RXFP1
RXFP1蛋白，全稱為Relaxin family peptide receptor 1，常見別名為RXFPR1，是松弛素家族肽受體的一種。該蛋白主要表達于腎臟、脾臟、胎盤、睪丸、胰腺和腎上腺等組織中，在人類心臟心房肌細胞中的表達較低。RXFP1蛋白能夠與松弛素-2結合，激活下游信號通路，引發(fā)血管擴張、血管生成、抗炎反應以及通過膠原降解重塑細胞外基質(zhì)等多種細胞效應。因此，RXFP1蛋白被認為是心血管和纖維化疾病藥物研發(fā)的潛力靶點。目前，全球已有多個藥企針對RXFP1蛋白研發(fā)出多款藥物，如AZD3427、AZD5462、mRNA-0184、BMS-986259等，這些藥物主要被開發(fā)用于治療心力衰竭和肺動脈高壓。其中，AZD3427是一款松弛素模擬物，正在開展治療心力衰竭和肺動脈高壓的2期臨床試驗；AZD5462是一款RXFP1受體激動劑，其治療慢性心臟衰竭的2期臨床試驗正在進行中；mRNA-0184是Moderna開發(fā)的一款治療失代償性心力衰竭的mRNA療法，目前處于I期臨床。RXFP1蛋白及其相關藥物的研發(fā)，為心血管和纖維化疾病的治療提供了新的希望。
熱銷產(chǎn)品
RXFP1 Antibody (CSB-PA875715LA01HU)
驗證數(shù)據(jù)
Immunofluorescence staining of Hela cells with CSB-PA875715LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
RXFP1 Antibodies
RXFP1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA875715LA01HU | RXFP1 Antibody | Human | ELISA, IF |
| CSB-PA875715LB01HU | RXFP1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA875715LD01HU | RXFP1 Antibody, Biotin conjugated | Human | ELISA |
RXFP1 Proteins
RXFP1 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP725279PYX1 CSB-EP725279PYX1 CSB-BP725279PYX1 CSB-MP725279PYX1 CSB-EP725279PYX1-B |
Recombinant Pongo abelii Relaxin receptor 1 (RXFP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF725279PYX | Recombinant Pongo abelii Relaxin receptor 1 (RXFP1) | in vitro E.coli expression system |
RXFP1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP744175RA1 CSB-EP744175RA1 CSB-BP744175RA1 CSB-MP744175RA1 CSB-EP744175RA1-B |
Recombinant Rat Relaxin receptor 1 (Rxfp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF744175RA | Recombinant Rat Relaxin receptor 1 (Rxfp1) | in vitro E.coli expression system |
RXFP1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP764847MO1 CSB-EP764847MO1 CSB-BP764847MO1 CSB-MP764847MO1 CSB-EP764847MO1-B |
Recombinant Mouse Relaxin receptor 1 (Rxfp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF764847MO | Recombinant Mouse Relaxin receptor 1 (Rxfp1) | in vitro E.coli expression system |
RXFP1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP875715HU1 CSB-EP875715HU1 CSB-BP875715HU1 CSB-MP875715HU1 CSB-EP875715HU1-B |
Recombinant Human Relaxin receptor 1 (RXFP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF875715HU | Recombinant Human Relaxin receptor 1 (RXFP1) | in vitro E.coli expression system |
