)at 2μg/mL can bind Human TF，the EC50 is 58.72-77.84 ng/mL.
Recombinant Macaca fascicularis Tissue factor (F3), partial (Active) (CSB-MP6582MOV)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis F3 at 2 μg/ml can bind Anti-F3 recombinant antibody (CSB-RA007928MA2HU). The EC50 is 0.4495-0.5538 ng/mL.
F3 Antibodies
F3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007928LA01HU | F3 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA004263 | F3 Antibody | Human,Monkey | WB, ELISA |
| CSB-PA005114 | F3 Antibody | Human | WB, ELISA |
| CSB-PA008166 | Phospho-F3 (S290) Antibody | Human | WB, IHC, ELISA |
| CSB-PA040718 | F3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA981490 | F3 Antibody | Human | ELISA,IHC |
| CSB-RA776663A0HU | F3 Recombinant Monoclonal Antibody | Human, Rat | ELISA, WB, IHC |
F3 Proteins
F3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP007928HU1 CSB-MP007928HU1 CSB-EP007928HU1-B |
Recombinant Human Tissue factor (F3), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007928HU | Recombinant Human Tissue factor (F3) | in vitro E.coli expression system |
| CSB-EP007928HU1 | Recombinant Human Tissue factor (F3), partial | E.coli |
| CSB-EP007928HU(F2) | Recombinant Human Tissue factor (F3) | E.coli |
| CSB-MP007928HU2 | Recombinant Human Tissue factor (F3), partial (Active) | Mammalian cell |
| CSB-MP007928HU-WD | Recombinant Human Tissue factor (F3), partial | Mammalian cell |
F3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007928MO1 CSB-EP007928MO1 CSB-BP007928MO1 CSB-EP007928MO1-B |
Recombinant Mouse Tissue factor (F3), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF007928MO | Recombinant Mouse Tissue factor (F3) | in vitro E.coli expression system |
F3 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007928RB1 CSB-EP007928RB1 CSB-BP007928RB1 CSB-MP007928RB1 CSB-EP007928RB1-B |
Recombinant Rabbit Tissue factor (F3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007928RB | Recombinant Rabbit Tissue factor (F3) | in vitro E.coli expression system |
F3 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007928BO1 CSB-EP007928BO1 CSB-BP007928BO1 CSB-MP007928BO1 CSB-EP007928BO1-B |
Recombinant Bovine Tissue factor (F3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007928BO | Recombinant Bovine Tissue factor (F3) | in vitro E.coli expression system |
F3 Proteins for Microplitis demolitor bracovirus (isolate Webb) (MdBV)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP686307MDAK CSB-EP686307MDAK CSB-BP686307MDAK CSB-MP686307MDAK CSB-EP686307MDAK-B |
Recombinant Microplitis demolitor bracovirus I-Kappa-B like protein F2 (F3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F3 Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP888355GU CSB-EP888355GU CSB-BP888355GU CSB-MP888355GU CSB-EP888355GU-B |
Recombinant Guinea pig Tissue factor (F3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F3 ELISA Kit
F3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07913h | Human tissue factor (TF) ELISA kit | serum, plasma, tissue homogenates | 0.78 pg/mL |
F3 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07914r | Rat Tissue factor,TF ELISA Kit | serum, urine, cell culture supernates, tissue homogenates, cell lysates | 7.8 pg/mL |
F3 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17813m | Mouse coagulation factor Ⅲ,FⅢ ELISA Kit | serum, plasma, tissue homogenates | 1.95 pg/mL |
