CCR4

C-C趨化因子受體（C-C chemokine receptor type 4，CCR4），也稱為CD194，由包含7次跨膜結構域的多肽鏈組成，屬于G蛋白偶聯受體家族。其含360個氨基酸，分子量約為41kD，主要表達于各種淋巴細胞和組織，其配體包括多種趨化因子。作為重要的趨化因子受體，CCR4與其它趨化因子配體產生結合，行使其功能，參與調控人類自身免疫疾病過程，主要包括特應性皮炎、哮喘、皮膚T細胞淋巴瘤。過去，研究人員對趨化因子的認識限于在炎癥反應中的趨化作用，然而越來越多的研究顯示，趨化因子結合其受體在腫瘤細胞的浸潤性生長，遠處轉移等行為中發揮重要作用。CCR4作為腫瘤轉移中關鍵的趨化因子受體，多項研究已證實，CCR4高表達與血液系統腫瘤以及惡性實體瘤的浸潤和預后密切相關，靶向CCR4有望成為惡性腫瘤免疫治療的新策略。

CUSABIO-哺乳包膜VLPs平臺成功開發CCR4全長膜蛋白（7次跨膜），展示了完整生物活性。

熱銷產品

Recombinant Human C-C chemokine receptor type 4 (CCR4)-VLPs (Active) (CSB-MP004843HU)

驗證數據

CSB-MP004843HU is detected by Mouse anti-6*His monoclonal antibody.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CCR4 at 10 μg/ml can bind Anti-CCR4 recombinant antibody(CSB-RA004843MA01HU), the EC₅₀ is 362.3-630.8 ng/mL.

The presence of VLP-like structures was confirmed by TEM

Recombinant Human C-C chemokine receptor type 4 (CCR4) (Active) (CSB-CF004843HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CCR4 at 5 μg/ml can bind Anti-CCR4 recombinant antibody (CSB-RA004843MA01HU). The EC₅₀ is 2.803-3.369 ng/mL.

Activity
Human CCR4 Full Length Protein captured on CM5 chip can bind Human CCR4 Monoclonal Antibody (CSB-RA004843MA01HU) with an affinity constant of 3.16 nM as detected by SPR Assay(Biacore T200).

Activity
Human CCR4 Monoclonal Antibody (CSB-RA004843MA01HU) captured on Protein A Chip can bind Human CCR4 Full Length Protein with an affinity constant of 1.71 nM as detected by MetaSPR Assay (in presence of FOS-12)(WeSPR^TM 200) .

CCR4 Antibody

CCR4 Protein

CCR4 Antibodies

CCR4 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA005336	CCR4 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA006992	CCR4 Antibody	Human,Mouse,Rat	IF, ELISA
CSB-PA004843LA01HU	CCR4 Antibody	Human	ELISA, IHC, IF
CSB-RA004843MA01HU	CCR4 Recombinant Monoclonal Antibody	Human	ELISA, FC

CCR4 Proteins

CCR4 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP004843HU1 CSB-BP004843HU1 CSB-MP004843HU1 CSB-EP004843HU1-B	Recombinant Human C-C chemokine receptor type 4 (CCR4), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004843HU	Recombinant Human C-C chemokine receptor type 4 (CCR4) (Active)	in vitro E.coli expression system
CSB-EP004843HU1	Recombinant Human C-C chemokine receptor type 4 (CCR4), partial	E.coli
CSB-MP004843HU	Recombinant Human C-C chemokine receptor type 4 (CCR4)-VLPs (Active)	Mammalian cell

CCR4 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP004843MO1 CSB-EP004843MO1 CSB-BP004843MO1 CSB-MP004843MO1 CSB-EP004843MO1-B	Recombinant Mouse C-C chemokine receptor type 4 (Ccr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004843MO	Recombinant Mouse C-C chemokine receptor type 4 (Ccr4)	in vitro E.coli expression system

CCR4 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)

產品貨號	產品名稱	來源
CSB-YP373023AVC CSB-EP373023AVC CSB-BP373023AVC CSB-MP373023AVC CSB-EP373023AVC-B	Recombinant Aspergillus clavatus Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)

產品貨號	產品名稱	來源
CSB-YP373090NEZ CSB-EP373090NEZ CSB-BP373090NEZ CSB-MP373090NEZ CSB-EP373090NEZ-B	Recombinant Neosartorya fischeri Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Aspergillus niger (strain CBS 513.88 / FGSC A1513)

產品貨號	產品名稱	來源
CSB-YP382681AVE CSB-EP382681AVE CSB-BP382681AVE CSB-MP382681AVE CSB-EP382681AVE-B	Recombinant Aspergillus niger Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)

產品貨號	產品名稱	來源
CSB-YP488323EMA CSB-EP488323EMA CSB-BP488323EMA CSB-MP488323EMA CSB-EP488323EMA-B	Recombinant Enterocytozoon bieneusi Probable glucose-repressible alcohol dehydrogenase transcriptional effector homolog (CCR4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Nosema ceranae (strain BRL01) (Microsporidian parasite)

產品貨號	產品名稱	來源
CSB-YP505300NHO CSB-EP505300NHO CSB-BP505300NHO CSB-MP505300NHO CSB-EP505300NHO-B	Recombinant Nosema ceranae Probable glucose-repressible alcohol dehydrogenase transcriptional effector homolog (CCR4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

產品貨號	產品名稱	來源
CSB-YP527967SXV CSB-EP527967SXV CSB-BP527967SXV CSB-MP527967SXV CSB-EP527967SXV-B	Recombinant Schizosaccharomyces pombe Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Aspergillus terreus (strain NIH 2624 / FGSC A1156)

產品貨號	產品名稱	來源
CSB-YP607711APT CSB-EP607711APT CSB-BP607711APT CSB-MP607711APT CSB-EP607711APT-B	Recombinant Aspergillus terreus Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)

產品貨號	產品名稱	來源
CSB-YP609913EUG CSB-EP609913EUG CSB-BP609913EUG CSB-MP609913EUG CSB-EP609913EUG-B	Recombinant Phaeosphaeria nodorum Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Coccidioides immitis (strain RS) (Valley fever fungus)

產品貨號	產品名稱	來源
CSB-YP625614DUV CSB-EP625614DUV CSB-BP625614DUV CSB-MP625614DUV CSB-EP625614DUV-B	Recombinant Coccidioides immitis Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

產品貨號	產品名稱	來源
CSB-YP652755DPA CSB-EP652755DPA CSB-BP652755DPA CSB-MP652755DPA CSB-EP652755DPA-B	Recombinant Aspergillus oryzae Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

產品貨號	產品名稱	來源
CSB-YP681250NGS CSB-EP681250NGS CSB-BP681250NGS CSB-MP681250NGS CSB-EP681250NGS-B	Recombinant Neosartorya fumigata Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

產品貨號	產品名稱	來源
CSB-YP685477CZD CSB-EP685477CZD CSB-BP685477CZD CSB-MP685477CZD CSB-EP685477CZD-B	Recombinant Candida albicans Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

產品貨號	產品名稱	來源
CSB-YP685553EKF CSB-EP685553EKF CSB-BP685553EKF CSB-MP685553EKF CSB-EP685553EKF-B	Recombinant Emericella nidulans Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Ustilago maydis (strain 521 / FGSC 9021) (Smut fungus)

產品貨號	產品名稱	來源
CSB-YP700033UBS CSB-EP700033UBS CSB-BP700033UBS CSB-MP700033UBS CSB-EP700033UBS-B	Recombinant Ustilago maydis Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)

產品貨號	產品名稱	來源
CSB-YP731895DIS CSB-EP731895DIS CSB-BP731895DIS CSB-MP731895DIS CSB-EP731895DIS-B	Recombinant Debaryomyces hansenii Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

產品貨號	產品名稱	來源
CSB-YP731995YAP CSB-EP731995YAP CSB-BP731995YAP CSB-MP731995YAP CSB-EP731995YAP-B	Recombinant Yarrowia lipolytica Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

產品貨號	產品名稱	來源
CSB-YP732018KBK CSB-EP732018KBK CSB-BP732018KBK CSB-MP732018KBK CSB-EP732018KBK-B	Recombinant Kluyveromyces lactis Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)

產品貨號	產品名稱	來源
CSB-YP739340CZI CSB-EP739340CZI CSB-BP739340CZI CSB-MP739340CZI CSB-EP739340CZI-B	Recombinant Candida glabrata Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

產品貨號	產品名稱	來源
CSB-YP751781DOT CSB-EP751781DOT CSB-BP751781DOT CSB-MP751781DOT CSB-EP751781DOT-B	Recombinant Ashbya gossypii Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)

產品貨號	產品名稱	來源
CSB-YP823404EKH CSB-EP823404EKH CSB-BP823404EKH CSB-MP823404EKH CSB-EP823404EKH-B	Recombinant Encephalitozoon cuniculi Probable glucose-repressible alcohol dehydrogenase transcriptional effector homolog (CCR4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產品貨號	產品名稱	來源
CSB-YP839750DO1 CSB-EP839750DO1 CSB-BP839750DO1 CSB-MP839750DO1 CSB-EP839750DO1-B	Recombinant Dog C-C chemokine receptor type 4 (CCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF839750DO	Recombinant Dog C-C chemokine receptor type 4 (CCR4)	in vitro E.coli expression system

CCR4 Proteins for Arabidopsis thaliana (Mouse-ear cress)

產品貨號	產品名稱	來源
CSB-YP866940DOA CSB-EP866940DOA CSB-BP866940DOA CSB-MP866940DOA CSB-EP866940DOA-B	Recombinant Arabidopsis thaliana Serine/threonine-protein kinase-like protein CCR4 (CCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR4 Proteins for Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

產品貨號	產品名稱	來源
CSB-YP880175NHA CSB-EP880175NHA CSB-BP880175NHA CSB-MP880175NHA CSB-EP880175NHA-B	Recombinant Neurospora crassa Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr-4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli