KLRK1
NKG2D蛋白（又稱(chēng)為CD314）由KLRK1基因編碼，是一種人類(lèi)天然殺傷細(xì)胞，在天然免疫中發(fā)揮著重要的作用。NKG2D作為一種活性受體，NKG2D可以在人類(lèi)和小鼠的NK細(xì)胞、CD8+T細(xì)胞和其他免疫活性細(xì)胞中表達(dá)，但在CD4+T細(xì)胞中通常不表達(dá)。與其他NKG2受體不同，NKG2D擁有多種配體，包括人類(lèi)MHC-I類(lèi)鏈相關(guān)分子（MICA和MICB）和人類(lèi)UL16結(jié)合蛋白（ULBPs，也稱(chēng)為人類(lèi)RAET1）。NKG2D及其配體（NKG2D/NKG2DL）可以介導(dǎo)免疫細(xì)胞的腫瘤殺傷作用。NKX101是Nkarta所研發(fā)的第一個(gè)靶向NKG2D的“通用型”CAR-NK細(xì)胞療法。用于治療復(fù)發(fā)/難治性急性髓細(xì)胞白血病（AML）或高危骨髓增生異常綜合征（MDS）。目前以NKG2D為靶點(diǎn)的在研藥物/療法主要集中在臨床早期，作用機(jī)制以CAR-T/CAR-NK為主，適應(yīng)癥以血液瘤為主。除此之外CAR-NK療法不需要以患者的自體免疫細(xì)胞作為來(lái)源、治療成本更低等優(yōu)勢(shì)可能使它成為CAR-T療法的一大競(jìng)爭(zhēng)對(duì)手。
Recombinant Human KLRK1 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)
SDS-PAGE
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized KLRK1 at 10 μg/ml can bind human Biotinylated ULBP1(CSB-MP887177HUj1-B), the EC50 is 4.254-7.295 ng/ml.
Human KLRK1 protein Fc tag (CSB-MP012474HU1) captured on COOH chip can bind Human ULBP1 protein Fc/myc tag (CSB-MP887177HU) with an affinity constant of 2.27 nM as detected by LSPR Assay.
KLRK1 Antibodies
KLRK1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA008277 | KLRK1 Antibody | Human | WB, ELISA |
| CSB-PA012474LA01HU | KLRK1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA012474LB01HU | KLRK1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012474LC01HU | KLRK1 Antibody, FITC conjugated | Human | |
| CSB-PA012474LD01HU | KLRK1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA888677 | KLRK1 Antibody | Human | IHC,ELISA |
KLRK1 Proteins
KLRK1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP012474HU1 CSB-EP012474HU1 CSB-BP012474HU1 CSB-EP012474HU1-B |
Recombinant Human NKG2-D type II integral membrane protein (KLRK1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF012474HU | Recombinant Human NKG2-D type II integral membrane protein (KLRK1) | in vitro E.coli expression system |
| CSB-MP012474HU1 | Recombinant Human NKG2-D type II integral membrane protein (KLRK1), partial (Active) | Mammalian cell |
KLRK1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP012474MO1 CSB-EP012474MO1 CSB-BP012474MO1 CSB-MP012474MO1 CSB-EP012474MO1-B |
Recombinant Mouse NKG2-D type II integral membrane protein (Klrk1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012474MO | Recombinant Mouse NKG2-D type II integral membrane protein (Klrk1) | in vitro E.coli expression system |
KLRK1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP012474RA1 CSB-EP012474RA1 CSB-BP012474RA1 CSB-MP012474RA1 CSB-EP012474RA1-B |
Recombinant Rat NKG2-D type II integral membrane protein (Klrk1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012474RA | Recombinant Rat NKG2-D type II integral membrane protein (Klrk1) | in vitro E.coli expression system |
KLRK1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP012474MOV1 CSB-EP012474MOV1 CSB-BP012474MOV1 CSB-MP012474MOV1 CSB-EP012474MOV1-B |
Recombinant Macaca fascicularis NKG2-D type II integral membrane protein (KLRK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012474MOV | Recombinant Macaca fascicularis NKG2-D type II integral membrane protein (KLRK1) | in vitro E.coli expression system |
KLRK1 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP836611EXP CSB-EP836611EXP CSB-BP836611EXP CSB-MP836611EXP CSB-EP836611EXP-B |
Recombinant Pongo pygmaeus NKG2-D type II integral membrane protein (KLRK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLRK1 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP878778MOW CSB-EP878778MOW CSB-BP878778MOW CSB-MP878778MOW CSB-EP878778MOW-B |
Recombinant Macaca mulatta NKG2-D type II integral membrane protein (KLRK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLRK1 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP887907PI CSB-BP887907PI CSB-EP887907PI-B |
Recombinant Pig NKG2-D type II integral membrane protein (KLRK1), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
KLRK1 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP889008EQV CSB-EP889008EQV CSB-BP889008EQV CSB-MP889008EQV CSB-EP889008EQV-B |
Recombinant Pan troglodytes NKG2-D type II integral membrane protein (KLRK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
